Lista de obras -

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation

artículo científico publicado en 2012

A new crystal form of human vascular adhesion protein 1

artículo científico publicado en 2010

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

artículo científico publicado en 2009

APOMAB® antibody drug conjugates targeting dead tumor cells are effective in vivo

artículo científico publicado en 2018

Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response

artículo científico publicado en 2018

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

artículo científico publicado en 2009

Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.

artículo científico publicado en 2012

Blood-based protein biomarker panel for the detection of colorectal cancer

artículo científico publicado en 2015

C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response

artículo científico publicado en 2018

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

scientific article published on 11 July 2018

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation

artículo científico publicado en 2017

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

artículo científico publicado en 2004

Cloning and DNA sequence analysis of the cDNA for the common alpha-subunit of the ovine pituitary glycoprotein hormones

artículo científico publicado en 1989

Colorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelled

artículo científico publicado en 2014

Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

artículo científico publicado en 2014

Comparison of intrahepatic lymphocytes from normal and growth hormone transgenic mice with chronic hepatitis and liver cancer.

artículo científico publicado en 1997

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

artículo científico publicado en 2009

Development of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes.

artículo científico publicado en 2017

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

artículo científico publicado en 2018

Direct involvement of the TEN domain at the active site of human telomerase

artículo científico publicado en 2010

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation

scientific article published on 03 October 2019

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.

artículo científico publicado en 2015

Electrostatic interactions between Hendra virus matrix proteins are required for efficient virus-like particle assembly.

artículo científico publicado en 2018

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation

artículo científico publicado en 2011

Functional expression of an ovine growth hormone receptor in transfected Chinese hamster ovary cells

artículo científico publicado el 1 de julio de 1992

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

artículo científico publicado en 2011

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo

artículo científico publicado en 2014

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

artículo científico publicado en 2002

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice

scientific article published on 01 June 1999

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.

artículo científico publicado en 2001

Identification of a liver-specific promoter for the ovine growth hormone receptor.

artículo científico publicado en 1994

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

artículo científico publicado en 2004

Incomplete target neutralization by the anti-cancer antibody rilotumumab

artículo científico publicado en 2016

Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity

artículo científico publicado en 2018

Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses

scientific article published on 05 March 2019

LRIG1 extracellular domain: structure and function analysis

artículo científico publicado en 2015

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation.

artículo científico publicado en 2013

Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MToGH1) in transgenic mice

artículo científico publicado en 1995

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

artículo científico publicado en 2016

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

scientific article published in Nature

Notch ligand delta-like1: X-ray crystal structure and binding affinity

artículo científico publicado en 2015

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

artículo científico publicado en 2001

Positive and negative regulatory elements in the late lactation protein-A gene promoter from the tammar wallaby (Macropus eugenii).

artículo científico publicado en 2005

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

artículo científico publicado en 2012

Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase

scientific article published on 01 June 2002

Production of methionyl-minus ovine growth hormone in Escherichia coli and one-step purification

artículo científico publicado en 1992

Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region

scientific article published on 01 March 2000

Removal of 3'untranslated sequences dramatically enhances transient expression of ovine follicle-stimulating hormone Beta gene messenger ribonucleic Acid

artículo científico publicado en 1992

STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver

artículo científico publicado en 1999

Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor

artículo científico publicado en 2004

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

artículo científico publicado en 2009

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

artículo científico publicado en 2015

Structural and functional characterisation of ferret interleukin-2

artículo científico publicado en 2016

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

artículo científico publicado en 2018

Structural insights into ligand-induced activation of the insulin receptor.

artículo científico publicado en 2008

Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

artículo científico publicado en 2013

Structure and function of the type 1 insulin-like growth factor receptor.

artículo científico publicado en 2000

Taking down the FLAG! How insect cell expression challenges an established tag-system

artículo científico publicado en 2012

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

artículo científico publicado en 2003

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

artículo científico publicado en 2007

The sheep growth hormone receptor: molecular cloning and ontogeny of mRNA expression in the liver.

artículo científico publicado en 1990

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

artículo científico publicado en 2014

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

artículo científico publicado en 2009

UV induced responses of the human epidermal IGF system: impaired anti-apoptotic effects of IGF-I in HaCaT keratinocytes.

artículo científico publicado en 2005

Lista de obras de

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation

A new crystal form of human vascular adhesion protein 1

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

APOMAB® antibody drug conjugates targeting dead tumor cells are effective in vivo

Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.

Blood-based protein biomarker panel for the detection of colorectal cancer

C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

Cloning and DNA sequence analysis of the cDNA for the common alpha-subunit of the ovine pituitary glycoprotein hormones

Colorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelled

Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

Comparison of intrahepatic lymphocytes from normal and growth hormone transgenic mice with chronic hepatitis and liver cancer.

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

Development of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes.

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Direct involvement of the TEN domain at the active site of human telomerase

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.

Electrostatic interactions between Hendra virus matrix proteins are required for efficient virus-like particle assembly.

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation

Functional expression of an ovine growth hormone receptor in transfected Chinese hamster ovary cells

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.

Identification of a liver-specific promoter for the ovine growth hormone receptor.

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

Incomplete target neutralization by the anti-cancer antibody rilotumumab

Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity

Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses

LRIG1 extracellular domain: structure and function analysis

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation.

Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MToGH1) in transgenic mice

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

Notch ligand delta-like1: X-ray crystal structure and binding affinity

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

Positive and negative regulatory elements in the late lactation protein-A gene promoter from the tammar wallaby (Macropus eugenii).

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase

Production of methionyl-minus ovine growth hormone in Escherichia coli and one-step purification

Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region

Removal of 3'untranslated sequences dramatically enhances transient expression of ovine follicle-stimulating hormone Beta gene messenger ribonucleic Acid

STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver

Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

Structural and functional characterisation of ferret interleukin-2

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

Structural insights into ligand-induced activation of the insulin receptor.

Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

Structure and function of the type 1 insulin-like growth factor receptor.

Taking down the FLAG! How insect cell expression challenges an established tag-system

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

The sheep growth hormone receptor: molecular cloning and ontogeny of mRNA expression in the liver.

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

UV induced responses of the human epidermal IGF system: impaired anti-apoptotic effects of IGF-I in HaCaT keratinocytes.