Lista de obras - Elżbieta Wyska - Dominio Público Uruguay

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

artículo científico publicado en 2020

A model for treating avian aspergillosis: serum and lung tissue kinetics for Japanese quail (Coturnix japonica) following single and multiple aerosol exposures of a nanoparticulate itraconazole suspension

artículo científico publicado en 2013

A new class of 5-HT 1A receptor antagonists with procognitive and antidepressant properties

artículo científico publicado en 2021

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS.

artículo científico publicado en 2016

Activity and Safety of Inhaled Itraconazole Nanosuspension in a Model Pulmonary Aspergillus fumigatus Infection in Inoculated Young Quails

artículo científico publicado en 2015

Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies

scientific article published on 01 August 2019

Advances in Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 1: Overview of the Chemical and Biological Research

artículo científico publicado en 2019

Advances in the Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 2: Focus on Schizophrenia

artículo científico publicado en 2019

Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist

scientific article published on 16 March 2019

Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice.

artículo científico publicado en 2014

Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests

artículo científico publicado en 2019

Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies

artículo científico publicado en 2021

Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A2A Receptor Antagonist

artículo científico publicado en 2018

Antidepressant-like activity of sildenafil following acute and subchronic treatment in the forced swim test in mice: effects of restraint stress and monoamine depletion.

artículo científico publicado en 2016

Application of real-time PCR to pharmacokinetic studies

artículo científico publicado en 2006

Approaches to pharmacokinetic/ pharmacodynamic modeling during pregnancy

artículo científico publicado en 2001

CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers

artículo científico publicado en 2012

Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice.

artículo científico publicado en 2015

Caffeine enhances the antidepressant-like activity of common antidepressant drugs in the forced swim test in mice

artículo científico publicado en 2015

Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11.

artículo científico publicado en 2019

Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression.

artículo científico publicado en 2017

Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

artículo científico publicado en 2020

Contemporary concepts in studies on cyclic AMP and its role in the inflammatory reaction

artículo científico publicado en 2015

Correction to: Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

scientific article published on 21 January 2020

Cytochrome P450 oxidoreductase genetic polymorphism and pantoprazole pharmacokinetics in healthy volunteers

artículo científico publicado en 2018

DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests

scholarly article by Aleksandra Szopa et al published December 2018 in Naunyn-Schmiedeberg's Archives of Pharmacology

Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer’s Disease

artículo científico publicado en 2021

Discovery of novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor Biased Agonists: Diversified Therapeutic-Like vs. Side Effects Profile

artículo científico publicado en 2020

Diversity of mechanism-based pharmacodynamic models

artículo científico publicado en 2003

Effect of Pterostilbene, a Natural Analog of Resveratrol, on the Activity of some Antiepileptic Drugs in the Acute Seizure Tests in Mice

artículo científico publicado en 2019

Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice.

artículo científico publicado en 2018

Effect of sildenafil on the activity of some antidepressant drugs and electroconvulsive shock treatment in the forced swim test in mice

artículo científico publicado en 2016

Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish

artículo científico publicado en 2021

Enantioselective analysis of ibuprofen enantiomers in mice plasma and tissues by high-performance liquid chromatography with fluorescence detection: Application to a pharmacokinetic study.

artículo científico publicado en 2017

Enhancement of antidepressant-like activity by joint administration of imipramine and magnesium in the forced swim test: Behavioral and pharmacokinetic studies in mice

artículo científico publicado en 2005

High-Energy Ball Milling as Green Process To Vitrify Tadalafil and Improve Bioavailability

artículo científico publicado en 2016

Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides

artículo científico publicado en 2021

Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine

artículo científico publicado en 2006

In vitro and in vivo behavior of ground tadalafil hot-melt extrudates: How the carrier material can effectively assure rapid or controlled drug release.

artículo científico publicado en 2017

Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice.

artículo científico publicado en 2017

Influence of inflammatory disorders on pharmacokinetics of lisofylline in rats: implications for studies in humans

artículo científico publicado en 2018

Influence of sildenafil on the antidepressant activity of bupropion and venlafaxine in the forced swim test in mice ⬇️

artículo científico publicado el 25 de agosto de 2012

Influence of the CB1 and CB2 cannabinoid receptor ligands on the activity of atypical antidepressant drugs in the behavioural tests in mice

scientific article published on 27 November 2019

Influence of the CB1 cannabinoid receptors on the activity of the monoaminergic system in the behavioural tests in mice

scientific article published on 31 May 2019

Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice

artículo científico publicado en 2020

Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice.

artículo científico publicado en 2016

Inhalable highly concentrated itraconazole nanosuspension for the treatment of bronchopulmonary aspergillosis

scientific article published on 12 October 2012

Interconversion and tissue distribution of pentoxifylline and lisofylline in mice

artículo científico publicado en 2006

KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies

artículo científico publicado en 2020

Late Breaking Abstract - Anti-inflammatory and anti-fibrotic effect of novel, pan-PDE inhibitors in human bronchial epithelial cells

artículo científico publicado en 2020

Ligands of the CB2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice

scientific article published on 15 October 2019

Methods of estimation of IC50 and SC50 parameters for indirect response models from single dose data

artículo científico publicado en 2003

Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia

artículo científico publicado en 2021

New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases

artículo científico publicado en 2020

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity

scientific article published on 02 March 2019

Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

artículo científico publicado en 2018

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity

scientific article published on 17 June 2020

Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.

artículo científico publicado en 2018

Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling

scientific article published on 06 November 2019

Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties

artículo científico publicado en 2016

PDE7-Selective and Dual Inhibitors: Advances in Chemical and Biological Research.

artículo científico publicado en 2017

PK/PD Modeling of the PDE7 Inhibitor-GRMS-55 in a Mouse Model of Autoimmune Hepatitis

artículo científico publicado en 2021

PK/PD studies on non-selective PDE inhibitors in rats using cAMP as a marker of pharmacological response.

artículo científico publicado en 2017

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

artículo científico publicado en 2022

Pharmacokinetic considerations for current state-of-the-art antidepressants

scientific article published on 23 September 2019

Pharmacokinetic interaction after joint administration of zinc and imipramine in forced swim test in mice

artículo científico publicado en 2004

Pharmacokinetic interaction between imipramine and carbamazepine in patients with major depression

artículo científico publicado en 2001

Pharmacokinetic interaction between verapamil and methylxanthine derivatives in mice

artículo científico publicado en 2010

Pharmacokinetic modelling of pentoxifylline and lisofylline after oral and intravenous administration in mice

artículo científico publicado en 2007

Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

artículo científico publicado en 2017

Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.

artículo científico publicado en 2010

Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide

artículo científico publicado en 2010

Pharmacokinetic-pharmacodynamic relationship of rocuronium under stable nitrous oxide-fentanyl or nitrous oxide-sevoflurane anesthesia in children

artículo científico publicado en 2006

Pharmacokinetics and pharmacodynamics of erythropoietin receptor in healthy volunteers

artículo científico publicado en 2007

Pharmacokinetics and tissue distribution of the new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy) propyl]piperidine in rats.

artículo científico publicado en 2015

Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice

artículo científico publicado en 2015

Population pharmacokinetic analysis of ciprofloxacin in the elderly patients with lower respiratory tract infections

artículo científico publicado en 2014

Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock

artículo científico publicado en 2009

Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study.

artículo científico publicado en 2015

Sevoflurane increases fade of neuromuscular response to TOF stimulation following rocuronium administration in children. A PK/PD analysis

artículo científico publicado en 2007

Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the activity of two atypical antidepressant drugs, mianserin and tianeptine, in the forced swim test in mice ⬇️

artículo científico publicado el 3 de marzo de 2012

Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice ⬇️

artículo científico publicado el 4 de enero de 2012

Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice ⬇️

artículo científico publicado el 1 de enero de 2012

Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents

artículo científico publicado en 2021

Synthesis of 8-alkoxy-1,3-dimethyl-2, 6-dioxopurin-7-yl-substituted acetohydrazides and butanehydrazides as analgesic and anti-inflammatory agents

artículo científico publicado en 2015

The Effects and Mechanisms of Action of TC-G 1008, GPR39 Agonist, in Animal Models of Seizures and Epilepsy

artículo científico publicado en 2022

The impact of polymers on 3D microstructure and controlled release of sildenafil citrate from hydrophilic matrices

scientific article published on 19 April 2018

The influence of caffeine on the activity of moclobemide, venlafaxine, bupropion and milnacipran in the forced swim test in mice

artículo científico publicado en 2015

The influence of selective A1 and A2A receptor antagonists on the antidepressant-like activity of moclobemide, venlafaxine and bupropion in mice

artículo científico publicado en 2018

Traxoprodil augments the antidepressant-like activity of agomelatine but not of mianserin or tianeptine in the forced swim test in mice.

artículo científico publicado en 2016

Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice.

artículo científico publicado en 2016

Withdrawal of caffeine after its chronic administration modifies the antidepressant-like activity of atypical antidepressants in mice. Changes in cortical expression of Comt, Slc6a15 and Adora1 genes

artículo científico publicado en 2018

[Clinical pharmacokinetics of tricyclic antidepressants Part II. Drug therapy monitoring]

artículo científico publicado en 1994

[Clinical pharmacokinetics of tricyclic antidepressants. Part I. Pharmacokinetic properties]

scientific article published on 01 November 1993

Lista de obras de Elżbieta Wyska

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

A model for treating avian aspergillosis: serum and lung tissue kinetics for Japanese quail (Coturnix japonica) following single and multiple aerosol exposures of a nanoparticulate itraconazole suspension

A new class of 5-HT 1A receptor antagonists with procognitive and antidepressant properties

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS.

Activity and Safety of Inhaled Itraconazole Nanosuspension in a Model Pulmonary Aspergillus fumigatus Infection in Inoculated Young Quails

Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies

Advances in Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 1: Overview of the Chemical and Biological Research

Advances in the Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 2: Focus on Schizophrenia

Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist

Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice.

Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests

Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies

Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A2A Receptor Antagonist

Antidepressant-like activity of sildenafil following acute and subchronic treatment in the forced swim test in mice: effects of restraint stress and monoamine depletion.

Application of real-time PCR to pharmacokinetic studies

Approaches to pharmacokinetic/ pharmacodynamic modeling during pregnancy

CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers

Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice.

Caffeine enhances the antidepressant-like activity of common antidepressant drugs in the forced swim test in mice

Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11.

Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression.

Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

Contemporary concepts in studies on cyclic AMP and its role in the inflammatory reaction

Correction to: Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

Cytochrome P450 oxidoreductase genetic polymorphism and pantoprazole pharmacokinetics in healthy volunteers

DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests

Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer’s Disease

Discovery of novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor Biased Agonists: Diversified Therapeutic-Like vs. Side Effects Profile

Diversity of mechanism-based pharmacodynamic models

Effect of Pterostilbene, a Natural Analog of Resveratrol, on the Activity of some Antiepileptic Drugs in the Acute Seizure Tests in Mice

Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice.

Effect of sildenafil on the activity of some antidepressant drugs and electroconvulsive shock treatment in the forced swim test in mice

Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish

Enantioselective analysis of ibuprofen enantiomers in mice plasma and tissues by high-performance liquid chromatography with fluorescence detection: Application to a pharmacokinetic study.

Enhancement of antidepressant-like activity by joint administration of imipramine and magnesium in the forced swim test: Behavioral and pharmacokinetic studies in mice

High-Energy Ball Milling as Green Process To Vitrify Tadalafil and Improve Bioavailability

Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides

Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine

In vitro and in vivo behavior of ground tadalafil hot-melt extrudates: How the carrier material can effectively assure rapid or controlled drug release.

Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice.

Influence of inflammatory disorders on pharmacokinetics of lisofylline in rats: implications for studies in humans

Influence of sildenafil on the antidepressant activity of bupropion and venlafaxine in the forced swim test in mice ⬇️

Influence of the CB1 and CB2 cannabinoid receptor ligands on the activity of atypical antidepressant drugs in the behavioural tests in mice

Influence of the CB1 cannabinoid receptors on the activity of the monoaminergic system in the behavioural tests in mice

Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice

Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice.

Inhalable highly concentrated itraconazole nanosuspension for the treatment of bronchopulmonary aspergillosis

Interconversion and tissue distribution of pentoxifylline and lisofylline in mice

KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies

Late Breaking Abstract - Anti-inflammatory and anti-fibrotic effect of novel, pan-PDE inhibitors in human bronchial epithelial cells

Ligands of the CB2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice

Methods of estimation of IC50 and SC50 parameters for indirect response models from single dose data

Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia

New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity

Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity

Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.

Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling

Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties

PDE7-Selective and Dual Inhibitors: Advances in Chemical and Biological Research.

PK/PD Modeling of the PDE7 Inhibitor-GRMS-55 in a Mouse Model of Autoimmune Hepatitis

PK/PD studies on non-selective PDE inhibitors in rats using cAMP as a marker of pharmacological response.

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

Pharmacokinetic considerations for current state-of-the-art antidepressants

Pharmacokinetic interaction after joint administration of zinc and imipramine in forced swim test in mice

Pharmacokinetic interaction between imipramine and carbamazepine in patients with major depression

Pharmacokinetic interaction between verapamil and methylxanthine derivatives in mice

Pharmacokinetic modelling of pentoxifylline and lisofylline after oral and intravenous administration in mice

Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.

Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide

Pharmacokinetic-pharmacodynamic relationship of rocuronium under stable nitrous oxide-fentanyl or nitrous oxide-sevoflurane anesthesia in children

Pharmacokinetics and pharmacodynamics of erythropoietin receptor in healthy volunteers

Pharmacokinetics and tissue distribution of the new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy) propyl]piperidine in rats.

Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice

Population pharmacokinetic analysis of ciprofloxacin in the elderly patients with lower respiratory tract infections

Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock

Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study.

Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies