Lista de obras - Genhong Cheng - Dominio Público Uruguay

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

artículo científico publicado en 2017

A MyD88-dependent IFNγR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge

artículo científico publicado en 2011

A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon

artículo científico publicado en 2007

A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections

artículo científico publicado en 2006

A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses

artículo científico publicado en 2012

Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

artículo científico publicado en 2022

Asian Zika virus strains target CD14(+) blood monocytes and induce M2-skewed immunosuppression during pregnancy

artículo científico

Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies

scholarly article by Suan-Sin Foo et al published 2 November 2018 in JCI insight

Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity ⬇️

artículo científico publicado el 10 de mayo de 2012

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice

artículo científico publicado en 2011

Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice

artículo científico publicado en 2017

Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

artículo científico publicado en 2008

Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System

artículo científico publicado en 2016

Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response

artículo científico publicado en 2009

Control of canonical NF-kappaB activation through the NIK-IKK complex pathway

artículo científico publicado en 2008

Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses

artículo científico publicado en 2009

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

artículo científico publicado en 2002

Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice

artículo científico publicado en 2014

Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: A viable alternative to oseltamivir

artículo científico publicado en 2016

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism ⬇️

artículo científico publicado el 1 de octubre de 2003

Crystal structure of the ubiquitin-like domain of human TBK1 ⬇️

artículo científico publicado el 20 de mayo de 2012

Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway

artículo científico publicado en 2004

Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production

artículo científico publicado en 2007

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells ⬇️

artículo científico publicado el 24 de junio de 2011

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

artículo científico publicado en 2004

Disruption of Type I Interferon Induction by HIV Infection of T Cells

artículo científico publicado en 2015

Divergence of macrophage phagocytic and antimicrobial programs in leprosy

scientific article published on October 2009

E90 subunit vaccine protects mice from Zika virus infection and microcephaly

scholarly article by Xing-Liang Zhu et al published 10 August 2018 in Acta neuropathologica communications

Erratum to: Structural and functional analyses of human DDX41 DEAD domain

artículo científico publicado en 2017

From Mosquitos to Humans: Genetic Evolution of Zika Virus

artículo científico publicado en 2016

From plankton to pathogen recognition

article

Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase

artículo científico publicado en 2015

Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets

artículo científico publicado en 2017

Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection

artículo científico publicado en 2022

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

artículo científico publicado en 2010

IL-27 Suppresses Antimicrobial Activity in Human Leprosy

artículo científico publicado en 2015

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

artículo científico publicado en 2002

IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production

artículo científico publicado en 2007

Identification of as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx

article

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

scientific journal article

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo

artículo científico publicado en 2007

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

artículo científico publicado en 2016

Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

artículo científico publicado en 2014

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

artículo científico publicado en 2013

Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms

artículo científico publicado en 2014

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

artículo científico publicado en 2002

Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation

scientific journal article

LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells

artículo científico publicado en 2007

LXR-dependent gene expression is important for macrophage survival and the innate immune response

artículo científico publicado en 2004

Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages ⬇️

artículo científico publicado el 1 de diciembre de 2010

Macrophage differentiation from embryoid bodies derived from human embryonic stem cells

artículo científico publicado en 2009

MicroRNA-155 is induced during the macrophage inflammatory response

artículo científico publicado en 2007

Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

artículo científico publicado en 2007

MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus

artículo científico publicado en 2006

NF-kappaB inhibits gammaherpesvirus lytic replication

artículo científico publicado en 2003

NF-κB and Innate Immunity ⬇️

artículo científico publicado el 1 de enero de 2011

NF-κB: Much Learned, Much to Learn ⬇️

artículo científico publicado el 7 de septiembre de 2010

NOD so fast: NLRX1 puts the brake on inflammation

artículo científico publicado en 2011

NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy

artículo científico publicado en 2012

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation

artículo científico publicado en 2010

Network of co-mutations in Ebola virus genome predicts the disease lethality

artículo científico publicado en 2015

Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice

artículo científico publicado en 2012

New developments in the induction and antiviral effectors of type I interferon ⬇️

artículo científico publicado el 29 de noviembre de 2010

New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16

artículo científico publicado en 2016

New targets for controlling Ebola virus disease

artículo científico publicado en 2015

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

artículo científico publicado en 2008

Non‐canonical NF‐κB signaling activation and regulation: principles and perspectives ⬇️

artículo científico publicado el 1 de noviembre de 2011

PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

artículo científico publicado en 2018

PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway ⬇️

artículo científico publicado el 18 de febrero de 2011

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

artículo científico publicado en 2008

Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3

artículo científico publicado en 2011

Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo

artículo científico publicado en 2011

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS

artículo científico publicado en 2015

Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.

artículo científico publicado en 2015

Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications

artículo científico publicado en 2021

Potential for treatment and a Zika virus vaccine

artículo científico publicado en 2016

Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

artículo científico publicado en 2006

Rescue of TRAF3-null mice by p100 NF-kappa B deficiency

scientific journal article

Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon

artículo científico publicado en 2014

Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System

artículo científico publicado en 2016

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

artículo científico publicado en 2013

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

artículo científico publicado en 2017

Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5

artículo científico publicado en 2012

Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway

artículo científico publicado en 2007

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding ⬇️

artículo científico publicado el 10 de mayo de 2012

Structural and functional analyses of human DDX41 DEAD domain

artículo científico publicado en 2016

Structural basis for DNA recognition by STAT6.

artículo científico publicado en 2016

Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation

artículo científico publicado en 2013

Systematic identification of type I and type II interferon-induced antiviral factors ⬇️

artículo científico publicado el 27 de febrero de 2012

T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1).

artículo científico publicado en 2003

TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I ⬇️

artículo científico publicado el 26 de enero de 2011

TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response

artículo científico publicado en 2006

TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk

artículo científico publicado en 2005

TRAF3 and its biological function

artículo científico publicado en 2007

TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein

artículo científico publicado en 2016

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

scientific journal article

The hepatitis C virus protein NS3 suppresses TNF-α-stimulated activation of NF-κB by targeting LUBAC.

artículo científico publicado en 2015

The host type I interferon response to viral and bacterial infections

artículo científico publicado en 2005

The interferon response to bacterial and viral infections

artículo científico publicado en 2006

The signaling adaptors and pathways activated by TNF superfamily

artículo científico publicado en 2003

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

artículo científico publicado en 2008

Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4

artículo científico publicado en 2003

Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance

artículo científico publicado en 2010

Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury

artículo científico publicado en 2005

Toll-like receptors and innate antiviral responses

artículo científico publicado en 2003

Toll-like receptors induce a phagocytic gene program through p38.

artículo científico publicado en 2003

Type I IFN Promotes IL-10 Production from T Cells to Suppress Th17 Cells and Th17-Associated Autoimmune Inflammation ⬇️

artículo científico publicado el 6 de diciembre de 2011

Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication

artículo científico publicado en 2017

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

artículo científico publicado en 2009

Type I interferon production enhances susceptibility to Listeria monocytogenes infection

artículo científico publicado en 2004

Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses

artículo científico publicado en 2013

Type III interferon-induced CBFβ inhibits HBV replication by hijacking HBx.

artículo científico publicado en 2018

Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways

artículo científico publicado en 2004

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

artículo científico publicado en 2011

When Hepatitis B Virus Meets Interferons

artículo científico publicado en 2018

Zika virus shedding in the stool and infection through the anorectal mucosa in mice

scholarly article published by Yong-Qiang Deng in 2018

Lista de obras de Genhong Cheng

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

A MyD88-dependent IFNγR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge

A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon

A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections

A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses

Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

Asian Zika virus strains target CD14(+) blood monocytes and induce M2-skewed immunosuppression during pregnancy

Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies

Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity ⬇️

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice

Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice

Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System

Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response

Control of canonical NF-kappaB activation through the NIK-IKK complex pathway

Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice

Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: A viable alternative to oseltamivir

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism ⬇️

Crystal structure of the ubiquitin-like domain of human TBK1 ⬇️

Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway

Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells ⬇️

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

Disruption of Type I Interferon Induction by HIV Infection of T Cells

Divergence of macrophage phagocytic and antimicrobial programs in leprosy

E90 subunit vaccine protects mice from Zika virus infection and microcephaly

Erratum to: Structural and functional analyses of human DDX41 DEAD domain

From Mosquitos to Humans: Genetic Evolution of Zika Virus

From plankton to pathogen recognition

Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase

Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets

Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

IL-27 Suppresses Antimicrobial Activity in Human Leprosy

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production

Identification of as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation

LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells

LXR-dependent gene expression is important for macrophage survival and the innate immune response

Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages ⬇️

Macrophage differentiation from embryoid bodies derived from human embryonic stem cells

MicroRNA-155 is induced during the macrophage inflammatory response

Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus

NF-kappaB inhibits gammaherpesvirus lytic replication

NF-κB and Innate Immunity ⬇️

NF-κB: Much Learned, Much to Learn ⬇️

NOD so fast: NLRX1 puts the brake on inflammation

NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation

Network of co-mutations in Ebola virus genome predicts the disease lethality

Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice

New developments in the induction and antiviral effectors of type I interferon ⬇️

New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16

New targets for controlling Ebola virus disease

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

Non‐canonical NF‐κB signaling activation and regulation: principles and perspectives ⬇️

PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway ⬇️

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3

Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS

Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.

Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications

Potential for treatment and a Zika virus vaccine

Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

Rescue of TRAF3-null mice by p100 NF-kappa B deficiency