Lista de obras -

A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action

article by Shi Quan Wong et al published 1 November 2018 in Journal of Neuroscience Methods

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

artículo científico publicado en 2016

A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy

artículo científico publicado en 2014

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine

artículo científico publicado en 2019

Advantages of repeated low dose against single high dose of kainate in C57BL/6J mouse model of status epilepticus: behavioral and electroencephalographic studies

artículo científico publicado en 2014

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters.

artículo científico publicado en 2016

Antiepileptic drug therapy: does mechanism of action matter?

artículo científico publicado en 2011

Antiepileptic drug therapy: does mechanism of action matter?

Antiepileptic drug transport--of mice and men.

artículo científico publicado en 2008

Binasal visual field defects are not specific to vigabatrin

artículo científico publicado en 2009

Breaching the barrier and inflaming epilepsy research

artículo científico publicado en 2009

Changing channels: mechanisms and responsiveness to antiepileptic drugs in chronic epilepsy

artículo científico publicado en 2004

Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.

artículo científico publicado en 2016

Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study ⬇️

artículo científico publicado el 1 de abril de 1998

Combining antiepileptic drugs--rational polytherapy?

artículo científico publicado en 2011

Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy

scientific article published on 04 July 2019

Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

artículo científico

Comparison of different water-miscible solvents for the preparation of plasma and urine samples in metabolic profiling studies

artículo científico publicado en 2007

Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt

artículo científico publicado en 2000

Current limitations of antiepileptic drug therapy: a conference review.

artículo científico publicado en 2003

Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice

artículo científico publicado en 2002

Differential expression of multidrug resistance genes in naïve rat brain

artículo científico publicado en 2003

Drug resistance in epilepsy: why is a simple explanation not enough?

artículo científico publicado en 2007

Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue

artículo científico publicado en 1999

Excitable but lacking in energy: contradictions in the human epileptic hippocampus

artículo científico publicado en 2006

Genetic regulation of gene expression in the epileptic human hippocampus

artículo científico publicado en 2017

Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.

artículo científico publicado en 2009

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients

artículo científico publicado en 2017

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans

artículo científico publicado en 2011

High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients ⬇️

artículo científico publicado el 1 de enero de 1998

High resolution micro-SPECT scanning in rats using 125I beta-CIT: effects of chronic treatment with carbamazepine.

artículo científico publicado en 2009

Identifying new antiepileptic drugs through genomics-based drug repurposing

artículo científico publicado en 2017

Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality

artículo científico publicado en 2015

Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?

artículo científico publicado en 2012

Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride

artículo científico publicado en 2002

Issues related to development of new antiseizure treatments

artículo científico publicado en 2013

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

artículo científico publicado en 2005

Lamotrigine and topiramate may be a useful combination

artículo científico publicado en 1998

Means, motive, and opportunity: establishing culpability in pharmacoresistant epilepsy

artículo científico publicado en 2007

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

artículo científico publicado en 2017

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

article

Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts

artículo científico publicado en 2009

NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy

artículo científico publicado en 2015

Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes

artículo científico publicado en 2002

Neurochemical actions of gabapentin in mouse brain ⬇️

artículo científico publicado el 1 de junio de 1997

Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain ⬇️

artículo científico publicado el 1 de julio de 1997

Not another gabapentin mechanism!

artículo científico publicado en 2005

Novel therapeutic strategies for epilepsy--releasing the gene Genie

artículo científico publicado en 2009

N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.

artículo científico publicado en 2012

Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models

artículo científico publicado en 2004

Pharmacogenetics of antiepileptic drug-induced hypersensitivity

artículo científico

Pharmacogenetics of epilepsy: one step forward?

artículo científico publicado en 2005

Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine.

artículo científico publicado en 2003

Predictors of pharmacoresistant epilepsy

artículo científico publicado en 2007

Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy

scientific article published on 06 March 2013

Prospective clinical trials to investigate clinical and molecular biomarkers.

artículo científico publicado en 2017

Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study

article

Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure

artículo científico publicado en 2002

Response to drug treatment in newly diagnosed epilepsy: a pilot study of (1)H NMR- and MS-based metabonomic analysis.

artículo científico publicado en 2009

SV2A in epilepsy: the plot thickens

artículo científico publicado en 2010

Seizures beget seizures: a lack of experimental evidence and clinical relevance fails to dampen enthusiasm

artículo científico publicado en 2007

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions

artículo científico publicado en 2019

Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy

scientific article published on 05 June 2007

Sudden unexpected death in epilepsy: a search for risk factors

artículo científico publicado en 2006

Sulthiame add-on therapy for epilepsy

artículo científico publicado en 2015

Sulthiame add-on therapy for epilepsy

artículo científico publicado en 2013

Sulthiame add-on therapy for epilepsy

artículo científico publicado en 2011

Sulthiame add-on therapy for epilepsy

scientific article published on 27 August 2019

Sulthiame monotherapy for epilepsy

artículo científico publicado en 2014

Sulthiame monotherapy for epilepsy

artículo científico publicado en 2012

The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis

artículo científico publicado en 2019

The mechanisms of action of gabapentin and pregabalin

artículo científico publicado en 2005

The multidrug transporter hypothesis of refractory epilepsy: corroboration and contradiction in equal measure

artículo científico publicado en 2006

Topiramate in patients with learning disability and refractory epilepsy

artículo científico publicado en 2002

Topiramate in refractory epilepsy: a prospective observational study

scientific article published on 01 August 2000

Validation of a multigenic model to predict seizure control in newly treated epilepsy.

artículo científico publicado en 2014

Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina

artículo científico publicado en 2003

Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.

artículo científico publicado en 2001

What are the arguments for and against rational therapy for epilepsy?

artículo científico

Lista de obras de

A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine

Advantages of repeated low dose against single high dose of kainate in C57BL/6J mouse model of status epilepticus: behavioral and electroencephalographic studies

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters.

Antiepileptic drug therapy: does mechanism of action matter?

Antiepileptic drug therapy: does mechanism of action matter?

Antiepileptic drug transport--of mice and men.

Binasal visual field defects are not specific to vigabatrin

Breaching the barrier and inflaming epilepsy research

Changing channels: mechanisms and responsiveness to antiepileptic drugs in chronic epilepsy

Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.

Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study ⬇️

Combining antiepileptic drugs--rational polytherapy?

Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy

Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Comparison of different water-miscible solvents for the preparation of plasma and urine samples in metabolic profiling studies

Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt

Current limitations of antiepileptic drug therapy: a conference review.

Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice

Differential expression of multidrug resistance genes in naïve rat brain

Drug resistance in epilepsy: why is a simple explanation not enough?

Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue

Excitable but lacking in energy: contradictions in the human epileptic hippocampus

Genetic regulation of gene expression in the epileptic human hippocampus

Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans

High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients ⬇️

High resolution micro-SPECT scanning in rats using 125I beta-CIT: effects of chronic treatment with carbamazepine.

Identifying new antiepileptic drugs through genomics-based drug repurposing

Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality

Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?

Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride

Issues related to development of new antiseizure treatments

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

Lamotrigine and topiramate may be a useful combination

Means, motive, and opportunity: establishing culpability in pharmacoresistant epilepsy

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts

NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy

Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes

Neurochemical actions of gabapentin in mouse brain ⬇️

Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain ⬇️

Not another gabapentin mechanism!

Novel therapeutic strategies for epilepsy--releasing the gene Genie

N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.

Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models

Pharmacogenetics of antiepileptic drug-induced hypersensitivity

Pharmacogenetics of epilepsy: one step forward?

Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine.

Predictors of pharmacoresistant epilepsy

Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy

Prospective clinical trials to investigate clinical and molecular biomarkers.

Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study

Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure

Response to drug treatment in newly diagnosed epilepsy: a pilot study of (1)H NMR- and MS-based metabonomic analysis.

SV2A in epilepsy: the plot thickens

Seizures beget seizures: a lack of experimental evidence and clinical relevance fails to dampen enthusiasm

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions

Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy

Sudden unexpected death in epilepsy: a search for risk factors

Sulthiame add-on therapy for epilepsy

Sulthiame add-on therapy for epilepsy

Sulthiame add-on therapy for epilepsy

Sulthiame add-on therapy for epilepsy

Sulthiame monotherapy for epilepsy

Sulthiame monotherapy for epilepsy

The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis

The mechanisms of action of gabapentin and pregabalin

The multidrug transporter hypothesis of refractory epilepsy: corroboration and contradiction in equal measure

Topiramate in patients with learning disability and refractory epilepsy

Topiramate in refractory epilepsy: a prospective observational study

Validation of a multigenic model to predict seizure control in newly treated epilepsy.

Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina

Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.

What are the arguments for and against rational therapy for epilepsy?