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Lista de obras de Roger Cox

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

artículo científico publicado en 2007

A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways

scientific article published on 01 December 2018

A gene-driven ENU-based approach to generating an allelic series in any gene

artículo científico publicado en 2004

A gene-driven approach to the identification of ENU mutants in the mouse

artículo científico publicado en 2002

A high-throughput assay for modulators of NNT activity in permeabilized yeast cells

artículo científico publicado en 2011

A kinetic core model of the glucose-stimulated insulin secretion network of pancreatic beta cells

artículo científico publicado en 2007

A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human

artículo científico publicado en 2006

A missense mutation in the non-neural G-protein alpha-subunit isoforms modulates susceptibility to obesity.

artículo científico publicado en 2009

A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress

artículo científico publicado en 2017

A mouse model for osseous heteroplasia

artículo científico publicado en 2012

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to aCol2a1mutation

article

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

artículo científico publicado en 2009

A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation

artículo científico publicado en 2012

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis

artículo científico publicado en 2012

A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse ⬇️

artículo científico publicado el 8 de agosto de 2010

A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene

artículo científico publicado en 2004

A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes

scientific article published on 23 January 2020

A radiation hybrid transcript map of the mouse genome

artículo científico publicado en 2001

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

artículo científico publicado en 2013

An -Ethyl--Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion

article published in 2018

An N-ethyl-N-nitrosourea (ENU)-induced Tyr265Stop mutation of the DNA polymerase accessory subunit gamma 2 (Polg2) is associated with renal calcification in mice

artículo científico publicado en 2018

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

artículo científico publicado en 2013

Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European Populations: Strongest Evidence for Association With a Variant in the Promoter Region of the Adiponectin Gene

article

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

artículo científico publicado en 2015

Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides

artículo científico publicado en 2002

Association between Angiotensin-Converting Enzyme Gene Polymorphisms and Diabetic Nephropathy: Case-Control, Haplotype, and Family-Based Study in Three European Populations

article

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5

artículo científico publicado en 2013

Bone matrix development in steroid-induced osteoporosis is associated with a consistently reduced fibrillar stiffness linked to altered bone mineral quality

article

Changes in gene expression associated with FTO overexpression in mice

artículo científico publicado en 2014

Chromosomal Mapping of Genetic Loci Controlling Absence Epilepsy Phenotypes in the WAG/Rij Rat

scientific article published on 01 August 2004

Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.

artículo científico publicado en 2017

Commentary: FTO obesity variant circuitry and adipocyte browning in humans

artículo científico publicado en 2015

Comparison of fluorescent single-strand conformation polymorphism analysis and denaturing high-performance liquid chromatography for detection of EXT1 and EXT2 mutations in hereditary multiple exostoses

article

Comprehensive Energy Balance Measurements in Mice

artículo científico publicado en 2016

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice

artículo científico publicado en 2006

Dietary cystine level affects metabolic rate and glycaemic control in adult mice

artículo científico publicado en 2011

Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis

artículo científico publicado en 2013

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

artículo científico publicado en 2017

ENU mutagenesis in the mouse: application to human genetic disease

artículo científico publicado en 2002

ENU mutagenesis, a way forward to understand gene function

artículo científico publicado en 2008

Establishing normal plasma and 24-hour urinary biochemistry ranges in C3H, BALB/c and C57BL/6J mice following acclimatization in metabolic cages

artículo científico publicado en 2010

European rational approach for the genetics of diabetic complications--EURAGEDIC: patient populations and strategy

artículo científico publicado en 2008

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.

artículo científico publicado en 2016

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes

artículo científico publicado en 2008

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice

artículo científico publicado en 2017

FTO influences adipogenesis by regulating mitotic clonal expansion

artículo científico publicado en 2015

FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting

artículo científico publicado en 2011

From mice to humans

artículo científico

Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus

artículo científico publicado en 2009

Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype

scientific journal article

Gene Dosage Effects at the Imprinted Gnas Cluster

artículo científico publicado en 2013

Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk

artículo científico publicado en 2011

Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

artículo científico publicado en 2017

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes

artículo científico publicado en 2016

Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development

artículo científico publicado en 2012

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion

artículo científico publicado en 2016

Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase

artículo científico publicado en 2009

Introduction to mammalian genome special issue: metabolism

artículo científico publicado en 2014

Islet Insulin Secretion Measurements in the Mouse

scientific article published on 01 September 2016

Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family

artículo científico publicado en 1998

Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies

artículo científico publicado en 2014

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

artículo científico publicado en 2015

Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae

artículo científico publicado en 2009

Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway

artículo científico publicado en 2016

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

article

Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study

scientific article published on 11 December 2019

Mouse Models of Human GWAS Hits for Obesity and Diabetes in the Post Genomic Era: Time for Reevaluation

artículo científico publicado en 2017

Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

artículo científico publicado en 2011

Mouse models and type 2 diabetes: translational opportunities ⬇️

artículo científico publicado el 29 de junio de 2011

Multiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis

artículo científico publicado en 2015

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

artículo científico publicado en 2017

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice

artículo científico publicado en 2013

Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not

scientific article published on 25 March 2020

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

artículo científico publicado en 2015

N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice.

artículo científico publicado en 2017

New semidominant mutations that affect mouse development

scientific journal article

Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses

artículo científico publicado en 2012

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

artículo científico publicado en 2016

Novel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis

artículo científico publicado en 2014

Novel phenotypes identified by plasma biochemical screening in the mouse

artículo científico publicado en 2002

On the evolutionary origins of obesity: a new hypothesis

artículo científico publicado en 2014

Overexpression of Fto leads to increased food intake and results in obesity

artículo científico publicado en 2010

Pharmacological inhibition of FTO.

artículo científico publicado en 2015

Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue

artículo científico publicado en 2009

Polygenic Control of Idiopathic Generalized Epilepsy Phenotypes in the Genetic Absence Rats from Strasbourg (GAERS)

artículo científico publicado en 2004

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

artículo científico publicado en 2003

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion

scientific journal article

Refined linkage disequilibrium and physical mapping of the gene locus for X-linked dystonia-parkinsonism (DYT3).

artículo científico publicado en 1999

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

artículo científico publicado en 2018

Rodent models of genetic disease

artículo científico publicado en 2003

Role for the obesity-related FTO gene in the cellular sensing of amino acids

artículo científico publicado en 2013

Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance

scientific journal article

SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models.

artículo científico publicado en 2005

Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging

artículo científico publicado en 2012

Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone.

artículo científico publicado en 2012

The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).

artículo científico publicado en 2015

The Collaborative Cross, a community resource for the genetic analysis of complex traits

article

The European dimension for the mouse genome mutagenesis program

artículo científico publicado en 2004

The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity

artículo científico publicado en 2014

Type-2 diabetes: a cocktail of genetic discovery.

artículo científico publicado en 2006

UKPDS 31: Hepatocyte nuclear factor-1alpha (the MODY3 gene) mutations in late onset Type II diabetic patients in the United Kingdom

article

Use of mouse models in studying type 2 diabetes mellitus

artículo científico publicado en 2011

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