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Lista de obras de Ira Pastan

A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity

artículo científico publicado el 6 de noviembre de 2012

A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake

artículo científico publicado en 2010

A model for obesity and gigantism due to disruption of the Ankrd26 gene

scientific journal article

A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene

artículo científico publicado en 2013

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice

artículo científico publicado en 2014

A novel high-affinity human monoclonal antibody to mesothelin.

artículo científico publicado en 2011

A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity

artículo científico publicado en 2009

A primate-specific POTE-actin fusion protein plays a role in apoptosis

artículo científico publicado en 2009

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

artículo científico publicado en 2011

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

artículo científico publicado en 2010

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells

artículo científico publicado en 2012

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo

artículo científico publicado en 2007

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

artículo científico publicado en 2008

An improved recombinant Fab-immunotoxin targeting CD22 expressing malignancies

artículo científico publicado en 2014

Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts

scientific journal article

Anoctamin and transmembrane channel-like proteins are evolutionarily related.

scientific article published on July 2009

Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models

scientific article published on 19 February 2019

Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial

artículo científico publicado en 2010

Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox

artículo científico publicado el 15 de octubre de 2011

BL22 and lymphoid malignancies

artículo científico publicado en 2006

Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice

artículo científico publicado en 2015

Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy

artículo científico publicado en 2005

Characterization of CD22 expression in acute lymphoblastic leukemia

artículo científico publicado en 2015

Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

artículo científico publicado en 2016

Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers

artículo científico publicado en 2002

Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter

artículo científico publicado en 2003

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

artículo científico publicado en 2016

Class II human leucocyte antigen DRB1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome

artículo científico publicado en 2014

Cloning, molecular characterization, and expression analysis of Copine 8.

artículo científico publicado en 2003

Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity

artículo científico publicado en 2017

Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma

artículo científico publicado en 2017

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

artículo científico publicado en 2019

Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer

artículo científico publicado en 2006

Development of Recombinant Immunotoxins for Hairy Cell Leukemia

artículo científico publicado en 2020

Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins

artículo científico publicado en 2003

Display and selection of scFv antibodies on HEK-293T cells

artículo científico publicado en 2009

Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia.

artículo científico publicado en 2018

Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

scientific article published on 04 May 2016

Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model

artículo científico publicado en 2014

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

artículo científico publicado en 2015

Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti-PD-1 antibody in patients with mesothelioma and mouse tumor models

artículo científico publicado en 2020

Evolution and expression of chimeric POTE-actin genes in the human genome

artículo científico publicado en 2006

Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient's Bedside to Evaluation in Preclinical Models

artículo científico publicado en 2019

Expression of POTE protein in human testis detected by novel monoclonal antibodies

artículo científico publicado en 2007

Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases

scholarly article

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths

artículo científico publicado en 2004

HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.

artículo científico publicado en 2005

High expression of a cytokeratin-associated protein in many cancers

artículo científico publicado en 2006

High-density Functional Display of Proteins on Bacteriophage Lambda

artículo científico publicado el 21 de noviembre de 2003

Identification and characterization of fully human anti-CD22 monoclonal antibodies

artículo científico publicado en 2009

Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.

artículo científico publicado en 2013

Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia

artículo científico

Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).

artículo científico publicado en 2007

Immunobiological treatments of hairy-cell leukaemia

artículo científico publicado en 2003

Immunoconjugates in the management of hairy cell leukemia

artículo científico publicado en 2015

Immunogenicity of therapeutic recombinant immunotoxins

artículo científico publicado en 2016

Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies

artículo científico publicado en 2005

Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

artículo científico publicado en 2020

Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs

artículo científico publicado en 2010

Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

artículo científico publicado el 16 de abril de 2012

Immunotoxin treatment of cancer

artículo científico publicado en 2007

Immunotoxins in the treatment of hematologic malignancies

artículo científico publicado en 2006

Immunotoxins in the treatment of refractory hairy cell leukemia

artículo científico publicado en 2006

Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.

artículo científico publicado en 2002

Improving the in vivo efficacy of an anti-Tac (CD25) immunotoxin by Pseudomonas exotoxin A domain II engineering

artículo científico publicado en 2018

In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma

artículo científico publicado en 2004

In vitro antibody affinity maturation targeting germline hotspots

artículo científico publicado en 2009

In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin

artículo científico publicado en 2004

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning

artículo científico publicado en 2007

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors

artículo científico publicado en 2008

Isolation of anti-CD22 Fv with high affinity by Fv display on human cells

artículo científico publicado en 2006

Lipoprotein modulation of proteinuric renal injury

scientific article published on 24 April 2019

Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor

artículo científico publicado en 2015

Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin.

artículo científico publicado en 2018

MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer

artículo científico publicado en 2002

Mammalian cell display for antibody engineering

artículo científico publicado en 2009

Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy

artículo científico publicado en 2020

Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice

artículo científico publicado en 2014

Mesothelin expression in human lung cancer

artículo científico publicado en 2007

Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats

artículo científico publicado en 2009

Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells

artículo científico publicado en 2007

Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

artículo científico publicado en 2006

Mesothelin: a new target for immunotherapy

artículo científico publicado en 2004

Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.

artículo científico publicado en 2013

Multiple proteases are involved in mesothelin shedding by cancer cells

artículo científico publicado en 2020

Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules

artículo científico publicado en 2003

NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate

artículo científico publicado en 2004

NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.

artículo científico publicado en 2007

New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy

artículo científico publicado en 2009

New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma

artículo científico publicado en 2015

New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.

artículo científico publicado en 2005

Non-AUG translational initiation of a short CAPC transcript generating protein isoform

artículo científico publicado en 2009

Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments

artículo científico publicado en 2002

PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity

artículo científico publicado en 2008

PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach

artículo científico publicado en 2002

POTE paralogs are induced and differentially expressed in many cancers.

artículo científico publicado en 2006

POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells

artículo científico publicado el 3 de enero de 2012

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer

artículo científico publicado en 2002

PRAC2: A new gene expressed in human prostate and prostate cancer

artículo científico publicado el 1 de julio de 2003

Palmitoylation of POTE family proteins for plasma membrane targeting

artículo científico publicado en 2007

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts

artículo científico publicado el 26 de abril de 2011

Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia

artículo científico publicado en 2012

Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.

artículo científico publicado en 2015

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits

artículo científico publicado en 2019

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig

artículo científico publicado en 2003

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.

scientific article published on 25 July 2016

Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells

artículo científico publicado en 2008

Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors

artículo científico publicado en 2012

Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38.

artículo científico publicado en 2017

Recognition of Mesothelin by the Therapeutic Antibody MORAb-009: STRUCTURAL AND MECHANISTIC INSIGHTS

artículo científico publicado en 2012

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.

artículo científico publicado en 2011

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

artículo científico publicado en 2012

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

artículo científico publicado en 2014

Recombinant immunotoxins for treating cancer

artículo científico publicado en 2004

Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

artículo científico publicado en 2016

Removing T-cell epitopes with computational protein design.

artículo científico publicado en 2014

SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors

scholarly article by Yasmin Leshem et al published 14 November 2018 in Toxins

Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera

artículo científico publicado en 2006

Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.

artículo científico publicado en 2008

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers

artículo científico publicado el 1 de abril de 2012

Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity

scientific article published on 23 December 2019

Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study

artículo científico publicado en 2005

Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy.

artículo científico publicado en 2011

TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates

scientific journal article

TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma.

artículo científico publicado en 2005

Targeted cytotoxic therapy kills persisting HIV infected cells during ART

artículo científico publicado en 2014

Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin

artículo científico publicado en 2002

Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies

artículo científico publicado en 2008

The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein

artículo científico publicado en 2005

The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria

artículo científico publicado en 2004

The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion.

artículo científico publicado en 2011

The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan

artículo científico publicado en 2011

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.

artículo científico publicado en 2014

Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level

artículo científico publicado en 2008

Toxin-Based Targeted Therapy for Malignant Brain Tumors

artículo científico publicado el 9 de febrero de 2012

Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates

artículo científico publicado el 15 de octubre de 2011