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Lista de obras de Frank Reimann

A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium

artículo científico publicado en 2015

A cross-platform approach identifies genetic regulators of human metabolism and health

scientific article published on 07 January 2021

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

artículo científico publicado en 2003

A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line

artículo científico publicado en 2003

A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells

artículo científico publicado en 2004

A tag to track short chain fatty acid sensors

artículo científico publicado en 2013

A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1

scientific article published on 29 October 2019

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

artículo científico publicado en 2010

Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets

artículo científico publicado en 2021

Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system

artículo científico publicado en 2015

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

scientific article published on 04 March 2019

An SCN9A channelopathy causes congenital inability to experience pain

artículo científico publicado en 2006

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides

artículo científico publicado en 2003

Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans

artículo científico publicado en 2016

Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome

scientific article published on 01 October 2018

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

scientific article published on 09 October 2020

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells

artículo científico publicado en 2014

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors

artículo científico publicado en 2015

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

artículo científico publicado en 2018

Butyrate Produced by Commensal Bacteria Down-Regulates () Expression a Dual Mechanism in Human Intestinal Epithelial Cells

artículo científico publicado en 2018

CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs

artículo científico publicado en 2011

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4.

artículo científico publicado en 2008

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population

artículo científico publicado en 2003

Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion

scientific article published on 30 October 2019

Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line.

artículo científico publicado en 2004

Chylomicrons stimulate incretin secretion in mouse and human cells

artículo científico publicado en 2017

Clocking up GLP-1: considering intestinal rhythms in the incretin effect

artículo científico publicado en 2014

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells.

artículo científico publicado en 2013

Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.

artículo científico publicado en 2018

Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations

artículo científico publicado en 2010

Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line

artículo científico publicado en 2007

Development and characterisation of a novel glucagon like peptide-1 receptor antibody

artículo científico publicado en 2017

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans

artículo científico publicado en 2019

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

artículo científico publicado en 2014

Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions

artículo científico publicado en 2003

Dissociation between sensing and metabolism of glucose in sugar sensing neurones.

artículo científico publicado en 2008

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

artículo científico publicado en 2015

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.

artículo científico publicado en 2000

Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults

artículo científico publicado en 2015

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel

artículo científico publicado en 2001

Electrical activity-triggered glucagon-like peptide-1 secretion from primary murine L-cells

artículo científico publicado en 2011

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

artículo científico

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

scientific article published on 23 July 2018

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.

artículo científico publicado en 2017

Erratum: Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception

artículo científico publicado en 2015

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

artículo científico publicado en 2015

Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans.

artículo científico publicado en 2014

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

artículo científico publicado en 2019

Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.

artículo científico publicado en 2016

G protein-coupled receptors as new therapeutic targets for type 2 diabetes

artículo científico

G-protein-coupled receptors in intestinal chemosensation

artículo científico publicado en 2012

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

artículo científico publicado en 2010

GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence

artículo científico publicado en 2014

GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness

artículo científico publicado en 2015

Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells

artículo científico publicado en 2015

Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery

artículo científico publicado en 2018

Generation of L cells in mouse and human small intestine organoids

artículo científico publicado en 2013

Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight.

artículo científico publicado en 2017

Glucose sensing in L cells: a primary cell study

artículo científico publicado en 2008

Glucose-sensing in glucagon-like peptide-1-secreting cells

artículo científico publicado en 2002

Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.

artículo científico publicado en 2004

Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP.

artículo científico publicado en 2011

Gut Hormone Regulation and Secretion via FFA1 and FFA4.

artículo científico publicado en 2016

Gut chemosensing mechanisms

artículo científico publicado en 2015

Hierarchical neural architecture underlying thirst regulation

artículo científico publicado en 2018

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells

artículo científico publicado en 2015

Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.

artículo científico publicado en 2009

Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model

artículo científico publicado en 2013

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

scientific article published on 04 December 2018

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

artículo científico publicado en 2020

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

artículo científico publicado en 2019

Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells

artículo científico publicado en 2021

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

artículo científico publicado en 2015

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

artículo científico publicado en 2019

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

artículo científico publicado en 2009

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

scientific journal article

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

artículo científico publicado en 2011

Intestinal sensing of nutrients

artículo científico

Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor

artículo científico publicado en 1999

Inwardly rectifying potassium channels.

artículo científico publicado en 1999

LKB1 and AMPK differentially regulate pancreatic β-cell identity.

artículo científico publicado en 2014

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

artículo científico publicado en 2015

Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like Peptide 1 neurons

artículo científico publicado en 2010

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

artículo científico publicado en 2015

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells

artículo científico publicado en 2015

Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues

artículo científico publicado en 2017

Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion

artículo científico publicado en 2016

Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

artículo científico publicado en 2017

Microbial regulation of the L cell transcriptome

artículo científico publicado en 2018

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

artículo científico publicado en 2017

Models and Tools for Studying Enteroendocrine Cells

Molecular determinants of KATP channel inhibition by ATP.

artículo científico publicado en 1998

Molecular mechanisms of incretin hormone secretion

artículo científico publicado en 2013

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

artículo científico publicado en 2012

Molecular mechanisms underlying nutrient detection by incretin-secreting cells

artículo científico publicado en 2010

Molecular mechanisms underlying nutrient-stimulated incretin secretion

artículo científico publicado en 2010

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis

scientific article published on 01 September 2018

Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic

artículo científico publicado en 2006

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion

artículo científico publicado en 2011

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression

artículo científico publicado en 2014

Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract

artículo científico publicado en 2012

No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis

artículo científico publicado en 2007

Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations

artículo científico publicado en 2015

Nutrient detection by incretin hormone secreting cells

artículo científico publicado en 2012

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

artículo científico publicado en 2009

Nutritional regulation of glucagon-like peptide-1 secretion

artículo científico publicado en 2008

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

artículo científico publicado en 2013

Open to control--new hope for patients with neonatal diabetes

artículo científico publicado en 2004

Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release

artículo científico publicado en 2017

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

artículo científico publicado en 2008

Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

artículo científico publicado en 2012

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

artículo científico publicado en 2012

PYY plays a key role in the resolution of diabetes following bariatric surgery in humans

artículo científico publicado en 2019

Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells.

artículo científico publicado en 2016

Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours

scientific article published on 01 August 2018

Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice

artículo científico publicado en 2021

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

scientific journal article

Placental secretome characterization identifies candidates for pregnancy complications

artículo científico publicado en 2021

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion.

artículo científico publicado en 2012

Pregnane glycosides from Cynanchum menarandrense

artículo científico publicado en 2017

Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem

artículo científico publicado en 2012

Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food

scientific article published on 02 October 2018

Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.

artículo científico publicado en 2016

Preproglucagon neurons project widely to autonomic control areas in the mouse brain.

artículo científico publicado en 2011

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

artículo científico publicado en 2016

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis

article

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights

artículo científico publicado en 2018

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

artículo científico publicado en 2005

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

artículo científico publicado en 2014

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes

scientific article published on December 2013

Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion

scientific article published on April 2016

Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells

artículo científico publicado en 2011

SCFAs strongly stimulate PYY production in human enteroendocrine cells.

artículo científico publicado en 2018

Scaling it down: new in vitro tools to get the balance right

artículo científico publicado en 2017

Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine

artículo científico publicado en 2020

Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse

artículo científico publicado en 2017

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

scientific journal article

Signalling in the gut endocrine axis

artículo científico publicado en 2017

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells

artículo científico publicado en 2015

Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine

artículo científico publicado en 2017

Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing

artículo científico publicado en 2006

Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.

artículo científico publicado en 2012

Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons

artículo científico publicado en 2014

Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1.

artículo científico publicado en 2014

Stimulation of incretin secreting cells

artículo científico publicado en 2016

Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion

artículo científico publicado en 2015

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

scientific article published on 24 January 2020

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

artículo científico publicado en 2008

Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies

artículo científico publicado en 2018

Targeting development of incretin-producing cells increases insulin secretion

artículo científico publicado en 2014

The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

artículo científico publicado en 2012

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

artículo científico publicado en 2014

The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1.

artículo científico publicado en 2017

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

artículo científico publicado en 2019

The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones

artículo científico publicado en 2016

The effect of encapsulated glutamine on gut peptide secretion in human volunteers

artículo científico publicado en 2015

The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel

artículo científico publicado en 2016

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

artículo científico publicado en 2014

The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line.

artículo científico publicado en 2005

The purification and amino acid sequence of the lethal neurotoxin Tx1 from the venom of the Brazilian 'armed' spider Phoneutria nigriventer

artículo científico publicado en 1990

The role of gut endocrine cells in control of metabolism and appetite

artículo científico publicado en 2014

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.

artículo científico publicado en 1999

The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release

artículo científico publicado en 2009

Towards the harnessing of gut feelings

artículo científico publicado en 2013

Transcriptional regulator PRDM12 is essential for human pain perception

artículo científico publicado en 2015

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

artículo científico publicado en 2016

Trophoblast organoids as a model for maternal-fetal interactions during human placentation

scientific article published on 28 November 2018

hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family

artículo científico publicado en 2000

α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin.

artículo científico publicado en 2015

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