Lista de obras - William Leenders - Dominio Público Uruguay

-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

artículo científico publicado en 2019

A Conjugate of an Anti-Epidermal Growth Factor Receptor (EGFR) VHH and a Cell-Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation

artículo científico publicado en 2017

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker

scientific article published on 07 December 2019

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

artículo científico publicado en 2017

Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.

artículo científico publicado en 2008

Better effect of sorafenib on the rhabdoid component of a clear cell renal cell carcinoma owing to its higher level of vascular endothelial growth factor-A production

artículo científico publicado en 2011

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI.

artículo científico publicado en 2008

Characterization of tumor vasculature in mouse brain by USPIO contrast-enhanced MRI.

artículo científico publicado en 2011

Cloning and production of functional active recombinant hepatitis B virus surface antigen binding protein.

artículo científico publicado en 1994

Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

artículo científico

Contrast enhanced susceptibility weighted imaging (CE-SWI) of the mouse brain using ultrasmall superparamagnetic ironoxide particles (USPIO).

artículo científico publicado en 2006

Design of a variant of vascular endothelial growth factor-A (VEGF-A) antagonizing KDR/Flk-1 and Flt-1

scientific article published on 01 April 2002

Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies

artículo científico publicado en 2006

Development of the tumor vascular bed in response to hypoxia-induced VEGF-A differs from that in tumors with constitutive VEGF-A expression

artículo científico publicado en 2006

Effect of tyrosine kinase inhibitor treatment of renal cell carcinoma on the accumulation of carbonic anhydrase IX-specific chimeric monoclonal antibody cG250.

artículo científico publicado en 2011

Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2

artículo científico publicado en 2013

Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.

artículo científico publicado en 2011

Effects of the Green Tea Polyphenol Epigallocatechin-3-Gallate on Glioma: A Critical Evaluation of the Literature.

artículo científico publicado en 2018

EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer

artículo científico publicado en 2020

Expression and clinical relevance of MET and ALK in Ewing sarcomas.

artículo científico publicado en 2013

Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study.

artículo científico publicado en 2017

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas

artículo científico publicado en 2018

Glioma: experimental models and reality

scientific article published on 10 January 2017

Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?

artículo científico publicado en 2014

Hepatitis delta virus attaches to human hepatocytes via human liver endonexin II, a specific HBsAg binding protein.

artículo científico publicado en 1994

Host and tissue tropism of hepatitis B virus ⬇️

artículo científico publicado el 1 de abril de 1992

Hypoxia-Mediated Mechanisms Associated with Antiangiogenic Treatment Resistance in Glioblastomas.

artículo científico publicado en 2017

IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma

artículo científico publicado en 2014

IN SITU METABOLIC PROFILING SHEDS LIGHT ON OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT OLIGODENDROGLIOMA.

artículo científico publicado en 2014

Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein

artículo científico publicado en 2015

Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.

artículo científico publicado en 2016

Imaging liver metastases of colorectal cancer patients with radiolabelled bevacizumab: Lack of correlation with VEGF-A expression

artículo científico publicado en 2008

Imaging of HIV-associated Kaposi sarcoma; F-18-FDG-PET/CT and In-111-bevacizumabscintigraphy

artículo científico publicado en 2010

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

artículo científico publicado en 2017

In vivo activities of mutants of vascular endothelial growth factor (VEGF) with differential in vitro activities.

artículo científico publicado en 2001

In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued

artículo científico publicado en 2016

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.

artículo científico publicado en 2013

Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

scientific article published on 12 July 2018

Isolation of targeting nanobodies against co-opted tumor vasculature.

artículo científico publicado en 2009

Legomedicine-A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody-Nanoparticle Conjugates

artículo científico publicado en 2017

METB-09IDENTIFYING NOVEL VULNERABILITIES IN OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT GLIOMA.

artículo científico publicado en 2015

Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing

scientific article published on 20 November 2019

Molecular Profiling of Druggable Targets in Clear Cell Renal Cell Carcinoma Through Targeted RNA Sequencing

artículo científico publicado en 2019

Multivoxel ¹H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting

artículo científico publicado en 2013

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin

artículo científico publicado en 2019

Mutants of basic fibroblast growth factor identify different cellular response programs

artículo científico publicado en 1997

Neoadjuvant sorafenib treatment of clear cell renal cell carcinoma and release of circulating tumor fragments

artículo científico publicado en 2014

PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis

artículo científico publicado en 2002

Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy.

artículo científico publicado en 2008

Plexin D1 expression is induced on tumor vasculature and tumor cells: a novel target for diagnosis and therapy?

artículo científico publicado en 2005

Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies.

artículo científico publicado en 2009

Profiling of the metabolic transcriptome via single molecule molecular inversion probes.

artículo científico publicado en 2017

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases.

artículo científico publicado en 2018

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes.

artículo científico publicado en 2018

Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.

artículo científico publicado en 2015

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

artículo científico publicado en 2010

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

artículo científico publicado en 2017

Robotic injection of zebrafish embryos for high-throughput screening in disease models.

artículo científico publicado en 2013

Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity.

artículo científico publicado en 2017

Self-Assembling VHH-Elastin-Like Peptides for Photodynamic Nanomedicine.

artículo científico publicado en 2017

Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression.

artículo científico publicado en 2008

Specific imaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody

article

Synergism between temporally distinct growth factors: bFGF, insulin and lens cell differentiation

scientific article published on 01 October 1997

Targeted RNA next generation sequencing analysis of cervical smears can predict the presence of hrHPV-induced cervical lesions

artículo científico publicado en 2022

Targeted therapies of cancer: Angiogenesis inhibition seems not enough ⬇️

artículo científico publicado el 18 de diciembre de 2010

Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients.

artículo científico publicado en 2016

Targeting the extracellular matrix of ovarian cancer using functionalized, drug loaded lyophilisomes.

artículo científico publicado en 2016

Targetting VEGF in anti-angiogenic and anti-tumour therapy: where are we now?

artículo científico publicado en 1998

The Importance of Wall Apposition in Flow Diverters.

artículo científico publicado en 2018

The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates

artículo científico publicado en 2017

The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice.

artículo científico publicado en 2008

Tumor cells in search for glutamate: an alternative explanation for increased invasiveness of IDH1 mutant gliomas

artículo científico publicado en 2014

Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma.

artículo científico publicado en 2009

Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.

artículo científico publicado en 2008

Vascular endothelial growth factor in systemic capillary leak syndrome.

artículo científico publicado en 2009

Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.

artículo científico publicado en 2012

Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI.

artículo científico publicado en 2003

Vessel normalization by VEGF inhibition. A complex story.

artículo científico publicado en 2008

Lista de obras de William Leenders

-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

A Conjugate of an Anti-Epidermal Growth Factor Receptor (EGFR) VHH and a Cell-Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.

Better effect of sorafenib on the rhabdoid component of a clear cell renal cell carcinoma owing to its higher level of vascular endothelial growth factor-A production

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI.

Characterization of tumor vasculature in mouse brain by USPIO contrast-enhanced MRI.

Cloning and production of functional active recombinant hepatitis B virus surface antigen binding protein.

Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Contrast enhanced susceptibility weighted imaging (CE-SWI) of the mouse brain using ultrasmall superparamagnetic ironoxide particles (USPIO).

Design of a variant of vascular endothelial growth factor-A (VEGF-A) antagonizing KDR/Flk-1 and Flt-1

Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies

Development of the tumor vascular bed in response to hypoxia-induced VEGF-A differs from that in tumors with constitutive VEGF-A expression

Effect of tyrosine kinase inhibitor treatment of renal cell carcinoma on the accumulation of carbonic anhydrase IX-specific chimeric monoclonal antibody cG250.

Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2

Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.

Effects of the Green Tea Polyphenol Epigallocatechin-3-Gallate on Glioma: A Critical Evaluation of the Literature.

EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer

Expression and clinical relevance of MET and ALK in Ewing sarcomas.

Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study.

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas

Glioma: experimental models and reality

Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?

Hepatitis delta virus attaches to human hepatocytes via human liver endonexin II, a specific HBsAg binding protein.

Host and tissue tropism of hepatitis B virus ⬇️

Hypoxia-Mediated Mechanisms Associated with Antiangiogenic Treatment Resistance in Glioblastomas.

IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma

IN SITU METABOLIC PROFILING SHEDS LIGHT ON OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT OLIGODENDROGLIOMA.

Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein

Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.

Imaging liver metastases of colorectal cancer patients with radiolabelled bevacizumab: Lack of correlation with VEGF-A expression

Imaging of HIV-associated Kaposi sarcoma; F-18-FDG-PET/CT and In-111-bevacizumabscintigraphy

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

In vivo activities of mutants of vascular endothelial growth factor (VEGF) with differential in vitro activities.

In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.

Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

Isolation of targeting nanobodies against co-opted tumor vasculature.

Legomedicine-A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody-Nanoparticle Conjugates

METB-09IDENTIFYING NOVEL VULNERABILITIES IN OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT GLIOMA.

Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing

Molecular Profiling of Druggable Targets in Clear Cell Renal Cell Carcinoma Through Targeted RNA Sequencing

Multivoxel ¹H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin

Mutants of basic fibroblast growth factor identify different cellular response programs

Neoadjuvant sorafenib treatment of clear cell renal cell carcinoma and release of circulating tumor fragments

PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis

Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy.

Plexin D1 expression is induced on tumor vasculature and tumor cells: a novel target for diagnosis and therapy?

Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies.

Profiling of the metabolic transcriptome via single molecule molecular inversion probes.

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases.

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes.

Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

Robotic injection of zebrafish embryos for high-throughput screening in disease models.

Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity.

Self-Assembling VHH-Elastin-Like Peptides for Photodynamic Nanomedicine.

Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression.

Specific imaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody

Synergism between temporally distinct growth factors: bFGF, insulin and lens cell differentiation

Targeted RNA next generation sequencing analysis of cervical smears can predict the presence of hrHPV-induced cervical lesions

Targeted therapies of cancer: Angiogenesis inhibition seems not enough ⬇️

Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients.

Targeting the extracellular matrix of ovarian cancer using functionalized, drug loaded lyophilisomes.

Targetting VEGF in anti-angiogenic and anti-tumour therapy: where are we now?

The Importance of Wall Apposition in Flow Diverters.

The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates

The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice.

Tumor cells in search for glutamate: an alternative explanation for increased invasiveness of IDH1 mutant gliomas

Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma.

Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.

Vascular endothelial growth factor in systemic capillary leak syndrome.

Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.

Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI.

Vessel normalization by VEGF inhibition. A complex story.