Lista de obras - Lei Shi - Dominio Público Uruguay

A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter

scientific article published on 22 August 2019

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

artículo científico publicado en 2019

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

scientific article published on 31 July 2006

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

artículo científico publicado en 2008

A new era of rationally designed antipsychotics.

artículo científico publicado en 2018

A new mechanism of allostery in a G protein-coupled receptor dimer

artículo científico publicado en 2014

A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding.

artículo científico publicado en 2005

A role for information collection, management, and integration in structure-function studies of G-protein coupled receptors.

artículo científico publicado en 2006

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

artículo científico publicado en 2013

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

scientific article published on 04 February 2020

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

artículo científico publicado en 2008

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

article published in the Proceedings of the National Academy of Sciences of the United States of America

Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design

artículo científico publicado en 2014

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

artículo científico publicado en 2009

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

artículo científico publicado en 2016

Building a protein name dictionary from full text: a machine learning term extraction approach

artículo científico publicado en 2005

Chloride binding site of neurotransmitter sodium symporters

artículo científico publicado en 2013

Computational Modeling of C-Terminal Tails to Predict the Calcium-Dependent Secretion of Endoplasmic Reticulum Resident Proteins

artículo científico publicado en 2021

Computational approaches to detect allosteric pathways in transmembrane molecular machines

artículo científico publicado en 2016

Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.

artículo científico publicado en 2015

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290

artículo científico publicado en 2016

Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

artículo científico publicado en 2014

Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms

artículo científico publicado en 2010

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

artículo científico publicado en 2005

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor

artículo científico publicado en 2014

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand

artículo científico publicado en 2015

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

artículo científico publicado en 2020

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues

artículo científico publicado en 2014

Experimental conditions can obscure the second high-affinity site in LeuT.

artículo científico publicado en 2012

Exploring Substrate Binding in the Extracellular Vestibule of MhsT by Atomistic Simulations and Markov Models.

artículo científico publicado en 2018

Functional studies of the T295M mutation causing Glut1 deficiency: glucose efflux preferentially affected by T295M.

artículo científico publicado en 2008

Grafted biomembranes containing membrane proteins--the case of the leucine transporter

artículo científico publicado en 2015

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.

artículo científico publicado en 2018

High-potency ligands for DREADD imaging and activation in rodents and monkeys

scientific article published on 11 October 2019

Identification of a putative binding site critical for general anesthetic activation of TRPA1.

artículo científico publicado en 2017

Identification of a second substrate-binding site in solute-sodium symporters

artículo científico publicado en 2015

Identification of a second substrate-binding site in solute-sodium symporters.

artículo científico publicado en 2014

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

artículo científico publicado en 2021

Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.

artículo científico publicado en 2016

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

artículo científico publicado en 2010

K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA).

artículo científico publicado en 2014

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

artículo científico publicado en 2015

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

artículo científico publicado en 2014

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

artículo científico publicado en 2012

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

artículo científico publicado en 2016

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism

artículo científico publicado en 2017

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.

artículo científico publicado en 2018

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

artículo científico publicado en 2010

Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus

artículo científico publicado en 2015

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum.

artículo científico publicado en 2006

Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors

artículo científico publicado en 2015

Structural effects of quinacrine binding in the open channel of the acetylcholine receptor.

artículo científico publicado en 2003

Structural signatures and membrane helix 4 in GLUT1: inferences from human blood-brain glucose transport mutants

artículo científico publicado en 2008

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

artículo científico publicado en 2017

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

artículo científico publicado en 2009

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

artículo científico publicado en 2015

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).

artículo científico publicado en 2017

Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.

scientific article published on 02 October 2013

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

artículo científico publicado en 2018

The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation.

artículo científico publicado en 2017

The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.

artículo científico publicado en 2018

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

artículo científico publicado en 2018

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

artículo científico publicado en 2010

The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT.

artículo científico publicado en 2013

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

artículo científico publicado en 2002

The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle

scientific journal article

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

artículo científico publicado en 2020

The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.

artículo científico publicado en 2017

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride

artículo científico publicado en 2014

The sodium/multivitamin transporter: a multipotent system with therapeutic implications.

artículo científico

The sodium/proline transporter PutP of Helicobacter pylori.

artículo científico publicado en 2013

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

artículo científico publicado en 2018

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor

artículo científico publicado en 2016

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.

scientific article published on 28 September 2016

Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors.

artículo científico publicado en 2002

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

artículo científico publicado en 2015

Lista de obras de Lei Shi

A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

A new era of rationally designed antipsychotics.

A new mechanism of allostery in a G protein-coupled receptor dimer

A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding.

A role for information collection, management, and integration in structure-function studies of G-protein coupled receptors.

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

Building a protein name dictionary from full text: a machine learning term extraction approach

Chloride binding site of neurotransmitter sodium symporters

Computational Modeling of C-Terminal Tails to Predict the Calcium-Dependent Secretion of Endoplasmic Reticulum Resident Proteins

Computational approaches to detect allosteric pathways in transmembrane molecular machines

Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290

Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues

Experimental conditions can obscure the second high-affinity site in LeuT.

Exploring Substrate Binding in the Extracellular Vestibule of MhsT by Atomistic Simulations and Markov Models.

Functional studies of the T295M mutation causing Glut1 deficiency: glucose efflux preferentially affected by T295M.

Grafted biomembranes containing membrane proteins--the case of the leucine transporter

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.

High-potency ligands for DREADD imaging and activation in rodents and monkeys

Identification of a putative binding site critical for general anesthetic activation of TRPA1.

Identification of a second substrate-binding site in solute-sodium symporters

Identification of a second substrate-binding site in solute-sodium symporters.

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA).

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum.

Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors

Structural effects of quinacrine binding in the open channel of the acetylcholine receptor.

Structural signatures and membrane helix 4 in GLUT1: inferences from human blood-brain glucose transport mutants

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).

Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation.

The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT.

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride

The sodium/multivitamin transporter: a multipotent system with therapeutic implications.

The sodium/proline transporter PutP of Helicobacter pylori.

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.

Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors.

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?