Lista de obras - Gerd Multhaup - Dominio Público Uruguay

A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification

artículo científico publicado en 2006

A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

artículo científico publicado en 2004

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms ⬇️

artículo científico publicado el 22 de noviembre de 2011

Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif

artículo científico publicado en 2010

Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies

artículo científico publicado en 2003

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization

artículo científico publicado en 2010

Amyloid precursor protein and BACE function as oligomers

artículo científico publicado en 2006

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.

artículo científico publicado en 2006

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions

artículo científico publicado en 2013

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

artículo científico publicado en 2004

Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels

artículo científico publicado en 2007

Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels

artículo científico publicado en 2007

Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

artículo científico publicado en 2004

Copper is required for prion protein-associated superoxide dismutase-I activity in Pichia pastoris

artículo científico publicado en 2007

Copper transport mediated by nanocarrier systems in a blood-brain barrier in vitro model

artículo científico publicado en 2014

Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.

artículo científico publicado en 2005

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

artículo científico publicado en 2003

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

artículo científico publicado en 2004

Dimerization of the cellular prion protein inhibits propagation of scrapie prions

artículo científico publicado en 2018

Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors

artículo científico publicado en 2013

Disturbed copper bioavailability in Alzheimer's disease

artículo científico publicado en 2011

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

artículo científico publicado en 2003

Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells

artículo científico publicado en 2006

Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

artículo científico publicado en 2008

Evidence for a copper-binding superfamily of the amyloid precursor protein

artículo científico publicado en 2002

Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization

artículo científico publicado en 2017

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

artículo científico publicado en 2007

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

artículo científico publicado en 2004

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

artículo científico publicado en 2008

Human BACE forms dimers and colocalizes with APP.

artículo científico publicado en 2004

IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

artículo científico publicado en 2007

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

artículo científico publicado en 2002

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

artículo científico publicado en 2010

Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases

artículo científico publicado en 2010

Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

artículo científico publicado en 2008

Interaction kinetics of the copper-responsive CopY repressor with the cop promoter of Enterococcus hirae

artículo científico publicado en 2004

Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

artículo científico publicado en 2015

Involvement of amyloid beta precursor protein (AbetaPP) modulated copper homeostasis in Alzheimer's disease.

artículo científico publicado en 2005

Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors?

artículo científico publicado en 2011

Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein

artículo científico publicado en 2003

Label-free distribution of anti-amyloid D-AIP in Drosophila melanogaster: prevention of Aβ42-induced toxicity without side effects in transgenic flies

scientific article published on 06 June 2019

Light‐Controlled Toxicity of Engineered Amyloid β‐Peptides ⬇️

artículo científico publicado el 19 de noviembre de 2012

Meeting Report: 7th Fabisch Symposium for Cancer Research and Molecular Cell Biology - Regulated Intramembrane Proteolysis in Cancer Development and Neurodegenerative Diseases ⬇️

artículo científico publicado el 30 de agosto de 2012

Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain

artículo científico publicado en 2012

Model peptides uncover the role of the β-secretase transmembrane sequence in metal ion mediated oligomerization

artículo científico publicado en 2013

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment

artículo científico publicado en 2003

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

artículo científico publicado en 2012

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

artículo científico publicado en 2012

Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease

artículo científico publicado en 2002

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

artículo científico publicado en 2002

Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer ⬇️

artículo científico publicado el 2 de noviembre de 2010

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

artículo científico publicado en 2009

Real-time kinetics of discontinuous and highly conformational metal-ion binding sites of prion protein.

artículo científico publicado en 2007

Specific binding of the alzheimer βA4 amyloid precursor to collagen, laminin, and heparin

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

artículo científico publicado en 2015

Structural and mechanistic implications of metal binding in the small heat-shock protein αB-crystallin

artículo científico publicado en 2011

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

artículo científico publicado en 2003

Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.

artículo científico publicado en 2009

Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer's Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity

artículo científico publicado en 2016

Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation

artículo científico publicado en 2011

The Amyloid Precursor Protein C-Terminal Fragment C100 Occurs in Monomeric and Dimeric Stable Conformations and Binds γ-Secretase Modulators ⬇️

artículo científico publicado el 11 de enero de 2011

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo

artículo científico publicado en 2005

The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization

artículo científico publicado en 2011

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

artículo científico publicado en 2011

The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.

artículo científico publicado en 2013

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

artículo científico publicado en 2012

The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species

artículo científico publicado en 2012

The proton-pump inhibitor lansoprazole enhances amyloid beta production

artículo científico publicado en 2013

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability ⬇️

artículo científico publicado el 30 de julio de 2011

Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc

artículo científico publicado en 2006

Lista de obras de Gerd Multhaup

A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification

A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms ⬇️

Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif

Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization

Amyloid precursor protein and BACE function as oligomers

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels

Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels

Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

Copper is required for prion protein-associated superoxide dismutase-I activity in Pichia pastoris

Copper transport mediated by nanocarrier systems in a blood-brain barrier in vitro model

Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

Dimerization of the cellular prion protein inhibits propagation of scrapie prions

Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors

Disturbed copper bioavailability in Alzheimer's disease

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells

Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

Evidence for a copper-binding superfamily of the amyloid precursor protein

Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

Human BACE forms dimers and colocalizes with APP.

IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases

Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

Interaction kinetics of the copper-responsive CopY repressor with the cop promoter of Enterococcus hirae

Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

Involvement of amyloid beta precursor protein (AbetaPP) modulated copper homeostasis in Alzheimer's disease.

Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors?

Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein

Label-free distribution of anti-amyloid D-AIP in Drosophila melanogaster: prevention of Aβ42-induced toxicity without side effects in transgenic flies

Light‐Controlled Toxicity of Engineered Amyloid β‐Peptides ⬇️

Meeting Report: 7th Fabisch Symposium for Cancer Research and Molecular Cell Biology - Regulated Intramembrane Proteolysis in Cancer Development and Neurodegenerative Diseases ⬇️

Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain

Model peptides uncover the role of the β-secretase transmembrane sequence in metal ion mediated oligomerization

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer ⬇️

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

Real-time kinetics of discontinuous and highly conformational metal-ion binding sites of prion protein.

Specific binding of the alzheimer βA4 amyloid precursor to collagen, laminin, and heparin

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

Structural and mechanistic implications of metal binding in the small heat-shock protein αB-crystallin

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.

Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer's Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity

Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation

The Amyloid Precursor Protein C-Terminal Fragment C100 Occurs in Monomeric and Dimeric Stable Conformations and Binds γ-Secretase Modulators ⬇️

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo

The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species

The proton-pump inhibitor lansoprazole enhances amyloid beta production

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability ⬇️

Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc