Lista de obras - Hindrik Mulder - Dominio Público Uruguay

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

artículo científico publicado en 2002

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

artículo científico publicado en 2008

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

artículo científico publicado en 2011

Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion

artículo científico publicado en 1996

Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

artículo científico publicado en 2017

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

artículo científico publicado en 2006

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology

scientific journal article

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

artículo científico publicado en 2004

Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells

artículo científico publicado en 2017

CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats

scientific journal article

CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells

artículo científico publicado en 2008

Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide

artículo científico publicado en 1998

Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells

artículo científico publicado en 2015

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.

artículo científico publicado en 2016

Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

artículo científico publicado en 2017

Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease.

artículo científico publicado en 2006

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

artículo científico publicado en 2015

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells

artículo científico publicado en 2013

Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development

artículo científico publicado en 2004

Cocaine- and amphetamine-regulated transcript is increased in Huntington disease

artículo científico publicado en 2007

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

artículo científico publicado en 2008

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

artículo científico publicado en 2013

Development and optimization of a metabolomic method for analysis of adherent cell cultures

artículo científico publicado en 2010

Diabetes in Friedreich ataxia

artículo científico

Differential effect of insulin treatment on islet amyloid polypeptide (amylin) and insulin gene expression in streptozotocin-induced diabetes in rats

scientific article published on 01 March 1997

Differential expression of islet amyloid polypeptide (amylin) and insulin in experimental diabetes in rodents

scientific article published on 01 October 1995

Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence

artículo científico publicado en 2016

Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice

artículo científico publicado en 1997

Distribution of melatonin receptors in murine pancreatic islets

artículo científico publicado en 2011

Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.

artículo científico publicado en 2005

Effects of growth hormone on the function of beta-adrenoceptor subtypes in rat adipocytes

artículo científico publicado en 2004

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans

artículo científico publicado en 2013

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

artículo científico publicado en 2017

Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).

artículo científico publicado en 2004

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet

artículo científico publicado en 2006

Fracture mechanics of collagen fibrils: influence of natural cross-links

artículo científico publicado en 2013

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass

artículo científico publicado en 2003

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

artículo científico publicado en 2017

Gastric bypass improves β-cell function and increases β-cell mass in a porcine model

artículo científico publicado en 2014

Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist

artículo científico publicado en 2014

Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells

artículo científico publicado en 2004

Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoA/ROCK signaling and disassembling glucotoxicity-induced stress fibers

artículo científico publicado en 2014

Glutamate dehydrogenase, insulin secretion, and type 2 diabetes: a new means to protect the pancreatic β-cell?

artículo científico publicado en 2012

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 (GLP-1) is Governed by an Activated Glutamate Dehydrogenase

artículo científico publicado en 2017

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

scientific article published on 05 November 2016

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

artículo científico publicado en 2016

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

artículo científico publicado en 2004

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact

artículo científico publicado en 2003

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells

artículo científico publicado en 1999

Increased Insulin Secretion and Glucose Tolerance in Mice Lacking Islet Amyloid Polypeptide (Amylin) ⬇️

artículo científico publicado el 18 de septiembre de 1998

Increased metabolism in the R6/2 mouse model of Huntington's disease.

artículo científico publicado en 2007

Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion

artículo científico publicado en 2004

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

artículo científico publicado en 2015

Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic? ⬇️

artículo científico publicado el 1 de octubre de 2010

Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats

artículo científico publicado en 1996

Islet amyloid polypeptide and calcitonin gene-related peptide expression are down-regulated in dorsal root ganglia upon sciatic nerve transection ⬇️

artículo científico publicado el 1 de julio de 1997

Islet amyloid polypeptide and calcitonin gene-related peptide expression are upregulated in lumbar dorsal root ganglia after unilateral adjuvant-induced inflammation in the rat paw.

artículo científico publicado en 1997

Islet amyloid polypeptide gene expression in the endocrine pancreas of the rat: a combined in situ hybridization and immunocytochemical study

scientific article published on 01 December 1993

Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects

scientific article published on 01 January 1997

Islet amyloid polypeptide is expressed in endocrine cells of the gastric mucosa in the rat and mouse

scientific article published on 01 September 1994

Islet beta-cell area and hormone expression are unaltered in Huntington's disease

artículo científico publicado en 2008

Lipases in the pancreatic beta-cell: implications for insulin secretion

scientific article published on October 2008

Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes

scientific article published on 01 November 1994

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes

artículo científico publicado en 2014

Matrix metalloproteinases: keys to healthier blood vessels in diabetes? ⬇️

artículo científico publicado el 9 de mayo de 2011

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

scientific article published on 18 April 2009

Melatonin signalling and type 2 diabetes risk: too little, too much or just right?

artículo científico publicado en 2017

Metabolic coupling in pancreatic beta cells: lipolysis revisited

artículo científico publicado en 2016

Metabolite profile deviations in an oral glucose tolerance test-a comparison between lean and obese individuals

artículo científico publicado en 2014

Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2)

artículo científico publicado en 2012

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

artículo científico publicado en 2011

Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).

artículo científico publicado en 2007

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes

scientific article published on 07 July 2008

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

artículo científico publicado en 2017

Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase

artículo científico publicado en 1996

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion

artículo científico publicado en 2009

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

artículo científico publicado en 2017

NOS-containing neurons in the rat gut and coeliac ganglia

artículo científico publicado en 1994

Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rats islets following dexamethasone treatment

scientific article published on 01 April 1995

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

artículo científico publicado en 2018

Orexin loss in Huntington's disease.

artículo científico publicado en 2004

Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells

artículo científico publicado en 2000

Pituitary adenylate cyclase activating polypeptide (PACAP) in the gastrointestinal tract of the rat: distribution and effects of capsaicin or denervation.

artículo científico publicado en 1998

Pituitary adenylate cyclase activating polypeptide expression in sensory neurons

scientific article published on 01 November 1994

Pituitary adenylate cyclase activating polypeptide is expressed in autonomic neurons

artículo científico publicado en 1995

Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation

artículo científico publicado en 1998

Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons: functional implications from plasticity in expression on nerve injury and inflammation.

artículo científico publicado en 1999

Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics

artículo científico publicado en 2012

Precise expression of Fis1 is important for glucose responsiveness of beta cells

artículo científico publicado en 2016

Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate

artículo científico publicado en 2015

Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

artículo científico publicado en 2006

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I

artículo científico publicado en 1998

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

artículo científico publicado en 2010

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance

artículo científico publicado en 2007

Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice

scientific journal article

Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease

artículo científico publicado en 2005

Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

artículo científico publicado en 2004

Regulation of core clock genes in human islets

artículo científico publicado en 2012

Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study

artículo científico publicado en 2015

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

artículo científico publicado en 2017

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

artículo científico publicado en 2017

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

artículo científico publicado en 2021

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis

artículo científico publicado en 2005

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

artículo científico publicado en 2017

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.

artículo científico publicado en 2002

The pathogenetic role of β-cell mitochondria in type 2 diabetes

artículo científico publicado en 2018

The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration

artículo científico publicado en 2013

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

artículo científico publicado en 2009

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

artículo científico publicado en 2013

Transcribing β-cell mitochondria in health and disease

artículo científico publicado en 2017

Unaltered pancreatic islet blood perfusion in islet amyloid polypeptide-deficient mice

artículo científico publicado en 2002

Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis

artículo científico publicado en 2015

Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells

scientific article published on 01 January 2012

Lista de obras de Hindrik Mulder

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion

Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells

CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats

CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells

Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide

Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.

Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease.

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells

Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development

Cocaine- and amphetamine-regulated transcript is increased in Huntington disease

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

Development and optimization of a metabolomic method for analysis of adherent cell cultures

Diabetes in Friedreich ataxia

Differential effect of insulin treatment on islet amyloid polypeptide (amylin) and insulin gene expression in streptozotocin-induced diabetes in rats

Differential expression of islet amyloid polypeptide (amylin) and insulin in experimental diabetes in rodents

Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence

Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice

Distribution of melatonin receptors in murine pancreatic islets

Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.

Effects of growth hormone on the function of beta-adrenoceptor subtypes in rat adipocytes

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet

Fracture mechanics of collagen fibrils: influence of natural cross-links

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

Gastric bypass improves β-cell function and increases β-cell mass in a porcine model

Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist

Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells

Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoA/ROCK signaling and disassembling glucotoxicity-induced stress fibers

Glutamate dehydrogenase, insulin secretion, and type 2 diabetes: a new means to protect the pancreatic β-cell?

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 (GLP-1) is Governed by an Activated Glutamate Dehydrogenase

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells

Increased Insulin Secretion and Glucose Tolerance in Mice Lacking Islet Amyloid Polypeptide (Amylin) ⬇️

Increased metabolism in the R6/2 mouse model of Huntington's disease.

Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic? ⬇️

Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats

Islet amyloid polypeptide and calcitonin gene-related peptide expression are down-regulated in dorsal root ganglia upon sciatic nerve transection ⬇️

Islet amyloid polypeptide and calcitonin gene-related peptide expression are upregulated in lumbar dorsal root ganglia after unilateral adjuvant-induced inflammation in the rat paw.

Islet amyloid polypeptide gene expression in the endocrine pancreas of the rat: a combined in situ hybridization and immunocytochemical study

Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects

Islet amyloid polypeptide is expressed in endocrine cells of the gastric mucosa in the rat and mouse

Islet beta-cell area and hormone expression are unaltered in Huntington's disease

Lipases in the pancreatic beta-cell: implications for insulin secretion

Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes

Matrix metalloproteinases: keys to healthier blood vessels in diabetes? ⬇️

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

Melatonin signalling and type 2 diabetes risk: too little, too much or just right?

Metabolic coupling in pancreatic beta cells: lipolysis revisited

Metabolite profile deviations in an oral glucose tolerance test-a comparison between lean and obese individuals

Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2)

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

NOS-containing neurons in the rat gut and coeliac ganglia

Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rats islets following dexamethasone treatment