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A Specific Inhibitor of Cytosolic Phospholipase A2Activity, AACOCF3, Inhibits Glucose-Induced Insulin Secretion from Isolated Rat Islets

article

A comparison of cytosolic phospholipase A2 expression in human islets of Langerhans and rodent insulin-secreting cells.

artículo científico publicado en 1994

A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID).

artículo científico publicado en 2017

Abnormal islet sphingolipid metabolism in type 1 diabetes.

artículo científico publicado en 2018

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

artículo científico publicado en 2018

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

artículo científico publicado en 2014

Activation of Protein Kinase C Modulates α2-Adrenergic Signalling in Rat Pancreatic Islets

article

Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.

artículo científico publicado en 1995

Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats

artículo científico publicado en 1983

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

artículo científico publicado en 2017

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

artículo científico publicado en 2015

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

scientific article published on 22 May 2020

Analysis of islet inflammation in human type 1 diabetes.

artículo científico publicado en 2009

Angiotensin II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects

artículo científico publicado en 1983

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

artículo científico publicado en 2011

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes

artículo científico publicado en 2014

Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes.

artículo científico publicado en 2017

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

artículo científico publicado en 2018

Calcium handling by stimulated islets of Langerhans

scientific article published on 01 February 1989

Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns

artículo científico publicado en 2019

Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites.

artículo científico publicado en 1998

Characterisation of the α1-adrenergic control of hepatic cAMP in male rats

article

Characterization of monoamine oxidase isoforms in human islets of langerhans

artículo científico publicado en 1999

Characterization of the imidazoline binding site involved in regulation of insulin secretion.

artículo científico publicado en 1995

Combining enteral with parenteral nutrition to improve postoperative glucose control

artículo científico publicado en 2010

Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells

artículo científico publicado en 2006

Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion

scientific article published on 01 May 2011

Control of insulin secretion by imidazolines in rat pancreatic islets

scientific article published on 01 May 1993

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

artículo científico publicado en 2017

Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes

artículo científico publicado en 2014

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

artículo científico publicado en 2014

Differential Expression of α2-Adrenoceptor Subtypes in Purified Rat Pancreatic Islet A- and B-Cells

artículo científico publicado en 1997

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

artículo científico publicado en 2016

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

artículo científico publicado en 2015

Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells.

artículo científico publicado en 2002

Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells

artículo científico publicado en 2013

Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate

artículo científico publicado en 2006

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell

artículo científico publicado en 2008

Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids

artículo científico publicado en 2008

Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans

artículo científico publicado en 2000

Dissociation between intracellular calcium mobilization and insulin secretion in isolated rat islets of Langerhans

artículo científico publicado en 1988

Down-regulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration

artículo científico publicado en 2011

Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans.

artículo científico publicado en 1985

Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats.

artículo científico publicado en 1999

Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans.

artículo científico publicado en 1998

Effects of benextramine on the adrenergic inhibition of insulin secretion in isolated rat pancreatic islets

scientific article published on 01 March 1989

Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic ?-cells

artículo científico publicado en 2000

Effects of noradrenaline on45Ca2+ efflux from isolated rat islets of Langerhans

article

Effects of phenoxybenzamine on insulin secretion from isolated rat islets of Langerhans

artículo científico publicado en 1989

Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans

artículo científico publicado en 2003

Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.

artículo científico publicado en 2003

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention

artículo científico publicado en 2018

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

artículo científico publicado en 2014

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845

artículo científico publicado en 2015

Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.

artículo científico publicado en 2013

Evidence for differential effects of noradrenaline and somatostatin on intracellular messenger systems in rat islets of Langerhans

artículo científico publicado en 1990

Evidence for the presence of low molecular mass GTP-binding proteins in rat islets of Langerhans

scientific article published on 01 June 1990

Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with sigma receptors.

artículo científico publicado en 1997

Evidence that the presence of arginine can lead to overestimation of glucagon levels measured by radioimmunoassay.

artículo científico publicado en 1992

Expression and functional activity of PPARgamma in pancreatic beta cells

artículo científico publicado en 2004

Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells

artículo científico publicado en 2010

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

scientific article published on 14 October 2012

Fatty acids and beta-cell toxicity

artículo científico publicado en 2009

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

scholarly article by Noel G Morgan et al published 1 December 2018 in Diabetologia

Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 β-cells

scientific article published on 01 August 2003

G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell

scientific article published on 04 August 2009

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

artículo científico publicado en 2014

GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell

artículo científico publicado en 2002

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes

artículo científico publicado en 2017

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

scientific article published on 04 March 2019

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

scientific journal article

Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways

artículo científico publicado en 2009

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation

scientific article published on 01 May 1998

Identification and Characterization of Non-Adrenergic Binding Sites in Insulin-Secreting Cells with the Imidazoline RX821002 ⬇️

artículo científico publicado el 1 de enero de 1997

Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell

artículo científico publicado en 2002

Imidazoleacetic acid-ribotide: An endogenous ligand that stimulates imidazol(in)e receptors

artículo científico publicado en 2004

Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues?

artículo científico publicado en 2001

Imidazoline receptors: new targets for antihyperglycaemic drugs.

artículo científico publicado en 1999

Imidazolines and pancreatic hormone secretion.

artículo científico publicado en 1999

Immunological analysis of G-protein expression in the endocrine pancreas.

artículo científico publicado en 1997

Immunological characterization of the guanine-nucleotide binding proteins Gi and Go in rat islets of Langerhans

artículo científico publicado el 1 de abril de 1992

Immunopathology of the human pancreas in type-I diabetes

scientific article published on 28 April 2010

Immunoprecipitation of a pertussis toxin substrate of the Go family from rat islets of Langerhans

artículo científico publicado en 1992

Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets

artículo científico publicado en 2013

Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway

artículo científico publicado en 2013

Insulin Secretagogues with an Imidazoline Structure Inhibit Arginine-Induced Glucagon Secretion from Isolated Rat Islets of Langerhans

artículo científico publicado en 1997

Intracellular events responsible for the inhibition of insulin secretion by somatostatin

scientific article published on 01 December 1989

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

artículo científico publicado en 2019

Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells

artículo científico publicado en 2004

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

artículo científico publicado en 2016

Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus

artículo científico publicado en 2001

Islet inflammation in human type 1 diabetes mellitus

artículo científico publicado en 2014

Islet-associated macrophages in type 2 diabetes.

artículo científico publicado en 2009

Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes

artículo científico publicado en 2006

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

scientific article published on 23 April 2019

Life and death decisions of the pancreatic beta-cell: the role of fatty acids

artículo científico publicado en 2007

Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128 ⬇️

artículo científico publicado el 15 de mayo de 1991

Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells

artículo científico publicado en 2007

Methods for the study of NO-induced apoptosis in cultured cells

artículo científico publicado en 1998

Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP

scientific article published on 01 April 1983

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

artículo científico publicado en 2018

Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

artículo científico publicado en 2004

Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets.

artículo científico publicado en 1999

Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

article

Pancreatic beta-cells express an imidazoline binding site that is distinct from I1 and I2 sites

scientific article published on 01 July 1995

Pancreatic pathology in type 1 diabetes mellitus

artículo científico

Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells

artículo científico publicado en 2011

Phospholipase A2 expression in human and rodent insulin-secreting cells.

artículo científico publicado en 1995

Phosphorylcholine-containing polymers for use in cell encapsulation

artículo científico publicado en 2004

Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism

artículo científico publicado en 1984

Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines.

artículo científico publicado en 2007

Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK.

artículo científico publicado en 2010

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes

scientific article published on 23 January 2019

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

artículo científico publicado en 2017

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis

artículo científico publicado en 2010

Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?

artículo científico publicado en 2024

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells

artículo científico publicado en 2016

Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process

artículo científico publicado en 2006

Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat.

artículo científico publicado en 1991

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

scientific article published on 05 April 2017

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

artículo científico publicado en 2016

Stimulation of hepatic glycogenolysis by alpha 1- and beta 2-adrenergic agonists. Evidence against short term agonist-induced desensitization of the responses

artículo científico publicado en 1982

Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels

artículo científico publicado en 1990

Stimulation of insulin secretion by the imidazoline α2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site

artículo científico publicado en 1993

Stimulation of insulin secretion from isolated rat islets of Langerhans by melittin

article

Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11

artículo científico publicado en 2008

Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells

artículo científico publicado en 2011

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

scientific article published on 15 March 2020

Studies on the interaction of staphylococcal delta-haemolysin with isolated islets of Langerhans.

artículo científico publicado en 1982

Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans

article

Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin

artículo científico publicado en 1983

Subcellular Distribution of Protein Kinase Activities in Mammalian Islets of Langerhans ⬇️

artículo científico publicado el 1 de octubre de 1979

Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms

artículo científico publicado en 1997

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

artículo científico publicado en 2016

The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120.

artículo científico publicado en 2014

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells

artículo científico publicado en 2008

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.

artículo científico publicado en 2012

The diagnosis of insulitis in human type 1 diabetes.

artículo científico publicado en 2013

The effect of staphylococcal ?-haemolysin on the secretory activity of the pancreatic ?-cell

artículo científico publicado en 1981

The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans

artículo científico publicado en 1995

The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites.

artículo científico publicado en 1994

The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines

artículo científico publicado en 2009

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.

artículo científico publicado en 2009

The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway

artículo científico publicado en 2008

The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells

artículo científico publicado en 2004

The significance of GPR119 agonists as a future treatment for type 2 diabetes

artículo científico publicado en 2010

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor

artículo científico publicado en 2015

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

artículo científico publicado en 2018

The α2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells

artículo científico publicado en 1991

Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis

scientific article published on 01 October 1994

Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection

scientific article published on 15 September 2020

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

artículo científico publicado en 2018

Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell

scientific article published on 04 March 2010

Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue

artículo científico publicado en 2010

σ Receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets ⬇️

artículo científico publicado el 5 de junio de 1998

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