Lista de obras - William B Klimstra - Dominio Público Uruguay

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

scientific journal article

A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection

artículo científico publicado en 2009

A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread

artículo científico publicado en 2016

A Vibrating Mesh Nebulizer as an Alternative to the Collison Three-Jet Nebulizer for Infectious Disease Aerobiology

scientific article published on 14 August 2019

A viral RNA structural element alters host recognition of nonself RNA

artículo científico publicado en 2014

Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor.

artículo científico publicado en 1998

Adaptation of alphaviruses to heparan sulfate: interaction of Sindbis and Semliki forest viruses with liposomes containing lipid-conjugated heparin

artículo científico publicado en 2002

Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection

artículo científico publicado en 2016

Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism

artículo científico publicado en 2008

Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism

artículo científico publicado en 2000

Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses

artículo científico publicado en 2017

Animal models for COVID-19

scientific article published on 23 September 2020

Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus

artículo científico publicado en 2017

Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis

scientific article published on 25 June 2020

Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule

artículo científico publicado en 2019

Attenuation of Sindbis virus variants incorporating uncleaved PE2 glycoprotein is correlated with attachment to cell-surface heparan sulfate

artículo científico publicado en 2004

Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses?

artículo científico publicado en 2014

Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus

artículo científico publicado en 2010

Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses.

artículo científico publicado en 2009

Closing the gap between viral and noninfectious arthritis

artículo científico publicado en 2014

Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions

artículo científico publicado en 2020

Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion

artículo científico publicado en 2004

Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus

artículo científico publicado en 2019

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization

artículo científico publicado en 2018

Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues

scientific article published on 03 April 2020

DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses

artículo científico publicado en 2003

DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses.

artículo científico publicado en 2004

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

artículo científico publicado en 2015

Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design

artículo científico publicado en 2014

Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease

artículo científico publicado en 2007

Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis.

artículo científico publicado en 2008

Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis

artículo científico publicado en 2002

Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses

scientific article published on 16 November 2019

Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System

artículo científico publicado en 2016

Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry

scientific article published on 11 February 2020

Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.

artículo científico publicado en 2018

Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence ⬇️

artículo científico publicado el 6 de septiembre de 2011

Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses

artículo científico publicado en 2007

Host responses to alphavirus infection

artículo científico publicado en 2008

Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus

artículo científico publicado en 2016

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

artículo científico publicado en 2020

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

artículo científico publicado en 2021

Human trophoblasts confer resistance to viruses implicated in perinatal infection

artículo científico publicado en 2014

Identification and characterization of interferon-induced proteins that inhibit alphavirus replication

scientific journal article

In vivo imaging in an ABSL-3 regional biocontainment laboratory

artículo científico publicado en 2014

Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome

artículo científico publicado en 1999

Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate.

artículo científico publicado en 2012

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus

artículo científico publicado en 2020

Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

artículo científico publicado en 2017

Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection

scientific article published on 26 November 2019

MicroRNA Regulation of RNA Virus Replication and Pathogenesis

artículo científico publicado en 2016

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

artículo científico publicado en 2020

Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host

artículo científico publicado en 2013

Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice

artículo científico publicado en 2000

Mxra8 is a receptor for multiple arthritogenic alphaviruses

artículo científico publicado en 2018

Natural variation in the heparan sulfate binding domain of the eastern equine encephalitis virus E2 glycoprotein alters interactions with cell surfaces and virulence in mice

artículo científico publicado en 2013

Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons

artículo científico publicado en 2007

PE2 cleavage mutants of Sindbis virus: correlation between viral infectivity and pH-dependent membrane fusion activation of the spike heterodimer

artículo científico publicado en 2001

Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions

scientific article published on 22 June 2020

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

artículo científico publicado en 2018

RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

artículo científico publicado en 2013

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

artículo científico publicado en 2019

Ribbon scanning confocal for high-speed high-resolution volume imaging of brain

artículo científico publicado en 2017

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

scientific article published on 21 August 2020

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

artículo científico publicado en 2020

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

scientific article published on 18 September 2020

Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses.

artículo científico publicado en 2009

Sindbis Virus Vectors Designed To Express a Foreign Protein as a Cleavable Component of the Viral Structural Polyprotein ⬇️

artículo científico publicado el 1 de mayo de 2003

Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells

artículo científico publicado en 2005

Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease

artículo científico publicado en 2013

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

artículo científico publicado en 2017

Targeting Sindbis virus-based vectors to Fc receptor-positive cell types

artículo científico publicado en 2005

The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells

artículo científico publicado en 2016

The 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functional

artículo científico publicado en 2015

The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent.

artículo científico publicado en 2018

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

artículo científico publicado en 2018

The expression level of C19MC miRNAs in early pregnancy and in response to viral infection

artículo científico publicado en 2017

The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate

artículo científico publicado en 1999

Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice

artículo científico publicado en 2009

Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats

artículo científico publicado en 2018

Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis

scientific article published on 13 September 2020

Lista de obras de William B Klimstra

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection

A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread

A Vibrating Mesh Nebulizer as an Alternative to the Collison Three-Jet Nebulizer for Infectious Disease Aerobiology

A viral RNA structural element alters host recognition of nonself RNA

Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor.

Adaptation of alphaviruses to heparan sulfate: interaction of Sindbis and Semliki forest viruses with liposomes containing lipid-conjugated heparin

Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection

Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism

Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism

Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses

Animal models for COVID-19

Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus

Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis

Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule

Attenuation of Sindbis virus variants incorporating uncleaved PE2 glycoprotein is correlated with attachment to cell-surface heparan sulfate

Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses?

Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus

Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses.

Closing the gap between viral and noninfectious arthritis

Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions

Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion

Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization

Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues

DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses

DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses.

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design

Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease

Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis.

Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis

Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses

Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System

Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry

Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.

Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence ⬇️

Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses

Host responses to alphavirus infection

Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

Human trophoblasts confer resistance to viruses implicated in perinatal infection

Identification and characterization of interferon-induced proteins that inhibit alphavirus replication

In vivo imaging in an ABSL-3 regional biocontainment laboratory

Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome

Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate.

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus

Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection

MicroRNA Regulation of RNA Virus Replication and Pathogenesis

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host

Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice

Mxra8 is a receptor for multiple arthritogenic alphaviruses

Natural variation in the heparan sulfate binding domain of the eastern equine encephalitis virus E2 glycoprotein alters interactions with cell surfaces and virulence in mice

Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons

PE2 cleavage mutants of Sindbis virus: correlation between viral infectivity and pH-dependent membrane fusion activation of the spike heterodimer

Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

Ribbon scanning confocal for high-speed high-resolution volume imaging of brain

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses.

Sindbis Virus Vectors Designed To Express a Foreign Protein as a Cleavable Component of the Viral Structural Polyprotein ⬇️

Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells

Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

Targeting Sindbis virus-based vectors to Fc receptor-positive cell types

The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells

The 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functional

The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent.

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

The expression level of C19MC miRNAs in early pregnancy and in response to viral infection

The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate

Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice