Lista de obras -

A new series of ferrocifen derivatives, bearing two aminoalkyl chains, with strong antiproliferative effects on breast cancer cells

Administration-dependent efficacy of ferrociphenol lipid nanocapsules for the treatment of intracranial 9L rat gliosarcoma.

artículo científico publicado en 2011

Analytical potential of near-infrared fourier transform Raman spectra in the detection of solid transition metal carbonyl steroid hormones

Brain tumour targeting strategies via coated ferrociphenol lipid nanocapsules.

artículo científico publicado en 2012

Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells

article

Cytotoxic triosmium carbonyl clusters: a structure-activity relationship study

artículo científico publicado en 2014

Deciphering the activation sequence of ferrociphenol anticancer drug candidates.

artículo científico publicado en 2012

Dose effect activity of ferrocifen-loaded lipid nanocapsules on a 9L-glioma model.

artículo científico publicado en 2009

Efficient new constructs against triple negative breast cancer cells: synthesis and preliminary biological study of ferrocifen-SAHA hybrids and related species.

artículo científico publicado en 2013

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series

Evaluation of cytotoxic properties of organometallic ferrocifens on melanocytes, primary and metastatic melanoma cell lines

artículo científico publicado en 2008

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

artículo científico publicado en 2014

FACS analysis of oxidative stress induced on tumour cells by SERMs

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation

artículo científico publicado en 2016

Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells.

artículo científico publicado en 2012

Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells.

artículo científico publicado en 2011

Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

artículo científico publicado en 2009

Ferrocifen derivatives that induce senescence in cancer cells: selected examples

artículo científico publicado en 2014

Ferrocifen type anti cancer drugs

artículo científico publicado en 2015

Ferrocifens and Ferrocifenols as New Potential Weapons against Breast Cancer

Ferrocifens labelled with an infrared rhenium tricarbonyl tag: synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells

artículo científico publicado en 2018

Ferrociphenol lipid nanocapsule delivery by mesenchymal stromal cells in brain tumor therapy.

artículo científico publicado en 2011

First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

scholarly article by Gérard Jaouen et al published 2001 in Chemical Communications

First attachment of the stable organometallic moiety 〚Re(CO) 3 (η 5 -C 5 H 4 –C≡C–)〛 at position 11ß of oestradiol. Biochemical behaviour of the complex

In vitro inhibitory properties of ferrocene-substituted chalcones and aurones on bacterial and human cell cultures.

artículo científico publicado en 2012

Influence of the side-chain length on the cellular uptake and the cytotoxicity of rhenium triscarbonyl derivatives: a bimodal infrared and luminescence quantitative study

artículo científico publicado en 2014

Inhibition of ectopic glioma tumor growth by a potent ferrocenyl drug loaded into stealth lipid nanocapsules

artículo científico publicado en 2014

Intracellular Localization of an Osmocenyl-Tamoxifen Derivative in Breast Cancer Cells Revealed by Synchrotron Radiation X-ray Fluorescence Nanoimaging

scientific article published on 06 February 2019

Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas.

artículo científico publicado en 2008

Local delivery of ferrociphenol lipid nanocapsules followed by external radiotherapy as a synergistic treatment against intracranial 9L glioma xenograft.

artículo científico publicado en 2009

Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro

artículo científico publicado en 2005

Nanoparticles loaded with ferrocenyl tamoxifen derivatives for breast cancer treatment

artículo científico publicado en 2007

New Synthetic Pathways ofcis- ortrans-Hydroxytamoxifen Derivatives with in Situ Formed [Cp*Rh(solvent)3]2+Complexes: Kinetic and Thermodynamic Control, Including a Novel, Intramolecular N-π Rearrangement, and Relative Binding Affinities of the η6Co

New and efficient routes to CpRe(CO)3 substituted steroids

New paradigms for synthetic pathways inspired by bioorganometallic chemistry

Organometallic analogues of tamoxifen: Effect of the amino side-chain replacement by a carbonyl ferrocenyl moiety in hydroxytamoxifen

Organometallic cyclic polyphenols derived from 1,2-(alpha-keto tri or tetra methylene) ferrocene show strong antiproliferative activity on hormone-independent breast cancer cells.

artículo científico publicado en 2010

Organometallic diphenols: The importance of the organometallic moiety on the expression of a cytotoxic effect on breast cancer cells

Osmocenyl-tamoxifen derivatives target the thioredoxin system leading to a redox imbalance in Jurkat cells.

artículo científico publicado en 2016

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

artículo científico publicado en 2015

Patterns of pulmonary tuberculosis on FDG-PET/CT.

artículo científico publicado en 2011

Platinum(II) and technetium(I) complexes anchored to ethynylestradiol: a way to drug targeting and delivery

Quantitative analyses of ROS and RNS production in breast cancer cell lines incubated with ferrocifens.

artículo científico publicado en 2014

Reactivity and antiproliferative activity of ferrocenyl-tamoxifen adducts with cyclodextrins against hormone-independent breast-cancer cell lines.

artículo científico publicado en 2008

Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds

artículo científico publicado en 2009

Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior.

artículo científico publicado en 2005

Selective estrogen-receptor modulators (SERMs) in the cyclopentadienylrhenium tricarbonyl series: synthesis and biological behaviour.

artículo científico publicado en 2004

Site-specific conjugation of metal carbonyl dendrimer to antibody and its use as detection reagent in immunoassay.

artículo científico publicado en 2010

Small Structural Differences between Two Ferrocenyl Diphenols Determine Large Discrepancies of Reactivity and Biological Effects

scientific article published on 24 September 2019

Studies on organometallic selective estrogen receptor modulators. (SERMs) Dual activity in the hydroxy-ferrocifen series

Subcellular IR imaging of a metal-carbonyl moiety using photothermally induced resonance

artículo científico publicado en 2010

Surface grafting of a π-conjugated amino-ferrocifen drug

Synchrotron radiation FTIR detection of a metal-carbonyl tamoxifen analog. Correlation with luminescence microscopy to study its subcellular distribution.

artículo científico publicado en 2012

Synthesis and Antiproliferative Effects of [3]Ferrocenophane Transposition Products and Pinacols Obtained from McMurry Cross-Coupling Reactions

Synthesis and Structure Activity Relationship of Organometallic Steroidal Androgen Derivatives

Synthesis and antiproliferative activity of hydroxyferrocifen hybrids against triple-negative breast cancer cells

artículo científico publicado en 2014

Synthesis and antiproliferative evaluation of ferrocenyl and cymantrenyl triaryl butene on breast cancer cells. Biodistribution study of the corresponding technetium-99m tamoxifen conjugate

Synthesis and biological activity of ferrocenyl derivatives of the non-steroidal antiandrogens flutamide and bicalutamide

Synthesis and structure-activity relationships of ferrocenyl tamoxifen derivatives with modified side chains

artículo científico publicado en 2009

Synthesis and structure-activity relationships of the first ferrocenyl-aryl-hydantoin derivatives of the nonsteroidal antiandrogen nilutamide

artículo científico publicado en 2008

Synthesis of Optically Pureo-Formylcyclopentadienyl Metal Complexes of 17α-Ethynylestradiol. Recognition of the Planar Chirality by the Estrogen Receptor

Synthesis of metal-carbonyl-dendrimer-antibody immunoconjugates: towards a new format for carbonyl metallo immunoassay.

artículo científico publicado en 2004

Synthesis, Characterization, and Biological Properties of Osmium-Based Tamoxifen Derivatives - Comparison with Their Homologues in the Iron and Ruthenium Series

scholarly article by Hui Zhi Shirley Lee et al published 11 August 2015 in European Journal of Inorganic Chemistry

Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone

artículo científico publicado en 2003

Synthesis, cytotoxicity, and COMPARE analysis of ferrocene and [3]ferrocenophane tetrasubstituted olefin derivatives against human cancer cells

artículo científico publicado en 2010

Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

artículo científico publicado en 2009

Synthetic and mechanistic pathways of cis and trans-hydroxytamoxifen drug derivatives reacting with Cp*Rh complexes that involve η1-N, η2-N,O, η1-O, and η6 bonding modes, via a novel N-π rearrangement; relative binding affinities and computer dockin

artículo científico publicado en 2010

Synthetic strategy for organometallic complexes of rhenium with exceptionally high affinity for the oestradiol receptor; their potential use as imaging and therapeutic agents

scholarly article by Siden Top et al published 1994 in Journal of the Chemical Society. Chemical communications

Tamoxifen derivatives for delivery of the antitumoral (DACH)Pt group: selective synthesis by McMurry coupling, and biochemical behaviour

artículo científico publicado en 2003

Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells.

artículo científico publicado en 2017

Targeting and treatment of glioblastomas with human mesenchymal stem cells carrying ferrociphenol lipid nanocapsules.

artículo científico publicado en 2015

The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer.

artículo científico publicado en 2013

The presence of a ferrocenyl unit on an estrogenic molecule is not always sufficient to generate in vitro cytotoxicity.

artículo científico publicado en 2006

The replacement of a phenol group by an aniline or acetanilide group enhances the cytotoxicity of 2-ferrocenyl-1,1-diphenyl-but-l-ene compounds against breast cancer cells

Treatment of 9L gliosarcoma in rats by ferrociphenol-loaded lipid nanocapsules based on a passive targeting strategy via the EPR effect

artículo científico publicado en 2011

Lista de obras de

A new series of ferrocifen derivatives, bearing two aminoalkyl chains, with strong antiproliferative effects on breast cancer cells

Administration-dependent efficacy of ferrociphenol lipid nanocapsules for the treatment of intracranial 9L rat gliosarcoma.

Analytical potential of near-infrared fourier transform Raman spectra in the detection of solid transition metal carbonyl steroid hormones

Brain tumour targeting strategies via coated ferrociphenol lipid nanocapsules.

Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells

Cytotoxic triosmium carbonyl clusters: a structure-activity relationship study

Deciphering the activation sequence of ferrociphenol anticancer drug candidates.

Dose effect activity of ferrocifen-loaded lipid nanocapsules on a 9L-glioma model.

Efficient new constructs against triple negative breast cancer cells: synthesis and preliminary biological study of ferrocifen-SAHA hybrids and related species.

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series

Evaluation of cytotoxic properties of organometallic ferrocifens on melanocytes, primary and metastatic melanoma cell lines

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

FACS analysis of oxidative stress induced on tumour cells by SERMs

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation

Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells.

Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells.

Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

Ferrocifen derivatives that induce senescence in cancer cells: selected examples

Ferrocifen type anti cancer drugs

Ferrocifens and Ferrocifenols as New Potential Weapons against Breast Cancer

Ferrocifens labelled with an infrared rhenium tricarbonyl tag: synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells

Ferrociphenol lipid nanocapsule delivery by mesenchymal stromal cells in brain tumor therapy.

First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

First attachment of the stable organometallic moiety 〚Re(CO) 3 (η 5 -C 5 H 4 –C≡C–)〛 at position 11ß of oestradiol. Biochemical behaviour of the complex

In vitro inhibitory properties of ferrocene-substituted chalcones and aurones on bacterial and human cell cultures.

Influence of the side-chain length on the cellular uptake and the cytotoxicity of rhenium triscarbonyl derivatives: a bimodal infrared and luminescence quantitative study

Inhibition of ectopic glioma tumor growth by a potent ferrocenyl drug loaded into stealth lipid nanocapsules

Intracellular Localization of an Osmocenyl-Tamoxifen Derivative in Breast Cancer Cells Revealed by Synchrotron Radiation X-ray Fluorescence Nanoimaging

Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas.

Local delivery of ferrociphenol lipid nanocapsules followed by external radiotherapy as a synergistic treatment against intracranial 9L glioma xenograft.

Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro

Nanoparticles loaded with ferrocenyl tamoxifen derivatives for breast cancer treatment

New Synthetic Pathways ofcis- ortrans-Hydroxytamoxifen Derivatives with in Situ Formed [Cp*Rh(solvent)3]2+Complexes: Kinetic and Thermodynamic Control, Including a Novel, Intramolecular N-π Rearrangement, and Relative Binding Affinities of the η6Co

New and efficient routes to CpRe(CO)3 substituted steroids

New paradigms for synthetic pathways inspired by bioorganometallic chemistry

Organometallic analogues of tamoxifen: Effect of the amino side-chain replacement by a carbonyl ferrocenyl moiety in hydroxytamoxifen

Organometallic cyclic polyphenols derived from 1,2-(alpha-keto tri or tetra methylene) ferrocene show strong antiproliferative activity on hormone-independent breast cancer cells.

Organometallic diphenols: The importance of the organometallic moiety on the expression of a cytotoxic effect on breast cancer cells

Osmocenyl-tamoxifen derivatives target the thioredoxin system leading to a redox imbalance in Jurkat cells.

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

Patterns of pulmonary tuberculosis on FDG-PET/CT.

Platinum(II) and technetium(I) complexes anchored to ethynylestradiol: a way to drug targeting and delivery

Quantitative analyses of ROS and RNS production in breast cancer cell lines incubated with ferrocifens.

Reactivity and antiproliferative activity of ferrocenyl-tamoxifen adducts with cyclodextrins against hormone-independent breast-cancer cell lines.

Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds

Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior.

Selective estrogen-receptor modulators (SERMs) in the cyclopentadienylrhenium tricarbonyl series: synthesis and biological behaviour.

Site-specific conjugation of metal carbonyl dendrimer to antibody and its use as detection reagent in immunoassay.

Small Structural Differences between Two Ferrocenyl Diphenols Determine Large Discrepancies of Reactivity and Biological Effects

Studies on organometallic selective estrogen receptor modulators. (SERMs) Dual activity in the hydroxy-ferrocifen series

Subcellular IR imaging of a metal-carbonyl moiety using photothermally induced resonance

Surface grafting of a π-conjugated amino-ferrocifen drug

Synchrotron radiation FTIR detection of a metal-carbonyl tamoxifen analog. Correlation with luminescence microscopy to study its subcellular distribution.

Synthesis and Antiproliferative Effects of [3]Ferrocenophane Transposition Products and Pinacols Obtained from McMurry Cross-Coupling Reactions

Synthesis and Structure Activity Relationship of Organometallic Steroidal Androgen Derivatives

Synthesis and antiproliferative activity of hydroxyferrocifen hybrids against triple-negative breast cancer cells

Synthesis and antiproliferative evaluation of ferrocenyl and cymantrenyl triaryl butene on breast cancer cells. Biodistribution study of the corresponding technetium-99m tamoxifen conjugate

Synthesis and biological activity of ferrocenyl derivatives of the non-steroidal antiandrogens flutamide and bicalutamide

Synthesis and structure-activity relationships of ferrocenyl tamoxifen derivatives with modified side chains

Synthesis and structure-activity relationships of the first ferrocenyl-aryl-hydantoin derivatives of the nonsteroidal antiandrogen nilutamide

Synthesis of Optically Pureo-Formylcyclopentadienyl Metal Complexes of 17α-Ethynylestradiol. Recognition of the Planar Chirality by the Estrogen Receptor

Synthesis of metal-carbonyl-dendrimer-antibody immunoconjugates: towards a new format for carbonyl metallo immunoassay.

Synthesis, Characterization, and Biological Properties of Osmium-Based Tamoxifen Derivatives - Comparison with Their Homologues in the Iron and Ruthenium Series

Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone

Synthesis, cytotoxicity, and COMPARE analysis of ferrocene and [3]ferrocenophane tetrasubstituted olefin derivatives against human cancer cells

Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

Synthetic and mechanistic pathways of cis and trans-hydroxytamoxifen drug derivatives reacting with Cp*Rh complexes that involve η1-N, η2-N,O, η1-O, and η6 bonding modes, via a novel N-π rearrangement; relative binding affinities and computer dockin

Synthetic strategy for organometallic complexes of rhenium with exceptionally high affinity for the oestradiol receptor; their potential use as imaging and therapeutic agents

Tamoxifen derivatives for delivery of the antitumoral (DACH)Pt group: selective synthesis by McMurry coupling, and biochemical behaviour

Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells.

Targeting and treatment of glioblastomas with human mesenchymal stem cells carrying ferrociphenol lipid nanocapsules.

The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer.

The presence of a ferrocenyl unit on an estrogenic molecule is not always sufficient to generate in vitro cytotoxicity.

The replacement of a phenol group by an aniline or acetanilide group enhances the cytotoxicity of 2-ferrocenyl-1,1-diphenyl-but-l-ene compounds against breast cancer cells

Treatment of 9L gliosarcoma in rats by ferrociphenol-loaded lipid nanocapsules based on a passive targeting strategy via the EPR effect