Lista de obras - David J MacEwan - Dominio Público Uruguay

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

artículo científico publicado en 2015

Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-

artículo científico publicado en 1996

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

artículo científico publicado en 2013

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

artículo científico publicado el 15 de junio de 2012

Calcium influx through 'L'-type channels into rat anterior pituitary cells can be modulated in two ways by protein kinase C (PKC-isoform selectivity of 1,2-dioctanoyl sn-glycerol?).

artículo científico publicado en 1991

Characterisation of protein kinase C isoforms and enzymic activity from the alpha T3-1 gonadotroph-derived cell line.

artículo científico publicado en 1993

Differential activation of nuclear factor-kappaB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly

artículo científico publicado en 2002

Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes

artículo científico publicado en 2003

Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis

artículo científico publicado en 2007

Elevated cPLA2 levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis

artículo científico publicado en 1996

Emerging therapeutic aspects in oncology.

artículo científico publicado en 2013

Epigenetics and pharmacology

artículo científico publicado en 2015

Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.

artículo científico publicado en 1993

Evidence that protein kinase C alpha has reduced affinity towards 1,2-dioctanoyl-sn-glycerol: the effects of lipid activators on phorbol ester binding and kinase activity.

artículo científico publicado en 1993

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

artículo científico publicado en 2018

Experimental design and analysis and their reporting: new guidance for publication in BJP.

artículo científico publicado en 2015

Functional expression of 5-HT1c receptor cDNA in COS 7 cells and its influence on protein kinase C.

artículo científico publicado en 1993

G-protein palmitoylation: regulation and functional significance.

artículo científico publicado en 1995

Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

artículo científico publicado en 2018

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

artículo científico publicado en 2008

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

artículo científico publicado el 6 de enero de 2011

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

artículo científico publicado en 2015

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

artículo científico publicado en 2014

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

artículo científico publicado en 2013

Influx of extracellular Ca2+ is necessary for electrotaxis in Dictyostelium

artículo científico publicado en 2006

Inhibition of depolarisation-induced calcium influx into GH3 cells by arachidonic acid: the involvement of protein kinase C.

artículo científico publicado en 1991

Interactions between TNF and GnRH.

artículo científico publicado en 2007

Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript

artículo científico publicado en 1993

Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells

artículo científico publicado en 1995

Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling

artículo científico publicado en 2003

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

artículo científico publicado en 2014

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome

artículo científico publicado en 2017

Oestradiol-17 beta modulates the actions of pharmacologically distinct forms of protein kinase C in rat anterior pituitary cells.

artículo científico publicado en 1993

Oxidative stress responses and NRF2 in human leukaemia

artículo científico publicado en 2015

Phorbol ester and diacylglycerol activation of native protein kinase C species from various tissues.

artículo científico publicado en 1995

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

artículo científico publicado el 1 de septiembre de 2011

Regulation of the Stoichiometry of Protein Components of the Stimulatory Adenylyl Cyclase Cascade

artículo científico publicado el 1 de enero de 1998

Silencing FLIP(L) modifies TNF-induced apoptotic protein expression.

artículo científico publicado en 2011

Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle

artículo científico publicado en 2001

TNF ligands and receptors--a matter of life and death

artículo científico publicado en 2002

TNF mediates the sustained activation of Nrf2 in human monocytes

artículo científico publicado en 2011

TNF receptor subtype signalling: differences and cellular consequences

artículo científico publicado en 2002

TNF signaling gets FLIPped off: TNF-induced regulation of FLIP.

artículo científico publicado en 2007

TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.

artículo científico publicado en 2002

TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells

artículo científico publicado en 2007

TWEAKing for a fight with GVHD.

artículo científico publicado en 2015

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

artículo científico publicado en 2015

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

artículo científico publicado en 2012

The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells.

artículo científico publicado en 2003

The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release.

artículo científico publicado en 1993

The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells

artículo científico publicado en 2011

Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylation

artículo científico publicado en 2003

Tumour necrosis factor-alpha activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle

scientific article published on 01 July 1999

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.

artículo científico publicado en 2002

Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways.

artículo científico publicado en 2001

Understanding life and death decisions in human leukaemias.

artículo científico publicado en 2014

Understanding the role of NRF2-regulated miRNAs in human malignancies.

scientific article published on August 2013

Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts

artículo científico publicado en 2017

Lista de obras de David J MacEwan

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

Calcium influx through 'L'-type channels into rat anterior pituitary cells can be modulated in two ways by protein kinase C (PKC-isoform selectivity of 1,2-dioctanoyl sn-glycerol?).

Characterisation of protein kinase C isoforms and enzymic activity from the alpha T3-1 gonadotroph-derived cell line.

Differential activation of nuclear factor-kappaB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly

Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes

Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis

Elevated cPLA2 levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis

Emerging therapeutic aspects in oncology.

Epigenetics and pharmacology

Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.

Evidence that protein kinase C alpha has reduced affinity towards 1,2-dioctanoyl-sn-glycerol: the effects of lipid activators on phorbol ester binding and kinase activity.

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

Experimental design and analysis and their reporting: new guidance for publication in BJP.

Functional expression of 5-HT1c receptor cDNA in COS 7 cells and its influence on protein kinase C.

G-protein palmitoylation: regulation and functional significance.

Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

Influx of extracellular Ca2+ is necessary for electrotaxis in Dictyostelium

Inhibition of depolarisation-induced calcium influx into GH3 cells by arachidonic acid: the involvement of protein kinase C.

Interactions between TNF and GnRH.

Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript

Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells

Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome

Oestradiol-17 beta modulates the actions of pharmacologically distinct forms of protein kinase C in rat anterior pituitary cells.

Oxidative stress responses and NRF2 in human leukaemia

Phorbol ester and diacylglycerol activation of native protein kinase C species from various tissues.

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

Regulation of the Stoichiometry of Protein Components of the Stimulatory Adenylyl Cyclase Cascade

Silencing FLIP(L) modifies TNF-induced apoptotic protein expression.

Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle

TNF ligands and receptors--a matter of life and death

TNF mediates the sustained activation of Nrf2 in human monocytes

TNF receptor subtype signalling: differences and cellular consequences

TNF signaling gets FLIPped off: TNF-induced regulation of FLIP.

TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.

TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells

TWEAKing for a fight with GVHD.

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells.

The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release.

The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells

Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylation

Tumour necrosis factor-alpha activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.

Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways.

Understanding life and death decisions in human leukaemias.

Understanding the role of NRF2-regulated miRNAs in human malignancies.

Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts