Lista de obras -

3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells

artículo científico publicado en 2011

30 Purification of platelet-derived growth factor β receptor from porcine uterus

artículo científico publicado el 1 de enero de 1991

A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML.

artículo científico publicado en 2009

A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis

scientific article published on 01 February 1994

A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex

artículo científico publicado en 1994

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.

artículo científico publicado en 2017

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.

artículo científico

Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF.

artículo científico publicado en 2001

BEX1 acts as a tumor suppressor in acute myeloid leukemia.

artículo científico

Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis

scientific article published on 01 November 2000

Brain-Expressed X-linked (BEX) proteins in human cancers.

artículo científico

Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma

scientific article published on 16 July 2018

C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation

artículo científico publicado en 2011

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein

scientific article published on 01 November 1999

Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase

scientific article published on 01 August 1983

Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor

artículo científico publicado en 1988

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

artículo científico publicado en 2003

Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism.

artículo científico publicado en 2006

Correction: The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia

artículo científico publicado en 2019

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

artículo científico publicado en 2018

Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors

artículo científico publicado en 1995

Deregulation of protein phosphatase expression in acute myeloid leukemia ⬇️

artículo científico publicado el 26 de febrero de 2013

Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.

artículo científico publicado en 2013

Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

artículo científico publicado en 2000

Dysfunctionality of a tobacco mosaic virus movement protein mutant mimicking threonine 104 phosphorylation

artículo científico publicado en 2003

EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation

artículo científico publicado en 2014

Enhanced SOX10 and KIT expression in cutaneous melanoma.

artículo científico publicado en 2013

Expression of GADS enhances FLT3-induced mitogenic signaling.

artículo científico publicado en 2016

Expression of Platelet-Derived Growth Factor Receptors is Induced on Connective Tissue Cells During Chronic Synovial Inflammation

artículo científico publicado en 1988

FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL).

artículo científico publicado en 2013

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

artículo científico publicado en 2012

FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

scientific article published on 01 July 2019

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

artículo científico publicado en 2016

Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes.

artículo científico publicado en 1999

HIF-2α Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1α Is Repressed ⬇️

artículo científico publicado el 21 de noviembre de 2011

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.

artículo científico publicado en 2016

Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation.

artículo científico publicado en 2006

Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro ⬇️

artículo científico publicado el 2 de enero de 1998

Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

artículo científico publicado en 1998

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

scientific article published on 09 May 2006

Identification of protein tyrosine phosphatases associating with the PDGF receptor

artículo científico publicado en 2003

Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells

scientific journal article

Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol

scientific article published on 01 May 1996

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases ⬇️

artículo científico publicado el 1 de junio de 1993

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

scientific journal article

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

artículo científico publicado en 1993

Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.

artículo científico publicado en 1988

Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

artículo científico publicado en 2011

Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor.

artículo científico publicado en 2006

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation

artículo científico publicado en 2018

Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.

artículo científico publicado en 1997

Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice

artículo científico publicado en 2011

Keratin 19 expression correlates with poor prognosis in breast cancer

artículo científico publicado en 2014

Metallopeptidase inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

artículo científico publicado en 2019

Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C

scientific journal article

Molecular Basis for the Dominant White Phenotype in the Domestic Pig ⬇️

artículo científico publicado el 1 de agosto de 1998

Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.

artículo científico publicado en 1999

PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.

artículo científico publicado en 1997

PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner

artículo científico publicado en 2015

Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant

scientific journal article

Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection.

artículo científico publicado en 2003

Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

artículo científico publicado en 1997

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.

artículo científico publicado en 2001

Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.

artículo científico publicado en 1989

Platelet-derived growth factor: mechanism of action and relation to oncogenes.

artículo científico publicado en 1985

Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.

artículo científico publicado en 2013

Protein kinase C expression is deregulated in chronic lymphocytic leukemia.

artículo científico publicado en 2013

Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling ⬇️

artículo científico publicado el 24 de enero de 2011

Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan ⬇️

artículo científico publicado el 5 de diciembre de 1991

Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes.

artículo científico publicado en 1991

Receptor association and tyrosine phosphorylation of S6 kinases.

artículo científico publicado en 2006

Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

artículo científico publicado en 2015

SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis

artículo científico publicado en 1999

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor

artículo científico publicado en 2002

SOCS proteins in regulation of receptor tyrosine kinase signaling

artículo científico

SOCS6 is a selective suppressor of receptor tyrosine kinase signaling

artículo científico publicado en 2014

SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation

artículo científico publicado en 2018

Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.

artículo científico publicado en 2002

Signal transduction via platelet-derived growth factor receptors ⬇️

artículo científico publicado el 19 de agosto de 1998

Signal transduction via the stem cell factor receptor/c-Kit

artículo científico publicado en 2004

Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.

artículo científico publicado en 2012

Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling

artículo científico publicado en 2016

Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling.

artículo científico publicado en 2013

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications ⬇️

artículo científico publicado el 1 de octubre de 2012

Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.

artículo científico publicado en 2008

Stimulation of tyrosine phosphorylation by platelet-derived growth factor

scientific article published on 01 October 1984

Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.

artículo científico publicado en 1996

Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling ⬇️

artículo científico publicado el 19 de marzo de 2013

The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia

scholarly article by Sausan A Moharram et al published 15 January 2019 in Blood Cancer Journal

The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.

artículo científico publicado en 2013

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

artículo científico publicado en 2015

The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

artículo científico publicado en 2017

The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V.

artículo científico publicado en 2014

The basic helix-loop-helix (bHLH) proteins in breast cancer progression ⬇️

artículo científico publicado el 23 de julio de 2013

The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.

artículo científico publicado en 2008

The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate.

artículo científico publicado en 2007

The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome.

artículo científico publicado en 2013

The role of HOXB2 and HOXB3 in acute myeloid leukemia.

artículo científico publicado en 2015

The role of SRC family kinases in FLT3 signaling

artículo científico publicado en 2018

The stem cell factor receptor/c-Kit as a drug target in cancer

artículo científico publicado en 2006

The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling ⬇️

artículo científico publicado el 21 de mayo de 2013

Tissue distribution of macrophages, class II transplantation antigens, and receptors for platelet-derived growth factor in normal and rejected human kidneys

artículo científico publicado en 1987

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

artículo científico publicado en 1994

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.

artículo científico publicado en 2017

Why and how to investigate the role of protein phosphorylation in ZIP and ZnT zinc transporter activity and regulation

artículo científico publicado en 2020

XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation.

artículo científico publicado en 2018

p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils

artículo científico publicado en 2004

Lista de obras de

3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells

30 Purification of platelet-derived growth factor β receptor from porcine uterus

A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML.

A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis

A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.

Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF.

BEX1 acts as a tumor suppressor in acute myeloid leukemia.

Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis

Brain-Expressed X-linked (BEX) proteins in human cancers.

Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma

C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein

Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase

Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism.

Correction: The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors

Deregulation of protein phosphatase expression in acute myeloid leukemia ⬇️

Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.

Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

Dysfunctionality of a tobacco mosaic virus movement protein mutant mimicking threonine 104 phosphorylation

EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation

Enhanced SOX10 and KIT expression in cutaneous melanoma.

Expression of GADS enhances FLT3-induced mitogenic signaling.

Expression of Platelet-Derived Growth Factor Receptors is Induced on Connective Tissue Cells During Chronic Synovial Inflammation

FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL).

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes.

HIF-2α Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1α Is Repressed ⬇️

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.

Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation.

Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro ⬇️

Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

Identification of protein tyrosine phosphatases associating with the PDGF receptor

Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells

Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases ⬇️

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.

Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor.

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation

Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.

Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice

Keratin 19 expression correlates with poor prognosis in breast cancer

Metallopeptidase inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C

Molecular Basis for the Dominant White Phenotype in the Domestic Pig ⬇️

Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.

PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.

PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner

Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant

Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection.

Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.

Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.

Platelet-derived growth factor: mechanism of action and relation to oncogenes.

Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.

Protein kinase C expression is deregulated in chronic lymphocytic leukemia.

Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling ⬇️

Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan ⬇️

Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes.

Receptor association and tyrosine phosphorylation of S6 kinases.

Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor

SOCS proteins in regulation of receptor tyrosine kinase signaling

SOCS6 is a selective suppressor of receptor tyrosine kinase signaling

SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation

Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.

Signal transduction via platelet-derived growth factor receptors ⬇️