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Lista de obras de Jonathan Kimmelman

A canadian perspective on ethics review and neuroimaging: tensions and solutions.

artículo científico publicado en 2011

A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib

artículo científico publicado en 2015

A systematic review and meta-analysis of pregabalin preclinical studies

scientific article published on 01 April 2020

A theoretical framework for early human studies: uncertainty, intervention ensembles, and boundaries

artículo científico

Accelerated Drug Approval and Health Inequality

article

Accessibility of trial reports for drugs stalling in development: a systematic assessment of registered trials

artículo científico publicado en 2015

Against pandemic research exceptionalism

artículo científico publicado en 2020

Analysis of consent validity for invasive, nondiagnostic research procedures

scientific article published on 01 September 2012

Are outcome-adaptive allocation trials ethical?

artículo científico publicado en 2015

Are phase 1 trials therapeutic? Risk, ethics, and division of labor

artículo científico publicado en 2012

Assessing risk/benefit for trials using preclinical evidence: a proposal

artículo científico publicado en 2015

Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies

scientific article published on 21 May 2019

Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review

artículo científico publicado en 2019

Battling a thousand points of might.

artículo científico publicado en 2009

Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib

artículo científico publicado en 2015

Benefit, burden, and impact for a cohort of post-approval cancer combination trials

artículo científico publicado en 2019

Better to be in The Placebo Arm for Trials of Neurological Therapies?

artículo científico publicado en 2018

Beyond human subjects: risk, ethics, and clinical development of nanomedicines

artículo científico publicado en 2012

Burdensome Research Procedures in Trials: Why Less Is More

artículo científico publicado en 2017

Can Oncologists Predict the Efficacy of Treatments in Randomized Trials?

scientific article published on 27 July 2020

Can cancer researchers accurately judge whether preclinical reports will reproduce?

artículo científico publicado en 2017

Can patient decision aids help people make good decisions about participating in clinical trials? A study protocol

artículo científico publicado en 2008

Cheap shots and pricey propositions: evidence, disclosure, and treatment of age-related macular degeneration

artículo científico publicado en 2007

Clinical Trial Portfolios: A Critical Oversight in Human Research Ethics, Drug Regulation, and Policy

scientific article published on 01 July 2019

Clinical Trials in Medical Center Advertising

Clinical development success rates and social value of pediatric Phase 1 trials in oncology

artículo científico publicado en 2020

Clinical trials and SCID row: the ethics of phase 1 trials in the developing world

artículo científico publicado en 2007

Comparison between protocols and publications for prognostic and predictive cancer biomarker studies

artículo científico publicado en 2019

Completeness of clinical evidence citation in trial protocols: A cross-sectional analysis

artículo científico publicado en 2022

Consent for nondiagnostic research biopsies: a pilot study of participant recall and therapeutic orientation

artículo científico publicado en 2014

Consider drug efficacy before first-in-human trials

artículo científico publicado en 2017

Decision analysis approach to risk/benefit evaluation in the ethical review of controlled human infection studies

artículo científico publicado en 2020

Design and Reporting of Targeted Anticancer Preclinical Studies: A Meta-Analysis of Animal Studies Investigating Sorafenib Antitumor Efficacy

artículo científico publicado en 2016

Distinguishing between exploratory and confirmatory preclinical research will improve translation

artículo científico publicado en 2014

Do We Know Whether Researchers and Reviewers are Estimating Risk and Benefit Accurately?

artículo científico publicado en 2016

Drug Development at the Portfolio Level Is Important for Policy, Care Decisions and Human Protections

artículo científico publicado en 2017

Elements of informed consent and decision quality were poorly correlated in informed consent documents

artículo científico

Elements of style: consent form language and the therapeutic misconception in phase 1 gene transfer trials

artículo científico publicado en 2005

Ethical Review and Methodologic Innovation in Phase 1 Cancer Trials-Reply

artículo científico publicado en 2019

Ethical and Policy Issues for Seamless Phase I Oncology Trials

artículo científico publicado en 2019

Ethical and policy issues in the clinical translation of stem cells: report of a focus session at the ISSCR Tenth Annual Meeting

artículo científico publicado en 2012

Ethical considerations of e-cigarette use for tobacco harm reduction

artículo científico publicado en 2016

Ethical development of stem-cell-based interventions

scientific article published on 03 July 2019

Ethical issues in the development of oncology drugs

artículo científico publicado en 2018

Ethics at phase 0: clarifying the issues

artículo científico publicado en 2007

Ethics of Cancer Gene Transfer Clinical Research

article

Ethics of cancer gene transfer clinical research

artículo científico publicado en 2009

Ethics of controlled human infection to study COVID-19

scientific article published on 07 May 2020

Ethics, ambiguity aversion, and the review of complex translational clinical trials

artículo científico publicado en 2011

Ethics, error, and initial trials of efficacy

artículo científico publicado en 2013

Evaluation of Journal Registration Policies and Prospective Registration of Randomized Clinical Trials of Nonregulated Health Care Interventions

artículo científico publicado en 2019

Extending clinical equipoise to phase 1 trials involving patients: unresolved problems

artículo científico publicado en 2010

Faithful companions: a proposal for neurooncology trials in pet dogs

artículo científico publicado en 2007

Forecasts for the Attainment of Major Research Milestones in Parkinson's Disease

scientific article published on 24 April 2020

Group sample sizes in nonregulated health care intervention trials described as randomized controlled trials were overly similar

scientific article published on 19 December 2019

Harms From Uninformative Clinical Trials

artículo científico publicado en 2019

Helsinki discords: FDA, ethics, and international drug trials

artículo científico publicado en 2009

How Informative Were Early SARS-CoV-2 Treatment and Prevention Trials? A longitudinal cohort analysis of trials registered on clinicaltrials.gov

artículo científico publicado en 2021

How do researchers decide early clinical trials?

artículo científico publicado en 2016

How well are Phase 2 cancer trial publications supported by preclinical efficacy evidence?

scientific article published on 29 May 2019

Imatinib and the long tail of targeted drug development

artículo científico publicado en 2020

Impact of Precision Medicine on Efficiencies of Novel Drug Development in Cancer

scientific article published on 13 November 2019

Increasing efficiency of preclinical research by group sequential designs

artículo científico publicado en 2017

Increasing placebo responses over time in U.S. clinical trials of neuropathic pain

artículo científico publicado en 2015

Inefficiencies and Patient Burdens in the Development of the Targeted Cancer Drug Sorafenib: A Systematic Review

artículo científico publicado en 2017

Informed consent documents do not encourage good-quality decision making

artículo científico publicado en 2012

Inventors as investigators: the ethics of patents in clinical trials

artículo científico publicado en 2007

Is Participation in Cancer Phase I Trials Really Therapeutic?

artículo científico publicado en 2016

Justice in translation: from bench to bedside in the developing world.

artículo científico publicado en 2008

Launching invasive, first-in-human trials against Parkinson's disease: ethical considerations

artículo científico publicado en 2009

Medical research, risk, and bystanders

artículo científico publicado en 2005

Missing the forest: further thoughts on the ethics of bystander risk in medical research.

artículo científico publicado en 2007

New ISSCR guidelines: clinical translation of stem cell research

artículo científico publicado en 2016

Nonpublication of trial results for new neurological drugs: A systematic review.

artículo científico publicado en 2017

Organ donor intervention trials and the ethical challenge of bystander organ recipients

artículo científico publicado en 2019

Participant Protection in Phase 1 Pediatric Cancer Trials

scientific article published on 01 January 2019

Patient burden and clinical advances associated with postapproval monotherapy cancer drug trials: a retrospective cohort study

artículo científico publicado en 2020

Patient-Funded Trials: Opportunity or Liability?

artículo científico

Phase I trials as therapeutic options: (usually) a betrayal of evidence-based medicine

scientific article published on 01 December 2019

Policy: Global standards for stem-cell research

artículo científico publicado en 2016

Position statement on the provision and procurement of human eggs for stem cell research

artículo científico publicado en 2013

Potential harms from legalization of recreational cannabis use in Canada

artículo científico publicado en 2019

Preclinical efficacy in therapeutic area guidelines from the U.S. Food and Drug Administration and the European Medicines Agency: a cross-sectional study

artículo científico publicado en 2018

Preclinical efficacy studies in investigator brochures: Do they enable risk-benefit assessment?

artículo científico publicado en 2018

Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty

artículo científico publicado en 2011

Probability of Success and Timelines for the Development of Vaccines for Emerging and Reemerged Viral Infectious Diseases

artículo científico publicado en 2020

Proportion of Patients in Phase 1 Oncology Trials Receiving Treatments that are Ultimately Approved

scientific article published on 01 April 2020

Protection at the cutting edge: the case for central review of human gene transfer research ⬇️

artículo científico publicado el 14 de octubre de 2003

Publication and reporting conduct for pharmacodynamic analyses of tumor tissue in early-phase oncology trials

artículo científico publicado en 2012

Recent developments in gene transfer: risk and ethics

artículo científico publicado en 2005

Regulating impact on bystanders in clinical trials: An unsettled frontier

artículo científico publicado en 2019

Rejoinder

artículo científico publicado en 2015

Reply to 'Correcting the ASCO position on phase I clinical trials in cancer'

artículo científico publicado en 2020

Research ethics. Beyond access vs. protection in trials of innovative therapies

artículo científico publicado en 2010

Research ethics. Rethinking research ethics: the case of postmarketing trials

artículo científico publicado en 2012

Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis.

artículo científico publicado en 2018

Risk of surgical delivery to deep nuclei: a meta-analysis

artículo científico publicado en 2011

Risks and benefits of unapproved disease-modifying treatments for neurodegenerative disease

scientific article published on 02 December 2019

SCIENTIFIC COMMUNITY. Confronting stem cell hype

artículo científico publicado en 2016

Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines

artículo científico publicado en 2016

Should preclinical studies be registered?

artículo científico publicado en 2012

Stable ethics: enrolling non-treatment-refractory volunteers in novel gene transfer trials

article

Stem cell trials: lessons from gene transfer research

artículo científico publicado en 2006

The Challenges of Validating in Precision Medicine: The Case of Excision Repair Cross-Complement Group 1 Diagnostic Testing

artículo científico publicado en 2016

The Efficacy and Safety of Low Molecular Weight Heparin Administration to Improve Survival of Cancer Patients: A Systematic Review and Meta-Analysis

scientific article published on 05 May 2020

The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months

scientific article published on 27 February 2019

The Research Optimist's Defense

artículo científico publicado en 2016

The attitudes of brain cancer patients and their caregivers towards death and dying: a qualitative study

artículo científico publicado en 2007

The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials.

artículo científico publicado en 2018

The ethics of human gene transfer

artículo científico publicado en 2008

The ethics of managing affective and emotional states to improve informed consent: autonomy, comprehension, and voluntariness

artículo científico publicado el 6 de octubre de 2010

The paradox of precision medicine

artículo científico publicado en 2018

The proportion of North American cancer trials that evaluate novel targets

artículo científico publicado en 2020

The risk-escalation model: a principled design strategy for early-phase trials

artículo científico publicado en 2014

The secret realm of phase I trials in healthy volunteers

artículo científico publicado en 2015

The social function of clinical equipoise

artículo científico publicado en 2012

The stem cell market and policy options: a call for clarity.

artículo científico publicado en 2018

The structure of clinical translation: efficiency, information, and ethics

artículo científico publicado en 2015

The sublime inertia of informed consent language in early phase clinical trials involving patients

scientific article published on 24 November 2020

The therapeutic misconception at 25: treatment, research, and confusion

artículo científico publicado en 2007

There is still a place for significance testing in clinical trials

scientific article published on 09 May 2019

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments

artículo científico publicado en 2013

Tomorrow, interrupted? Risk, ethics, and medical advance in gene transfer

artículo científico publicado en 2009

Towards a global human embryonic stem cell bank: differential termination

artículo científico publicado en 2007

Translational research and the U.S. federal elections.

artículo científico publicado en 2016

Trials that say "maybe": the disconnect between exploratory and confirmatory testing after drug approval

artículo científico publicado en 2018

Unsuccessful trial accrual and human subjects protections: an empirical analysis of recently closed trials.

artículo científico publicado en 2014

Using decision aids may improve informed consent for research

article

Valuing risk: the ethical review of clinical trial safety

artículo científico publicado en 2004

What Research Ethics (Often) Gets Wrong about Minimal Risk

scientific article published on 01 January 2020

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke

artículo científico publicado en 2016

Why IRBs should protect bystanders in human research

scientific article published on 25 September 2020

Why clinical translation cannot succeed without failure

artículo científico publicado en 2015

Wisdom of the expert crowd prediction of response for 3 neurology randomized trials

artículo científico publicado en 2020

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