Lista de obras -

1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression

artículo científico publicado en 2017

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells

artículo científico publicado en 2013

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway

scientific article published in 2018

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

artículo científico publicado en 2014

A crucial role for primary cilia in cortical morphogenesis

scientific journal article

A deadly organometallic luminescent probe: anticancer activity of a ReI bisquinoline complex.

artículo científico publicado en 2014

A fast and efficient polymerase chain reaction‐based method for the preparation of in situ hybridization probes ⬇️

artículo científico publicado el 28 de marzo de 2012

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

artículo científico publicado en 2016

A multi-target gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells

artículo científico publicado en 2020

Acidic stress induced G1 cell cycle arrest and intrinsic apoptotic pathway in Jurkat T-lymphocytes

artículo científico publicado en 2016

Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics

artículo científico publicado en 2018

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

artículo científico publicado en 2015

Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes

artículo científico publicado en 2011

Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

artículo científico publicado en 2020

Author Correction: Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

artículo científico publicado en 2018

BMP2 Transfer to Neighboring Cells and Activation of Signaling

artículo científico publicado en 2016

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

artículo científico publicado en 2010

Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl‐Substituted Phenanthroline Ligands ⬇️

artículo científico publicado el 17 de febrero de 2011

Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts

artículo científico publicado en 2012

Cellular uptake, cytotoxicity, and metabolic profiling of human cancer cells treated with ruthenium(II) polypyridyl complexes [Ru(bpy)2(N--N)]Cl2 with N--N=bpy, phen, dpq, dppz, and dppn

artículo científico publicado en 2008

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

artículo científico publicado en 2011

Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3 ⬇️

artículo científico publicado el 13 de junio de 2010

Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

article

Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands ⬇️

artículo científico publicado el 14 de marzo de 2012

Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform

artículo científico publicado en 2017

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

artículo científico publicado en 2014

Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types

artículo científico publicado en 2018

Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells.

artículo científico publicado en 2017

Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2.

artículo científico

Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain ⬇️

artículo científico publicado el 2 de julio de 2012

Effects of 1,25(OH)₂D₃ on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents.

artículo científico publicado en 2017

Enhanced cellular uptake and cytotoxicity studies of organometallic bioconjugates of the NLS peptide in Hep G2 cells

artículo científico publicado en 2009

Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

artículo científico publicado en 2017

Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis

artículo científico publicado en 2018

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4.

artículo científico publicado en 2015

Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

artículo científico publicado en 2012

Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts

artículo científico publicado en 2016

Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)₂D₃: Is It Really the Vitamin D₃ Upregulated Protein?

artículo científico publicado en 2018

FeIII(salophene)Cl, a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells ⬇️

artículo científico publicado el 4 de diciembre de 2010

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

artículo científico publicado en 2018

From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

artículo científico publicado en 2011

Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae

artículo científico publicado en 2006

Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity

artículo científico publicado en 2009

Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators

artículo científico publicado en 2014

Golgi stress mediates redox imbalance and ferroptosis in human cells

artículo científico publicado en 2018

Guidelines and recommendations on yeast cell death nomenclature.

artículo científico publicado en 2018

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

artículo científico publicado en 2011

Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling

artículo científico publicado en 2008

Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis

artículo científico publicado en 2017

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers

artículo científico publicado en 2015

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

artículo científico publicado en 2017

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells

artículo científico publicado en 2015

In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform

scientific article published on 15 March 2019

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

artículo científico publicado en 2012

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

article

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

artículo científico publicado en 2017

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

scientific article published on 28 April 2022

Metabolic response to MMS-mediated DNA damage in Saccharomyces cerevisiae is dependent on the glucose concentration in the medium

artículo científico publicado en 2009

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

artículo científico publicado en 2016

Microfluidic devices for stem-cell cultivation, differentiation and toxicity testing

artículo científico publicado en 2017

Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes

artículo científico publicado en 2016

Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.

artículo científico publicado en 2017

Multimodal Eph/Ephrin signaling controls several phases of urogenital development

artículo científico publicado en 2016

Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress

artículo científico publicado en 2017

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice

scientific article published on 03 January 2020

On the biological properties of alkynyl phosphine gold(I) complexes.

artículo científico publicado en 2012

Procarcinogens - Determination and Evaluation by Yeast-Based Biosensor Transformed with Plasmids Incorporating RAD54 Reporter Construct and Cytochrome P450 Genes

artículo científico publicado en 2016

Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.

artículo científico publicado en 2014

Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists ⬇️

artículo científico publicado el 17 de octubre de 2012

Real-Time Monitoring of Cisplatin-Induced Cell Death ⬇️

artículo científico publicado el 16 de mayo de 2011

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

artículo científico publicado en 2015

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability

artículo científico publicado en 2010

Structure-activity relationship of trifluoromethyl-containing metallocenes: electrochemistry, lipophilicity, cytotoxicity, and ROS production

artículo científico publicado en 2014

Synthesis and cellular impact of diene-ruthenium(II) complexes: a new class of organoruthenium anticancer agents

artículo científico publicado en 2011

Synthesis, biological activity, and structure-activity relationships for potent cytotoxic rhodium(III) polypyridyl complexes

artículo científico publicado en 2008

The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity

artículo científico publicado en 2015

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

artículo científico publicado en 2014

Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates

artículo científico publicado en 2015

Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy

artículo científico publicado en 2017

Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse

artículo científico publicado en 2013

[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties

artículo científico publicado en 2009

[NiII(3-OMe-salophene)]: a potent agent with antitumor activity

artículo científico publicado en 2010

p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells.

artículo científico publicado en 2019

Lista de obras de

1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

A crucial role for primary cilia in cortical morphogenesis

A deadly organometallic luminescent probe: anticancer activity of a ReI bisquinoline complex.

A fast and efficient polymerase chain reaction‐based method for the preparation of in situ hybridization probes ⬇️

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

A multi-target gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells

Acidic stress induced G1 cell cycle arrest and intrinsic apoptotic pathway in Jurkat T-lymphocytes

Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes

Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

Author Correction: Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

BMP2 Transfer to Neighboring Cells and Activation of Signaling

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl‐Substituted Phenanthroline Ligands ⬇️

Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts

Cellular uptake, cytotoxicity, and metabolic profiling of human cancer cells treated with ruthenium(II) polypyridyl complexes [Ru(bpy)2(N--N)]Cl2 with N--N=bpy, phen, dpq, dppz, and dppn

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3 ⬇️

Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands ⬇️

Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types

Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells.

Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2.

Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain ⬇️

Effects of 1,25(OH)₂D₃ on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents.

Enhanced cellular uptake and cytotoxicity studies of organometallic bioconjugates of the NLS peptide in Hep G2 cells

Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4.

Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts

Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)₂D₃: Is It Really the Vitamin D₃ Upregulated Protein?

FeIII(salophene)Cl, a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells ⬇️

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae

Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity

Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators

Golgi stress mediates redox imbalance and ferroptosis in human cells

Guidelines and recommendations on yeast cell death nomenclature.

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling

Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells

In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

Metabolic response to MMS-mediated DNA damage in Saccharomyces cerevisiae is dependent on the glucose concentration in the medium

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

Microfluidic devices for stem-cell cultivation, differentiation and toxicity testing

Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes

Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.

Multimodal Eph/Ephrin signaling controls several phases of urogenital development

Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice

On the biological properties of alkynyl phosphine gold(I) complexes.

Procarcinogens - Determination and Evaluation by Yeast-Based Biosensor Transformed with Plasmids Incorporating RAD54 Reporter Construct and Cytochrome P450 Genes

Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.

Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists ⬇️

Real-Time Monitoring of Cisplatin-Induced Cell Death ⬇️

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability

Structure-activity relationship of trifluoromethyl-containing metallocenes: electrochemistry, lipophilicity, cytotoxicity, and ROS production

Synthesis and cellular impact of diene-ruthenium(II) complexes: a new class of organoruthenium anticancer agents

Synthesis, biological activity, and structure-activity relationships for potent cytotoxic rhodium(III) polypyridyl complexes

The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates

Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy