Lista de obras -

A functional antibody lacking N-linked glycans is efficiently folded, assembled and secreted by tobacco mesophyll protoplasts.

artículo científico publicado en 2005

A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity.

artículo científico publicado en 2018

A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells

article published in 2004

A synthetic peptide adhesion epitope as a novel antimicrobial agent.

artículo científico publicado en 1999

Alga-Made Anti-Hepatitis B Antibody Binds to Human Fcγ Receptors.

artículo científico publicado en 2017

Antibody degradation in tobacco plants: a predominantly apoplastic process

artículo científico publicado en 2011

Antibody processing and engineering in plants, and new strategies for vaccine production.

artículo científico publicado en 2005

Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants

scientific article published on 01 January 1994

Breakage of transgenic tobacco roots for monoclonal antibody release in an ultra‐scale down shearing device ⬇️

artículo científico publicado el 20 de septiembre de 2013

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco

artículo científico publicado en 2013

Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV

artículo científico publicado en 2014

Characterization of mechanical properties of transgenic tobacco roots expressing a recombinant monoclonal antibody against tooth decay.

artículo científico publicado en 2008

Clinical Safety and Immunogenicity of Tumor-Targeted, Plant-Made Id-KLH Conjugate Vaccines for Follicular Lymphoma.

artículo científico publicado en 2015

Combinatorial de novo design and application of a biomimetic affinity ligand for the purification of human anti-HIV mAb 4E10 from transgenic tobacco.

artículo científico publicado en 2009

Commercialization of new biotechnology: a systematic review of 16 commercial case studies in a novel manufacturing sector

artículo científico

Considerations for extraction of monoclonal antibodies targeted to different subcellular compartments in transgenic tobacco plants.

artículo científico publicado en 2008

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

artículo científico publicado en 2008

Cytokine interactions that determine the outcome of Mycobacterial infection of macrophages.

artículo científico publicado en 2010

Design, expression, and characterization of a multivalent, combination HIV microbicide.

artículo científico publicado en 2009

Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco.

artículo científico publicado en 2009

Dynamics of global disclosure through patent and journal publications for biopharmaceutical products

artículo científico publicado en 2009

Engineering the interactions between a plant-produced HIV antibody and human Fc receptors

artículo científico publicado en 2019

Engineering, expression in transgenic plants and characterisation of E559, a rabies virus-neutralising monoclonal antibody.

artículo científico publicado en 2014

Enhanced transport of plant-produced rabies single-chain antibody-RVG peptide fusion protein across an in cellulo blood-brain barrier device.

artículo científico publicado en 2017

Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants.

artículo científico publicado en 2008

Exploring the vaccine potential of Dec-205 targeting in Mycobacterium tuberculosis infection in mice ⬇️

artículo científico publicado el 25 de enero de 2011

Expression and plasma membrane localization of the mammalian B-cell receptor complex in transgenic Nicotiana tabacum.

artículo científico publicado en 2010

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana.

artículo científico publicado en 2011

Functional characterization of the recombinant HIV-neutralizing monoclonal antibody 2F5 produced in maize seeds

article

Gene expression analysis, subcellular localization, and in planta antimicrobial activity of rice (Oryza sativa L.) defensin 7 and 8.

artículo científico publicado en 2018

Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin-LR

scientific article published on 19 October 2009

Generation of transgenic plants expressing plasma membrane-bound antibodies to the environmental pollutant microcystin-LR.

artículo científico publicado en 2010

Genetically modified plants and human health

artículo científico publicado en 2008

HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production.

artículo científico publicado en 2006

High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves

article

High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.

artículo científico publicado en 2015

Highly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants.

artículo científico publicado en 2005

Identification of peptidases in Nicotiana tabacum leaf intercellular fluid

artículo científico publicado en 2008

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery ⬇️

artículo científico publicado el 23 de abril de 2013

Immunogenicity of chloroplast‐derived HIV‐1 p24 and a p24‐Nef fusion protein following subcutaneous and oral administration in mice ⬇️

artículo científico publicado el 28 de marzo de 2011

In situ delivery of passive immunity by lactobacilli producing single-chain antibodies

scientific article published on 01 July 2002

In vitro and in vivo evaluation of a single chain antibody fragment generated in planta with potent rabies neutralisation activity.

artículo científico publicado en 2018

Molecular engineering and plant expression of an immunoglobulin heavy chain scaffold for delivery of a dengue vaccine candidate

artículo científico publicado en 2017

Monoclonal antibodies for prophylactic and therapeutic use against viral infections.

artículo científico

Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice

artículo científico publicado en 2014

New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants

scientific article published on 04 October 2008

Passive immunity in the prevention of rabies.

artículo científico

Phase system selection with fractional factorial design for purification of recombinant cyanovirin-N from a hydroponic culture medium using centrifugal partition chromatography

artículo científico publicado en 2013

Plant molecular pharming for the treatment of chronic and infectious diseases

artículo científico

Plant-derived pharmaceuticals--the road forward

artículo científico publicado en 2005

Plant-derived recombinant immune complexes as self-adjuvanting TB immunogens for mucosal boosting of BCG.

artículo científico publicado en 2014

Plant-expressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties.

artículo científico publicado en 2017

Plant-made immunogens and effective delivery strategies ⬇️

artículo científico publicado el 1 de agosto de 2010

Plant-made pharmaceuticals: leading products and production platforms.

artículo científico publicado en 2011

Production of different glycosylation variants of the tumour-targeting mAb H10 in Nicotiana benthamiana: influence on expression yield and antibody degradation

artículo científico publicado en 2012

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans.

artículo científico publicado en 2013

Realising the value of plant molecular pharming to benefit the poor in developing countries and emerging economies.

artículo científico publicado en 2013

Recombinant biologic products versus nutraceuticals from plants - a regulatory choice?

artículo científico publicado en 2016

Recombinant human osteopontin expressed in Nicotiana benthamiana stimulates osteogenesis related genes in human periodontal ligament cells

artículo científico publicado en 2017

Recombinant monoclonal antibody yield in transgenic tobacco plants is affected by the wounding response via an ethylene dependent mechanism.

artículo científico publicado en 2012

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.

artículo científico publicado en 2015

Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing

artículo científico publicado en 2016

Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12.

artículo científico publicado en 2015

Site-specific proteolytic degradation of IgG monoclonal antibodies expressed in tobacco plants.

artículo científico publicado en 2014

Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants

artículo científico publicado en 2015

Sowing the seeds of success: pharmaceutical proteins from plants.

artículo científico publicado en 2005

Synthetic gene design-The rationale for codon optimization and implications for molecular pharming in plants.

artículo científico publicado en 2016

The C-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole

artículo científico publicado en 2003

The production of recombinant pharmaceutical proteins in plants.

artículo científico publicado en 2003

Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N ⬇️

artículo científico publicado el 13 de julio de 2013

Transgenic plant production of Cyanovirin-N, an HIV microbicide.

artículo científico publicado en 2005

Transgenic plants expressing antibodies: a model for phytoremediation.

artículo científico publicado en 2002

Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS

scientific article published on 25 June 2019

Lista de obras de

A functional antibody lacking N-linked glycans is efficiently folded, assembled and secreted by tobacco mesophyll protoplasts.

A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity.

A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells

A synthetic peptide adhesion epitope as a novel antimicrobial agent.

Alga-Made Anti-Hepatitis B Antibody Binds to Human Fcγ Receptors.

Antibody degradation in tobacco plants: a predominantly apoplastic process

Antibody processing and engineering in plants, and new strategies for vaccine production.

Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants

Breakage of transgenic tobacco roots for monoclonal antibody release in an ultra‐scale down shearing device ⬇️

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco

Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV

Characterization of mechanical properties of transgenic tobacco roots expressing a recombinant monoclonal antibody against tooth decay.

Clinical Safety and Immunogenicity of Tumor-Targeted, Plant-Made Id-KLH Conjugate Vaccines for Follicular Lymphoma.

Combinatorial de novo design and application of a biomimetic affinity ligand for the purification of human anti-HIV mAb 4E10 from transgenic tobacco.

Commercialization of new biotechnology: a systematic review of 16 commercial case studies in a novel manufacturing sector

Considerations for extraction of monoclonal antibodies targeted to different subcellular compartments in transgenic tobacco plants.

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

Cytokine interactions that determine the outcome of Mycobacterial infection of macrophages.

Design, expression, and characterization of a multivalent, combination HIV microbicide.

Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco.

Dynamics of global disclosure through patent and journal publications for biopharmaceutical products

Engineering the interactions between a plant-produced HIV antibody and human Fc receptors

Engineering, expression in transgenic plants and characterisation of E559, a rabies virus-neutralising monoclonal antibody.

Enhanced transport of plant-produced rabies single-chain antibody-RVG peptide fusion protein across an in cellulo blood-brain barrier device.

Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants.

Exploring the vaccine potential of Dec-205 targeting in Mycobacterium tuberculosis infection in mice ⬇️

Expression and plasma membrane localization of the mammalian B-cell receptor complex in transgenic Nicotiana tabacum.

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana.

Functional characterization of the recombinant HIV-neutralizing monoclonal antibody 2F5 produced in maize seeds

Gene expression analysis, subcellular localization, and in planta antimicrobial activity of rice (Oryza sativa L.) defensin 7 and 8.

Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin-LR

Generation of transgenic plants expressing plasma membrane-bound antibodies to the environmental pollutant microcystin-LR.

Genetically modified plants and human health

HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production.

High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves

High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.

Highly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants.

Identification of peptidases in Nicotiana tabacum leaf intercellular fluid

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery ⬇️

Immunogenicity of chloroplast‐derived HIV‐1 p24 and a p24‐Nef fusion protein following subcutaneous and oral administration in mice ⬇️

In situ delivery of passive immunity by lactobacilli producing single-chain antibodies

In vitro and in vivo evaluation of a single chain antibody fragment generated in planta with potent rabies neutralisation activity.

Molecular engineering and plant expression of an immunoglobulin heavy chain scaffold for delivery of a dengue vaccine candidate

Monoclonal antibodies for prophylactic and therapeutic use against viral infections.

Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice

New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants

Passive immunity in the prevention of rabies.

Phase system selection with fractional factorial design for purification of recombinant cyanovirin-N from a hydroponic culture medium using centrifugal partition chromatography

Plant molecular pharming for the treatment of chronic and infectious diseases

Plant-derived pharmaceuticals--the road forward

Plant-derived recombinant immune complexes as self-adjuvanting TB immunogens for mucosal boosting of BCG.

Plant-expressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties.

Plant-made immunogens and effective delivery strategies ⬇️

Plant-made pharmaceuticals: leading products and production platforms.

Production of different glycosylation variants of the tumour-targeting mAb H10 in Nicotiana benthamiana: influence on expression yield and antibody degradation

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans.

Realising the value of plant molecular pharming to benefit the poor in developing countries and emerging economies.

Recombinant biologic products versus nutraceuticals from plants - a regulatory choice?

Recombinant human osteopontin expressed in Nicotiana benthamiana stimulates osteogenesis related genes in human periodontal ligament cells

Recombinant monoclonal antibody yield in transgenic tobacco plants is affected by the wounding response via an ethylene dependent mechanism.

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.

Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing

Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12.

Site-specific proteolytic degradation of IgG monoclonal antibodies expressed in tobacco plants.

Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants

Sowing the seeds of success: pharmaceutical proteins from plants.

Synthetic gene design-The rationale for codon optimization and implications for molecular pharming in plants.

The C-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole

The production of recombinant pharmaceutical proteins in plants.

Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N ⬇️

Transgenic plant production of Cyanovirin-N, an HIV microbicide.

Transgenic plants expressing antibodies: a model for phytoremediation.

Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS