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A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection.

artículo científico publicado en 2016

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes

artículo científico publicado en 2016

A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule.

artículo científico publicado en 2016

A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane

artículo científico publicado en 2010

A polytherapy based approach to combat antimicrobial resistance using cubosomes

artículo científico publicado en 2022

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

artículo científico publicado en 2013

A simple method for the assay of colistin in human plasma, using pre-column derivatization with 9-fluorenylmethyl chloroformate in solid-phase extraction cartridges and reversed-phase high-performance liquid chromatography.

artículo científico publicado en 2001

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

artículo científico publicado en 2022

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria

artículo científico publicado en 2017

Activities of colistin- and minocycline-based combinations against extensive drug resistant Acinetobacter baumannii isolates from intensive care unit patients. ⬇️

artículo científico publicado en 2011

Activity of colistin against heteroresistant Acinetobacter baumannii and emergence of resistance in an in vitro pharmacokinetic/pharmacodynamic model.

artículo científico publicado en 2007

Activity of colistin combined with doripenem at clinically relevant concentrations against multidrug-resistant Pseudomonas aeruginosa in an in vitro dynamic biofilm model.

artículo científico publicado en 2014

Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic-Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model.

artículo científico publicado en 2017

Agents of Last Resort: Polymyxin Resistance.

artículo científico publicado en 2016

Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa.

artículo científico publicado en 2018

An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI.

artículo científico publicado en 2016

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

artículo científico publicado en 2015

Antibacterial Low Molecular Weight Cationic Polymers: Dissecting the Contribution of Hydrophobicity, Chain Length and Charge to Activity

artículo científico publicado en 2016

Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains

scientific article published on 17 July 2007

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'.

artículo científico publicado en 2017

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria

artículo científico publicado en 2015

Antimicrobial Activity from Colistin-Heparin Lamellar-Phase Complexes for the Coating of Biomedical Devices.

artículo científico publicado en 2016

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics ⬇️

artículo científico publicado el 28 de noviembre de 2011

Atomic force microscopy investigation of the morphology and topography of colistin-heteroresistant Acinetobacter baumannii strains as a function of growth phase and in response to colistin treatment

artículo científico publicado en 2009

Brain penetration of colistin in mice assessed by a novel high-performance liquid chromatographic technique.

artículo científico publicado en 2009

Cell surface hydrophobicity of colistin-susceptible vs resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implications

artículo científico publicado en 2012

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

artículo científico publicado en 2015

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula

artículo científico publicado en 2011

Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa

artículo científico publicado en 2018

Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance

artículo científico publicado en 2016

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance

artículo científico publicado en 2015

Colistin and polymyxin B: peas in a pod, or chalk and cheese?

artículo científico publicado en 2014

Colistin hetero-resistance in multidrug-resistant Acinetobacter baumannii clinical isolates from the Western Pacific region in the SENTRY antimicrobial surveillance programme

artículo científico publicado en 2008

Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa.

artículo científico publicado en 2006

Colistin powders with high aerosolisation efficiency for respiratory infection: preparation and in vitro evaluation

artículo científico publicado en 2013

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

artículo científico publicado en 2010

Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways.

artículo científico publicado en 2014

Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosa

artículo científico publicado en 2011

Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections

artículo científico publicado en 2006

ColistinDose, a Mobile App for Determining Intravenous Dosage Regimens of Colistimethate in Critically Ill Adult Patients: Clinician-Centered Design and Development Study

artículo científico publicado en 2020

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

artículo científico publicado en 2016

Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii

artículo científico publicado en 2016

Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model.

artículo científico publicado en 2008

Comparison of the composition and in vitro activity of polymyxin B products

artículo científico publicado en 2018

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation

scientific article published on 03 July 2018

Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice

artículo científico publicado en 2018

Correction: ColistinDose, a Mobile App for Determining Intravenous Dosage Regimens of Colistimethate in Critically Ill Adult Patients: Clinician-Centered Design and Development Study

artículo científico publicado en 2020

Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages

artículo científico publicado en 2022

Design and Evaluation of Novel Polymyxin Fluorescent Probes

artículo científico publicado en 2017

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

artículo científico publicado en 2010

Development and validation of a liquid chromatography-mass spectrometry assay for polymyxin B in bacterial growth media.

artículo científico publicado en 2014

Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

artículo científico publicado en 2010

Discovery of -Mediated Colistin Resistance in a Highly Virulent Escherichia coli Lineage

artículo científico publicado en 2018

Dosing guidance for intravenous colistin in critically-ill patients

artículo científico publicado en 2016

Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology.

artículo científico publicado en 2012

Effect of Systemic Infection Induced by Pseudomonas aeruginosa on the Brain Uptake of Colistin in Mice ⬇️

artículo científico publicado el 30 de julio de 2012

Effect of colistin exposure and growth phase on the surface properties of live Acinetobacter baumannii cells examined by atomic force microscopy

artículo científico publicado en 2011

Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa

artículo científico publicado en 2013

Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin

artículo científico publicado en 2015

Effects of colistin on the sensory nerve conduction velocity and F-wave in mice

artículo científico publicado en 2014

Efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens: A proof-of-concept study.

artículo científico publicado en 2018

Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model

artículo científico publicado en 2017

Emergence of High-Level Colistin Resistance in an Acinetobacter baumannii Clinical Isolate Mediated by Inactivation of the Global Regulator H-NS

artículo científico publicado en 2018

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators

artículo científico publicado en 2015

Extracorporeal clearance of colistin methanesulphonate and formed colistin in end-stage renal disease patients receiving intermittent haemodialysis: implications for dosing

artículo científico publicado en 2015

Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae

scientific article published on 01 June 2018

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus

artículo científico publicado en 2014

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "Superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators.

artículo científico publicado en 2016

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.

artículo científico publicado en 2017

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity

artículo científico publicado en 2017

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa.

artículo científico publicado en 2018

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

artículo científico publicado en 2016

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

artículo científico publicado en 2017

High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii

artículo científico publicado en 2016

How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder?

artículo científico publicado en 2016

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

artículo científico publicado en 2015

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

artículo científico publicado en 2017

Imaging the distribution of polymyxins in the kidney

artículo científico publicado en 2014

Improved Physical Stability and Aerosolization of Inhalable Amorphous Ciprofloxacin Powder Formulations by Incorporating Synergistic Colistin

scientific article published on 03 August 2018

In situprobing the interior of single bacterial cells at nanometer scale

artículo científico publicado en 2014

In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

artículo científico publicado en 2001

In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae

artículo científico publicado en 2008

Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.

artículo científico publicado en 2011

Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation.

artículo científico publicado en 2012

International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of Americ

scientific article published on 01 January 2019

Intracellular localization of polymyxins in human alveolar epithelial cells

article

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

artículo científico publicado en 2017

Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization

artículo científico publicado en 2016

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity

artículo científico publicado en 2022

LC-MS/MS determination of colistin in Mueller-Hinton broth for in vitro pharmacodynamic studies.

artículo científico publicado en 2014

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Clinical Isolates

artículo científico publicado en 2018

Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37.

artículo científico publicado en 2012

Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway.

artículo científico publicado en 2014

Major pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells

artículo científico publicado en 2015

Mechanism-based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model.

artículo científico publicado en 2017

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR

scholarly article by Maytham Hussein et al published 2018 in Computational and Structural Biotechnology Journal

Melatonin attenuates colistin-induced nephrotoxicity in rats.

artículo científico publicado en 2011

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant

artículo científico publicado en 2018

Metabolic Responses to Polymyxin Treatment in ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling

article

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress.

artículo científico publicado en 2017

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.

artículo científico publicado en 2012

Nanoscale focused ion beam tomography of single bacterial cells for assessment of antibiotic effects

artículo científico publicado en 2014

Near-Atomic Three-Dimensional Mapping for Site-Specific Chemistry of 'Superbugs'.

artículo científico publicado en 2016

New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae.

artículo científico publicado en 2017

New dosing strategies for an old antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease

artículo científico publicado en 2013

New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection.

artículo científico publicado en 2015

Novel Inhaled Combination Powder Containing Amorphous Colistin and Crystalline Rifapentine with Enhanced Antimicrobial Activities against Planktonic Cells and Biofilm of Pseudomonas aeruginosa for Respiratory Infections

artículo científico publicado en 2014

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens

artículo científico publicado en 2018

Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae

artículo científico publicado en 2019

Novel rate-area-shape modeling approach to quantify bacterial killing and regrowth for in vitro static time-kill studies

artículo científico publicado en 2014

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa

artículo científico publicado en 2016

Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria

artículo científico publicado en 2015

Optimizing use of colistin and polymyxin B in the critically ill.

artículo científico publicado en 2007

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

scientific article published on 11 April 2016

Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm.

artículo científico publicado en 2018

Pharmacodynamics of colistin and fosfomycin: a 'treasure trove' combination combats KPC-producing Klebsiella pneumoniae

artículo científico publicado en 2017

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli

artículo científico publicado en 2017

Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model

artículo científico publicado en 2010

Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically ill patients

artículo científico publicado en 2017

Pharmacokinetics and pharmacodynamics of 'old' polymyxins: what is new?

artículo científico publicado en 2012

Pharmacokinetics and time-kill of inhaled antipseudomonal bacteriophage therapy in mice

artículo científico publicado en 2020

Pharmacokinetics of colistin methanesulfonate (CMS) in healthy chinese subjects after single and multiple intravenous doses

artículo científico publicado en 2018

Pharmacokinetics of colistin methanesulfonate and formed colistin in end-stage renal disease patients receiving continuous ambulatory peritoneal dialysis

artículo científico publicado en 2013

Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate.

artículo científico publicado en 2004

Pharmacokinetics of intravenous polymyxin B in critically ill patients.

artículo científico publicado en 2008

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

artículo científico publicado en 2009

Pharmacokinetics of polymyxin B in patients on continuous venovenous haemodialysis ⬇️

artículo científico publicado el 23 de noviembre de 2012

Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.

