Lista de obras - Marc P Hübner - Dominio Público Uruguay

A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.

artículo científico publicado en 2015

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis

scientific article published on 05 November 2010

Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis

artículo científico publicado en 2013

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

artículo científico publicado en 2019

Chronic Helminth Infection Reduces Basophil Responsiveness in an IL-10–Dependent Manner ⬇️

artículo científico publicado el 28 de marzo de 2012

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

artículo científico publicado en 2015

Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis.

artículo científico publicado en 2016

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

artículo científico publicado en 2018

Comparative study on serum-induced arthritis in the temporomandibular and limb joint of mice

scientific article published on 21 January 2019

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

artículo científico publicado en 2020

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

scientific article published on 28 February 2019

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

scientific article published on 01 May 2019

Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients.

artículo científico publicado en 2006

Eotaxin-1 is involved in parasite clearance during chronic filarial infection

artículo científico publicado en 2014

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice.

artículo científico publicado en 2016

Filarial extract of Litomosoides sigmodontis induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE-knockout mice

scientific article published on 26 February 2019

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

artículo científico publicado en 2022

Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases

artículo científico publicado en 2015

Genome-wide transcriptome induced by nickel in human monocytes

artículo científico publicado en 2016

Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF-β ⬇️

artículo científico publicado el 14 de diciembre de 2011

Helminth infection is associated with decreased basophil responsiveness in human beings ⬇️

artículo científico publicado el 16 de mayo de 2012

Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms

artículo científico publicado en 2015

IL-6 is required for protective immune responses against early filarial infection

artículo científico publicado en 2018

Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response

artículo científico publicado en 2011

Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

artículo científico publicado en 2016

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

scientific article published on 27 January 2020

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

artículo científico publicado en 2019

Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (Meriones unguiculatus).

artículo científico publicado en 2009

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

artículo científico publicado en 2019

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

artículo científico publicado en 2016

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

artículo científico publicado en 2020

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes.

artículo científico publicado en 2015

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

artículo científico publicado en 2019

Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation

scientific article published on 13 November 2019

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis

scientific article published on 27 February 2020

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

scientific article published on 20 May 2019

Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels

artículo científico publicado en 2019

Lista de obras de Marc P Hübner

A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis

Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Chronic Helminth Infection Reduces Basophil Responsiveness in an IL-10–Dependent Manner ⬇️

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis.

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

Comparative study on serum-induced arthritis in the temporomandibular and limb joint of mice

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients.

Eotaxin-1 is involved in parasite clearance during chronic filarial infection

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice.

Filarial extract of Litomosoides sigmodontis induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE-knockout mice

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases

Genome-wide transcriptome induced by nickel in human monocytes

Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF-β ⬇️

Helminth infection is associated with decreased basophil responsiveness in human beings ⬇️

Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms

IL-6 is required for protective immune responses against early filarial infection

Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response

Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (Meriones unguiculatus).

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes.

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels