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Lista de obras de Mark Peakman

203 Preliminary therapeutic target validation of the IL-36 receptor in psoriasis

scholarly article by S.K. Mahil published in October 2017

3 beta hydroxysteroid dehydrogenase autoantibodies in patients with idiopathic premature ovarian failure target N- and C-terminal epitopes

scientific article published on 01 December 2001

A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding

artículo científico publicado en 2016

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.

artículo científico publicado en 2015

A model for harmonizing flow cytometry in clinical trials

artículo científico publicado en 2010

A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping

artículo científico

A single autoimmune T cell receptor recognizes more than a million different peptides

artículo científico publicado en 2011

A systematic review and critical evaluation of the immunology of chronic fatigue syndrome

artículo científico publicado en 2003

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

artículo científico publicado en 2016

An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target.

artículo científico publicado en 2017

Anti-TNFalpha therapy--killing two birds with one stone?

artículo científico publicado en 2010

Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice

artículo científico publicado en 2012

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

artículo científico publicado en 2014

Antigen targets of type 1 diabetes autoimmunity

artículo científico publicado en 2012

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

scientific article published on 24 October 2018

Antigen-specific immunotherapy and influenza vaccination in type 1 diabetes: timing is everything.

artículo científico publicado en 2017

Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential

artículo científico publicado en 2010

Antinuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients.

artículo científico publicado en 2002

Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic -Cell-Specific CD8 T-Cells

article

Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy

artículo científico publicado en 2005

Autoreactive T cells in human type 1 diabetes.

artículo científico publicado en 2004

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.

artículo científico publicado en 2018

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes

artículo científico publicado en 2014

Broadening the translational immunology landscape

artículo científico publicado en 2012

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

artículo científico publicado en 2008

Can we vaccinate against Type 1 diabetes?

artículo científico publicado en 2012

Cellular immune activation in Gulf War veterans

artículo científico publicado en 2004

Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop fo

artículo científico publicado en 2001

Characterization of the T-cell response to coxsackievirus B4: evidence that effector memory cells predominate in patients with type 1 diabetes.

artículo científico publicado en 2002

Characterization of the autoimmune response against the nerve tissue S100β in patients with type 1 diabetes.

artículo científico publicado en 2015

Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells

artículo científico publicado en 2012

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

scientific article published on 10 November 2019

Clinical improvement in chronic fatigue syndrome is not associated with lymphocyte subsets of function or activation.

artículo científico publicado en 1997

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop

artículo científico publicado en 2003

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

artículo científico publicado en 2014

Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy

scientific article published on 22 March 2019

Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding

artículo científico publicado en 2017

Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment

artículo científico publicado en 2013

Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: update on islet biology and transplantation.

artículo científico publicado en 2014

Cytokine overproduction in healthy first degree relatives of patients with IDDM

artículo científico publicado en 1998

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

artículo científico publicado en 2005

Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.

artículo científico publicado en 2016

Diabetogenic T lymphocytes in human Type 1 diabetes

artículo científico publicado en 2011

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations

artículo científico publicado en 2012

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.

artículo científico publicado en 2015

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.

artículo científico publicado en 2011

Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes

artículo científico publicado en 2013

Enteroviruses and type 1 diabetes

artículo científico publicado en 2003

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845

artículo científico publicado en 2015

Establishing humanized mice using stem cells: maximizing the potential

artículo científico publicado en 2008

Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets

artículo científico publicado en 2010

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells

artículo científico publicado en 2020

Generation of human islet-specific regulatory T cells by TCR gene transfer

artículo científico publicado en 2017

Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo

scientific article published on 21 May 2013

HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides.

artículo científico publicado en 2005

Heterogeneity in the Locomotory Behavior of Human Monocyte Subsets over Human Vascular Endothelium In Vitro

artículo científico publicado en 2015

High levels of type 2 cytokine-producing cells in chronic fatigue syndrome

artículo científico publicado en 2004

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

artículo científico publicado en 2016

How Representative Are Research Tissue Biobanks of the Local Populations? Experience of the Infectious Diseases Biobank at King's College, London, UK

artículo científico publicado en 2011

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

artículo científico publicado en 2012

Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy

scientific article published on 17 November 2008

Hydrophobic CDR3 residues promote the development of self-reactive T cells

artículo científico publicado en 2016

Identification and characterisation of peptide binding motifs of six autoimmune disease-associated human leukocyte antigen-class I molecules including HLA-B*39:06.

artículo científico publicado en 2014

Identification of a naturally processed cytotoxic CD8 T-cell epitope of coxsackievirus B4, presented by HLA-A2.1 and located in the PEVKEK region of the P2C nonstructural protein

artículo científico publicado en 2004

Immunogenicity of human embryonic stem cell-derived beta cells.

artículo científico publicado en 2016

Immunological dysfunction, vaccination and Gulf War illness

artículo científico publicado en 2006

Immunological pathways to β-cell damage in Type 1 diabetes

artículo científico publicado en 2013

In silico and ex vivo approaches indicate immune pressure on capsid and non-capsid regions of coxsackie B viruses in the human system.

artículo científico publicado en 2018

Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

scientific article published on 01 December 2008

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy

artículo científico publicado en 2015

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

artículo científico publicado en 2019

Lack of association between HLA genotype and chronic fatigue syndrome

article

Level of major histocompatibility complex class I expression on endothelium in non-obese diabetic mice influences CD8 T cell adhesion and migration

artículo científico publicado en 2009

Long-lasting T cell responses to biological warfare vaccines in human vaccinees

artículo científico publicado en 2006

Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial

artículo científico publicado en 2011

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes.

artículo científico publicado en 2017

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

artículo científico publicado en 2010

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

artículo científico publicado en 2018

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

artículo científico publicado en 2015

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

artículo científico publicado en 2014

Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression

artículo científico publicado en 2010

Optimization of current and future therapy for autoimmune diseases

artículo científico publicado en 2012

Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

Paraoxonase in Persian Gulf War veterans

artículo científico publicado en 2003

Peptide length determines the outcome of TCR/peptide-MHCI engagement

artículo científico publicado en 2013

Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.

artículo científico publicado en 2018

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death

scientific journal article

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

artículo científico publicado en 2015

Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture

artículo científico publicado en 2008

Possession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infection

artículo científico publicado en 2004

Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell

artículo científico publicado en 2009

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

artículo científico publicado en 2013

Prevalence of anti-N-methyl-D-aspartate (NMDA) receptor [corrected] antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-analysis

artículo científico publicado en 2014

Primary and immortalised human pancreatic islet endothelial cells: phenotypic and immunological characterisation.

artículo científico publicado en 2005

Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells

artículo científico publicado en 2003

Progress in immune-based therapies for type 1 diabetes

artículo científico

Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model.

artículo científico publicado en 2015

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.

artículo científico publicado en 2008

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

scientific article published on 14 October 2019

Proinsulin-mediated induction of type 1 diabetes in HLA-DR4-transgenic mice

artículo científico publicado en 2018

Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules

scientific article published on 09 April 2003

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

artículo científico publicado en 2008

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity

artículo científico publicado en 2016

Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline

artículo científico publicado en 2014

Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?

artículo científico publicado en 2017

Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.

artículo científico publicado en 2018

Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

artículo científico publicado en 2012

Reversed-polarity T(reg) cell TCRs provide a shock

artículo científico publicado en 2015

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

artículo científico publicado en 2010

Stimulated urine C-peptide creatinine ratio vs serum C-peptide level for monitoring of β-cell function in the first year after diagnosis of Type 1 diabetes

artículo científico publicado en 2016

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

artículo científico publicado en 2012

Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes

artículo científico publicado en 2010

Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis

scientific article published on 20 January 2020

T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes.

artículo científico publicado en 2017

T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review

artículo científico

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.

artículo científico publicado en 2016

The challenge of modulating β-cell autoimmunity in type 1 diabetes

scientific article published on 24 October 2018

The development of new density gradient media for purifying human islets and islet-quality assessments

artículo científico publicado en 2004

The habitual, diverse and surmountable obstacles to human immunology research

scientific article published on 01 June 2008

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

artículo científico publicado en 2012

Understanding and preventing type 1 diabetes through the unique working model of TrialNet

artículo científico publicado en 2017

Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.

artículo científico publicado en 2009

Variation of Peripheral Blood Mononuclear Cell RNA Quality in Archived Samples

artículo científico publicado en 2011

β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults

artículo científico publicado en 2016

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

artículo científico publicado en 2014