artículo científico publicado en 2017

Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model

artículo científico publicado en 2016

Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

artículo científico publicado en 2016

Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models

artículo científico publicado en 2017

Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies

artículo científico publicado en 2013

Polymyxin B and Fosfomycin Thwart KPC-producing Klebsiella pneumoniae in the Hollow Fibre Infection Model.

artículo científico publicado en 2018

Polymyxin B causes DNA damage in HK-2 cells and mice.

artículo científico publicado en 2018

Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review.

artículo científico publicado en 2007

Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensive Drug-resistant Pseudomonas aeruginosa.

artículo científico publicado en 2018

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

artículo científico publicado en 2016

Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae: pharmacodynamics and morphological changes.

artículo científico publicado en 2016

Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era.

artículo científico publicado en 2017

Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.

artículo científico publicado en 2016

Polymyxin causes cell envelope remodelling and stress responses in mcr-1-harbouring Escherichia coli

artículo científico publicado en 2022

Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use.

artículo científico publicado en 2015

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.

artículo científico publicado en 2017

Polymyxin-induced cell death of human macrophage-like THP-1 and neutrophil-like HL-60 cells associated with the activation of apoptotic pathways

artículo científico publicado en 2020

Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity

artículo científico publicado en 2017

Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance

artículo científico publicado en 2020

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro.

artículo científico publicado en 2013

Polymyxins for CNS infections: Pharmacology and neurotoxicity

artículo científico publicado en 2017

Polymyxins: a new hope in combating Gram-negative superbugs?

artículo científico publicado en 2016

Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients

artículo científico publicado en 2011

Population pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections.

artículo científico publicado en 2013

Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens.

artículo científico publicado en 2013

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells

artículo científico publicado en 2017

Preliminary clinical study of the effect of ascorbic acid on colistin-associated nephrotoxicity

artículo científico publicado en 2015

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria

artículo científico publicado en 2014

Production of highly stable spray dried phage formulations for treatment of Pseudomonas aeruginosa lung infection.

artículo científico publicado en 2017

Protective effects of ginsenoside Rg1 against colistin sulfate-induced neurotoxicity in PC12 cells.

artículo científico publicado en 2013

Pseudomonas aeruginosa Infection after Pancreatoduodenectomy: Risk Factors and Clinic Impacts

artículo científico publicado en 2015

Pulmonary Pharmacokinetics of Colistin Following Administration of Dry Powder Aerosols in Rats.

artículo científico publicado en 2017

Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: targeting advantage of inhalational administration.

artículo científico publicado en 2014

Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe.

scientific article published on 09 January 2016

Rediscovering the octapeptins.

artículo científico publicado en 2017

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

artículo científico publicado en 2020

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

artículo científico publicado en 2015

Species-Dependent Blood-Brain Barrier Disruption of Lipopolysaccharide: Amelioration by Colistin In Vitro and In Vivo

artículo científico publicado en 2013

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

artículo científico publicado en 2018

Stability of colistin and colistin methanesulfonate in aqueous media and plasma as determined by high-performance liquid chromatography.

artículo científico publicado en 2003

Stability of colistin methanesulfonate in pharmaceutical products and solutions for administration to patients.

artículo científico publicado en 2008

Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae

artículo científico publicado en 2015

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

artículo científico publicado en 2018

Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein

artículo científico publicado en 2012

Substantial Targeting Advantage Achieved by Pulmonary Administration of Colistin Methanesulfonate in a Large-Animal Model.

artículo científico publicado en 2016

Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae.

artículo científico publicado en 2013

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study

artículo científico publicado en 2018

Synergistic activity of colistin and rifampin combination against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacokinetic/pharmacodynamic model

artículo científico publicado en 2013

Synergistic antibiotic combination powders of colistin and rifampicin provide high aerosolization efficiency and moisture protection

artículo científico publicado en 2013

Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol

artículo científico publicado en 2015

Synergistic killing of multidrug-resistant Pseudomonas aeruginosa at multiple inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model

artículo científico publicado en 2011

Teaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'.

artículo científico publicado en 2014

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

artículo científico publicado en 2012

The development and validation of a simple liquid chromatography-tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices

artículo científico publicado en 2017

The impact of backbone N-methylation on the structure-activity relationship of Leu10 -teixobactin

scientific article published on 06 August 2019

Three-Dimensional Chemical Mapping of a Single Protein in the Hydrated State with Atom Probe Tomography

scientific article published on 25 March 2020

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

artículo científico publicado en 2016

Treatment options for New Delhi metallo-beta-lactamase-harboring enterobacteriaceae

artículo científico publicado en 2013

Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

article

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

scientific article published on 30 March 2017

Updated US and European Dose Recommendations for Intravenous Colistin: How Do They Perform?

artículo científico publicado en 2015

Urinary Concentrations of Colistimethate and Formed Colistin after Intravenous Administration in Patients with Multidrug-Resistant Gram-Negative Bacterial Infections.

artículo científico

Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration

artículo científico publicado en 2003

fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.

artículo científico publicado en 2010

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