Lista de obras - Barrie Kellam - Dominio Público Uruguay

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.

artículo científico publicado en 2013

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells

artículo científico publicado en 2017

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

artículo científico publicado en 2018

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

artículo científico publicado en 2013

Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.

artículo científico publicado en 2007

Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications.

artículo científico publicado en 2016

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization

artículo científico publicado en 2014

Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery

artículo científico publicado en 2015

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

artículo científico publicado en 2004

CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans

artículo científico publicado en 2024

Cell-type-specific adhesion onto polymer surfaces from mixed cell populations.

artículo científico publicado en 2003

Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor.

artículo científico publicado en 2005

Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers.

artículo científico publicado en 2013

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.

artículo científico publicado en 2018

Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ)

artículo científico publicado en 2017

Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells

artículo científico publicado en 2011

Developing a self-healing supramolecular nucleoside hydrogel

artículo científico publicado en 2016

Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells

artículo científico publicado en 2018

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.

artículo científico publicado en 2015

Drug-like Antagonists of P2Y Receptors-From Lead Identification to Drug Development

artículo científico publicado en 2016

Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

artículo científico publicado en 2014

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

artículo científico publicado en 2018

Fluorophore-tagged GPCR ligands.

artículo científico publicado en 2005

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.

artículo científico publicado en 2016

Gelation properties of self-assembling N-acyl modified cytidine derivatives

scientific article published on 29 October 2014

Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.

artículo científico publicado en 2012

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

artículo científico publicado en 2020

Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone

scientific article published on 13 April 2011

Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications

artículo científico

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism

artículo científico publicado en 2014

Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells

artículo científico publicado en 2020

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

scientific article published on 31 March 2020

New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.

artículo científico publicado en 2007

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease.

artículo científico publicado en 2017

Nucleoside Based Self-Assembling Drugs for Localized Drug Delivery

artículo científico publicado en 2018

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

scientific article published on 07 January 2021

Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate

artículo científico publicado en 2014

Recent progress in the design of selectin inhibitors

artículo científico publicado en 2003

Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation.

artículo científico publicado en 2018

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

scientific article published on 23 October 2019

Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels

artículo científico publicado en 2021

Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor

artículo científico publicado en 2020

Surface engineering of living myoblasts via selective periodate oxidation.

artículo científico publicado en 2003

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.

artículo científico publicado en 2018

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

artículo científico

Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.

artículo científico publicado en 2013

Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold

artículo científico publicado en 2015

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

artículo científico publicado en 2015

The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs

artículo científico publicado en 2014

Lista de obras de Barrie Kellam

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.

Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications.

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization

Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans

Cell-type-specific adhesion onto polymer surfaces from mixed cell populations.

Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor.

Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers.

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.

Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ)

Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells

Developing a self-healing supramolecular nucleoside hydrogel

Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.

Drug-like Antagonists of P2Y Receptors-From Lead Identification to Drug Development

Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

Fluorophore-tagged GPCR ligands.

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.

Gelation properties of self-assembling N-acyl modified cytidine derivatives

Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone

Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism

Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease.

Nucleoside Based Self-Assembling Drugs for Localized Drug Delivery

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate

Recent progress in the design of selectin inhibitors

Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation.

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels

Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor

Surface engineering of living myoblasts via selective periodate oxidation.

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.

Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs