Lista de obras -

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

artículo científico publicado en 2015

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

artículo científico publicado en 2016

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

artículo científico publicado en 2018

A light-gated potassium channel for sustained neuronal inhibition

artículo científico publicado en 2018

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

artículo científico publicado en 2015

A porcine model of neurofibromatosis type 1 that mimics the human disease

scientific article published on 21 June 2018

A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

artículo científico publicado en 2017

Activity of T-type calcium channels is independent of CRMP2 in sensory neurons

artículo científico publicado en 2019

Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1

scientific article published on 01 November 2019

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

artículo científico publicado en 2019

Blocking CRMP2 SUMOylation reverses neuropathic pain

scholarly article by Aubin Moutal published in November 2018

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

artículo científico publicado en 2017

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.

artículo científico publicado en 2017

CRMP2 is necessary for Neurofibromatosis type 1 related pain.

artículo científico

CRMP2-Neurofibromin Interface Drives NF1-related Pain

artículo científico publicado en 2018

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.

artículo científico publicado en 2015

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

scientific article published on 26 July 2018

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel

artículo científico publicado en 2021

Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant

artículo científico publicado en 2019

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides

artículo científico publicado en 2014

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

artículo científico publicado en 2017

Druggability of CRMP2 for neurodegenerative diseases

artículo científico publicado en 2020

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions

artículo científico publicado en 2019

Efficacy of (S)-Lacosamide in preclinical models of cephalic pain

artículo científico publicado en 2016

Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief

scientific article published on 01 December 2019

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential

artículo científico publicado en 2017

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

artículo científico publicado en 2016

High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons

artículo científico publicado en 2018

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

artículo científico publicado en 2017

In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein

artículo científico publicado en 2020

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

scientific article published on 01 October 2018

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

artículo científico publicado en 2017

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission

artículo científico publicado en 2018

Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.

artículo científico publicado en 2018

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

artículo científico publicado en 2020

Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.

artículo científico publicado en 2016

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

scientific article published on 11 June 2020

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

artículo científico publicado en 2016

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

scientific article published on 03 July 2020

Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

scientific article published on 01 July 2020

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

artículo científico publicado en 2017

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

scientific article published on 01 July 2019

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

artículo científico publicado en 2014

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

artículo científico publicado en 2020

Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.

artículo científico publicado en 2017

Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?

artículo científico publicado en 2018

Lista de obras de

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

A light-gated potassium channel for sustained neuronal inhibition

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

A porcine model of neurofibromatosis type 1 that mimics the human disease

A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

Activity of T-type calcium channels is independent of CRMP2 in sensory neurons

Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

Blocking CRMP2 SUMOylation reverses neuropathic pain

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.

CRMP2 is necessary for Neurofibromatosis type 1 related pain.

CRMP2-Neurofibromin Interface Drives NF1-related Pain

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel

Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

Druggability of CRMP2 for neurodegenerative diseases

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions

Efficacy of (S)-Lacosamide in preclinical models of cephalic pain

Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission

Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.

Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?