Lista de obras - Francesco Antonio Aprile

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate

artículo científico publicado en 2015

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

artículo científico publicado en 2018

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

artículo científico publicado en 2017

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

artículo científico publicado en 2017

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

artículo científico publicado en 2018

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates

artículo científico

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

artículo científico publicado en 2019

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

artículo científico publicado en 2015

Cooperative Assembly of Hsp70 Subdomain Clusters

scientific article published on 29 May 2018

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

artículo científico publicado en 2017

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Direct observation of the interconversion of normal and toxic forms of α-synuclein

artículo científico publicado en 2012

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

scientific article published on 19 July 2019

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

artículo científico publicado en 2013

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

scientific article published on March 2017

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

artículo científico publicado en 2017

Methods of probing the interactions between small molecules and disordered proteins

artículo científico

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

artículo científico publicado en 2015

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

artículo científico publicado en 2016

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

artículo científico publicado en 2014

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Publisher Correction: The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.

artículo científico publicado en 2018

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

artículo científico publicado en 2020

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

artículo científico publicado en 2015

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

artículo científico publicado en 2020

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

artículo científico publicado en 2017

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

artículo científico publicado en 2017

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

artículo científico publicado en 2020

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

artículo científico publicado en 2019

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

artículo científico publicado en 2015

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

artículo científico publicado en 2015

Structure of a low-population binding intermediate in protein-RNA recognition

artículo científico publicado en 2016

Structure of a low-population intermediate state in the release of an enzyme product

artículo científico publicado en 2015

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms

scholarly article by Sofia Giorgetti published in September 2018

The CamSol method of rational design of protein mutants with enhanced solubility

artículo científico publicado en 2014

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

artículo científico publicado en 2021

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

artículo científico publicado en 2017

The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris

artículo científico publicado en 2017

The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli

artículo científico publicado en 2012

Third generation antibody discovery methods: in silico rational design

scientific article published on 01 December 2018

Lista de obras de Francesco Antonio Aprile

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

Cooperative Assembly of Hsp70 Subdomain Clusters

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Direct observation of the interconversion of normal and toxic forms of α-synuclein

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

Methods of probing the interactions between small molecules and disordered proteins

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

Publisher Correction: The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

Structure of a low-population binding intermediate in protein-RNA recognition

Structure of a low-population intermediate state in the release of an enzyme product

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms

The CamSol method of rational design of protein mutants with enhanced solubility

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris

The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli

Third generation antibody discovery methods: in silico rational design