Lista de obras -

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

artículo científico publicado en 2007

Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release.

artículo científico publicado en 1984

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

artículo científico publicado en 2012

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System ⬇️

artículo científico publicado en 2018

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs ⬇️

artículo científico publicado en 2017

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

artículo científico publicado en 2015

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

artículo científico publicado en 2014

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data. ⬇️

artículo científico publicado en 2018

Fragment screening to predict druggability (ligandability) and lead discovery success.

artículo científico publicado en 2011

Interactions between discrete neuronal membrane binding sites for the putative K+-channel ligands beta-bungarotoxin, dendrotoxin and mast-cell-degranulating peptide

scientific article published on 01 January 1989

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. ⬇️

artículo científico publicado en 2016

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence ⬇️

artículo científico publicado en 2015

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1 ⬇️

artículo científico publicado el 17 de enero de 2013

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074. ⬇️

artículo científico publicado en 2018

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

artículo científico publicado en 2021

Real-time monitoring of New Delhi metallo-β-lactamase activity in living bacterial cells by 1H NMR spectroscopy ⬇️

artículo científico publicado en 2014

Secondary structure and backbone dynamics of human granulocyte colony-stimulating factor in solution

scientific article published on 01 June 1994

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation ⬇️

artículo científico publicado en 2015

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction ⬇️

artículo científico publicado en 2014

Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.

artículo científico publicado en 1991

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase ⬇️

artículo científico publicado en 2015

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4

artículo científico publicado en 2014

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase

artículo científico publicado en 1996

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting ⬇️

artículo científico publicado en 2018

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

artículo científico publicado en 2005

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups ⬇️

artículo científico publicado en 2016

Target-based whole-cell screening by ¹H NMR spectroscopy ⬇️

artículo científico publicado en 2015

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs ⬇️

artículo científico publicado en 2019

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics ⬇️

artículo científico publicado en 2016

¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH.

artículo científico publicado en 2012

Lista de obras de

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release.

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System ⬇️

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs ⬇️

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data. ⬇️

Fragment screening to predict druggability (ligandability) and lead discovery success.

Interactions between discrete neuronal membrane binding sites for the putative K+-channel ligands beta-bungarotoxin, dendrotoxin and mast-cell-degranulating peptide

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. ⬇️

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence ⬇️

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1 ⬇️

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074. ⬇️

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Real-time monitoring of New Delhi metallo-β-lactamase activity in living bacterial cells by 1H NMR spectroscopy ⬇️

Secondary structure and backbone dynamics of human granulocyte colony-stimulating factor in solution

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation ⬇️

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction ⬇️

Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase ⬇️

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting ⬇️

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups ⬇️

Target-based whole-cell screening by ¹H NMR spectroscopy ⬇️

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs ⬇️

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics ⬇️

¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH.