Lista de obras - Mikael Elofsson - Dominio Público Uruguay

11 Direct synthesis of glycosylated amino acids from carbohydrate peracetates and Fmoc amino acids: Solid-phase synthesis of biomedicinally interesting glycopeptides

artículo científico publicado el 1 de enero de 1997

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

scientific article published in Nature Communications

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

2-[4,5-Difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2.

artículo científico publicado en 2012

A Potent Trivalent Sialic Acid Inhibitor of Adenovirus Type 37 Infection of Human Corneal Cells

artículo científico publicado en 2011

A fluorinated selenide linker for solid-phase synthesis of n-pentenyl glycosides

scientific article published on 01 December 2004

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

artículo científico publicado en 2006

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound.

artículo científico publicado en 2018

Antiviral Activity of Benzavir-2 against Emerging Flaviviruses

scientific article published on 22 March 2020

Application of gel-phase 19F NMR spectroscopy for optimization of solid-phase synthesis of a hydrophobic peptide from the signal sequence of the mucin MUC1

scientific article published on 01 May 2007

Attenuation of Pseudomonas aeruginosa infection by INP0341, a salicylidene acylhydrazide, in a murine model of keratitis

artículo científico publicado en 2020

Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.

artículo científico publicado en 2014

Building blocks for glycopeptide synthesis: glycosylation of 3-mercaptopropionic acid and Fmoc amino acids with unprotected carboxyl groups

article published in 1991

Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseriagonorrhoeae

artículo científico publicado en 2010

Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13

artículo científico publicado en 2002

Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7.

artículo científico publicado en 2009

Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3

artículo científico publicado en 2013

Corticosteroids protect infected cells against mycobacterial killing in vitro

artículo científico publicado en 2019

Cyclopropylmethyl Protection of Phenols: Total Synthesis of the Resveratrol Dimers Anigopreissin A and Resveratrol-Piceatannol Hybrid

Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens

artículo científico publicado en 2012

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

artículo científico publicado en 2014

Design, synthesis and evaluation of novel polypharmacological antichlamydial agents

artículo científico publicado en 2015

Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis

artículo científico publicado en 2009

Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia

artículo científico publicado en 2007

Development, Optimization, and Validation of a High Throughput Screening Assay for Identification of Tat and Type II Secretion Inhibitors of Pseudomonas aeruginosa

artículo científico publicado en 2019

Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis ⬇️

artículo científico publicado en 2015

Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening

artículo científico publicado en 2012

Diversity-Oriented Synthesis of Libraries Based on Benzofuran and 2,3-Dihydrobenzofuran Scaffolds

artículo científico publicado en 2017

Exploring divalent conjugates of 5-<i>N</i>-acetyl-neuraminic acid as inhibitors of coxsackievirus A24 variant (CVA24v) transduction

artículo científico publicado en 2022

Exploring resveratrol dimers as virulence blocking agents - Attenuation of type III secretion in Yersinia pseudotuberculosis and Pseudomonas aeruginosa

artículo científico publicado en 2020

Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis

artículo científico publicado en 2010

Fluorinated protective groups for on-resin quantification of solid-phase oligosaccharide synthesis with 19F NMR spectroscopy

artículo científico publicado en 2002

Formation of lactones from sialylated MUC1 glycopeptides.

artículo científico publicado en 2006

Gel-phase 19F NMR spectral quality for resins commonly used in solid-phase organic synthesis; a study of peptide solid-phase glycosylations

artículo científico publicado en 2004

Identification and Characterization of Novel Compounds Blocking Shiga Toxin Expression in Escherichia coli O157:H7.

artículo científico publicado en 2016

Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.

artículo científico publicado en 2016

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

artículo científico publicado en 2018

Identification of Small Molecules Blocking the <i>Pseudomonas aeruginosa</i> type III Secretion System Protein PcrV

scientific article published on 04 January 2021

Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo

artículo científico publicado en 2014

Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.

artículo científico

In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds

artículo científico publicado en 2012

Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors

artículo científico publicado en 2007

Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides

artículo científico publicado en 2007

Inhibitory activity of the isoflavone biochanin A on intracellular bacteria of genus Chlamydia and initial development of a buccal formulation

artículo científico publicado en 2014

Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria.

artículo científico publicado en 2014

Loading of the antigen-presenting protein CD1d with synthetic glycolipids.

artículo científico publicado en 2004

Multivalent HSA conjugates of 3'-sialyllactose are potent inhibitors of adenoviral cell attachment and infection

artículo científico publicado en 2005

Multivalent sialic acid conjugates inhibit adenovirus type 37 from binding to and infecting human corneal epithelial cells

artículo científico

Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity

artículo científico publicado en 2013

Mycobacterium tuberculosis virulence inhibitors discovered by Mycobacterium marinum high-throughput screening

scientific article published in Scientific Reports

N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.

artículo científico publicado en 2014

N-acylated derivatives of sulfamethoxazole block Chlamydia fatty acid synthesis and interact with FabF.

artículo científico publicado en 2017

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors.

artículo científico publicado en 2017

NMR tube filter reactor for solid-phase synthesis and gel-phase 19F NMR spectroscopy

scientific article published on 01 March 2006

Natural product inspired library synthesis - Identification of 2,3-diarylbenzofuran and 2,3-dihydrobenzofuran based inhibitors of Chlamydia trachomatis.

artículo científico publicado en 2017

Novel high-throughput screening method for identification of fungal dimorphism blockers

artículo científico publicado en 2014

PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3

artículo científico publicado en 2013

PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers

scientific article published on 15 November 2018

Pentavalent sialic acid conjugates block coxsackievirus A24 variant and human adenovirus type 37 - viruses that cause highly contagious eye infections

artículo científico publicado en 2020

Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion

artículo científico publicado en 2012

Preliminary pharmacokinetics of the bacterial virulence inhibitor n'-(3,5-dibromo-2-hydroxy-benzylidenene)-nicotinic Acid hydrazide

artículo científico publicado en 2012

Protection of mice from a Chlamydia trachomatis vaginal infection using a Salicylidene acylhydrazide, a potential microbicide

artículo científico publicado en 2011

Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.

artículo científico publicado en 2011

Red Fluorescent Applied to Live Cell Imaging and Screening for Antibacterial Agents

scientific article published on 18 December 2018

Removal of Acyl Protective Groups from Glycopeptides: Base Does Not Epimerize Peptide Stereocenters, and beta-Elimination Is Slow

artículo científico publicado en 1996

Reversal of the antichlamydial activity of putative type III secretion inhibitors by iron

artículo científico publicado en 2007

Salicylanilides are potent inhibitors of type III secretion in Yersinia

artículo científico publicado en 2003

Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium

artículo científico publicado en 2007

Screening for Inhibitors of Acetaldehyde Dehydrogenase (AdhE) from Enterohemorrhagic Escherichia coli (EHEC)

artículo científico publicado en 2018

Screening for inhibition of Vibrio cholerae VipA-VipB interaction identifies small-molecule compounds active against type VI secretion.

artículo científico publicado en 2014

Sialic Acid-Containing Glycans as Cellular Receptors for Ocular Human Adenoviruses: Implications for Tropism and Treatment

artículo científico publicado en 2019

Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

artículo científico publicado en 2007

Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis.

artículo científico publicado en 2012

Small-molecule screening using a whole-cell viral replication reporter gene assay identifies 2-{[2-(benzoylamino)benzoyl]amino}-benzoic acid as a novel antiadenoviral compound

artículo científico publicado en 2010

Solid-phase synthesis of alpha-Gal epitopes: on-resin analysis of solid-phase oligosaccharide synthesis with 19F NMR spectroscopy

artículo científico publicado en 2003

Solid-phase synthesis of serine-based glycosphingolipid analogues for preparation of glycoconjugate arrays

artículo científico publicado en 2004

Solving the supply of resveratrol tetramers from Papua New Guinean rainforest anisoptera species that inhibit bacterial type III secretion systems ⬇️

artículo científico publicado en 2014

Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia

artículo científico publicado en 2010

Statistical molecular design: a tool to follow up hits from small-molecule screening

artículo científico publicado en 2014

Structural Characterisation of Tpx from Yersinia pseudotuberculosis Reveals Insights into the Binding of Salicylidene Acylhydrazide Compounds

artículo científico publicado en 2012

Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.

artículo científico publicado en 2017

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

artículo científico publicado en 2015

Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges

artículo científico publicado en 2011

Synthesis and application of N-[1-(4-(4-fluorophenyl)-2,6-dioxocyclohexylidene)ethyl] (Fde)-protected amino acids for optimization of solid-phase peptide synthesis using gel-phase (19)F NMR spectroscopy

artículo científico publicado en 2009

Synthesis and application of a 2-[(4-fluorophenyl)-sulfonyl]ethoxy carbonyl(Fsec) protected glycosyl donor in carbohydrate chemistry.

artículo científico publicado en 2010

Synthesis and evaluation of 2-(2-fluoro-4-hydroxymethyl-5-methoxy-phenoxy)acetic acid as a linker in solid-phase synthesis monitored by gel-phase (19)F NMR spectroscopy

artículo científico publicado en 2007

Synthesis of 2-(2-aminopyrimidine)-2,2-difluoroethanols as potential bioisosters of salicylidene acylhydrazides.

artículo científico publicado en 2010

Synthesis of Indole-, Benzo[ b]thiophene-, and Benzo[ b]selenophene-Based Analogues of the Resveratrol Dimers Viniferifuran and (±)-Dehydroampelopsin B

artículo científico publicado en 2018

Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides.

artículo científico publicado en 2010

Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication

artículo científico publicado en 2012

Targeting bacterial virulence: inhibitors of type III secretion in Yersinia

artículo científico publicado en 2003

The gallium(III)-salicylidene acylhydrazide complex shows synergistic anti-biofilm effect and inhibits toxin production by Pseudomonas aeruginosa.

artículo científico publicado en 2014

The resveratrol tetramer (-)-hopeaphenol inhibits type III secretion in the gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa

artículo científico publicado en 2013

The salicylidene acylhydrazide INP0341 attenuates Pseudomonas aeruginosa virulence in vitro and in vivo

artículo científico publicado en 2017

Total Synthesis of Viniferifuran, Resveratrol-Piceatannol Hybrid, Anigopreissin A and Analogues - Investigation of Demethylation Strategies

artículo científico publicado en 2016

Total Synthesis of the Resveratrol Oligomers (±)‐Ampelopsin B and (±)‐ϵ‐Viniferin.

artículo científico publicado en 2015

Towards small molecule inhibitors of mono-ADP-ribosyltransferases

artículo científico publicado en 2015

Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells

artículo científico publicado en 2015

Type III secretion inhibitors for the management of bacterial plant diseases

scientific article published on 19 October 2018

[Virulence blocking antibiotics. Anti-bacterial agents with completely new action mechanisms]

scientific article published on 01 September 2009

Lista de obras de Mikael Elofsson

11 Direct synthesis of glycosylated amino acids from carbohydrate peracetates and Fmoc amino acids: Solid-phase synthesis of biomedicinally interesting glycopeptides

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

2-[4,5-Difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2.

A Potent Trivalent Sialic Acid Inhibitor of Adenovirus Type 37 Infection of Human Corneal Cells

A fluorinated selenide linker for solid-phase synthesis of n-pentenyl glycosides

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound.

Antiviral Activity of Benzavir-2 against Emerging Flaviviruses

Application of gel-phase 19F NMR spectroscopy for optimization of solid-phase synthesis of a hydrophobic peptide from the signal sequence of the mucin MUC1

Attenuation of Pseudomonas aeruginosa infection by INP0341, a salicylidene acylhydrazide, in a murine model of keratitis

Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.

Building blocks for glycopeptide synthesis: glycosylation of 3-mercaptopropionic acid and Fmoc amino acids with unprotected carboxyl groups

Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseriagonorrhoeae

Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13

Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7.

Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3

Corticosteroids protect infected cells against mycobacterial killing in vitro

Cyclopropylmethyl Protection of Phenols: Total Synthesis of the Resveratrol Dimers Anigopreissin A and Resveratrol-Piceatannol Hybrid

Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

Design, synthesis and evaluation of novel polypharmacological antichlamydial agents

Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis

Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia

Development, Optimization, and Validation of a High Throughput Screening Assay for Identification of Tat and Type II Secretion Inhibitors of Pseudomonas aeruginosa

Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis ⬇️

Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening

Diversity-Oriented Synthesis of Libraries Based on Benzofuran and 2,3-Dihydrobenzofuran Scaffolds

Exploring divalent conjugates of 5-<i>N</i>-acetyl-neuraminic acid as inhibitors of coxsackievirus A24 variant (CVA24v) transduction

Exploring resveratrol dimers as virulence blocking agents - Attenuation of type III secretion in Yersinia pseudotuberculosis and Pseudomonas aeruginosa

Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis

Fluorinated protective groups for on-resin quantification of solid-phase oligosaccharide synthesis with 19F NMR spectroscopy

Formation of lactones from sialylated MUC1 glycopeptides.

Gel-phase 19F NMR spectral quality for resins commonly used in solid-phase organic synthesis; a study of peptide solid-phase glycosylations

Identification and Characterization of Novel Compounds Blocking Shiga Toxin Expression in Escherichia coli O157:H7.

Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

Identification of Small Molecules Blocking the <i>Pseudomonas aeruginosa</i> type III Secretion System Protein PcrV

Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo

Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.

In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds

Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors

Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides

Inhibitory activity of the isoflavone biochanin A on intracellular bacteria of genus Chlamydia and initial development of a buccal formulation

Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria.

Loading of the antigen-presenting protein CD1d with synthetic glycolipids.

Multivalent HSA conjugates of 3'-sialyllactose are potent inhibitors of adenoviral cell attachment and infection

Multivalent sialic acid conjugates inhibit adenovirus type 37 from binding to and infecting human corneal epithelial cells

Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity

Mycobacterium tuberculosis virulence inhibitors discovered by Mycobacterium marinum high-throughput screening

N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.

N-acylated derivatives of sulfamethoxazole block Chlamydia fatty acid synthesis and interact with FabF.

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors.

NMR tube filter reactor for solid-phase synthesis and gel-phase 19F NMR spectroscopy

Natural product inspired library synthesis - Identification of 2,3-diarylbenzofuran and 2,3-dihydrobenzofuran based inhibitors of Chlamydia trachomatis.

Novel high-throughput screening method for identification of fungal dimorphism blockers

PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3

PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers

Pentavalent sialic acid conjugates block coxsackievirus A24 variant and human adenovirus type 37 - viruses that cause highly contagious eye infections

Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion

Preliminary pharmacokinetics of the bacterial virulence inhibitor n'-(3,5-dibromo-2-hydroxy-benzylidenene)-nicotinic Acid hydrazide

Protection of mice from a Chlamydia trachomatis vaginal infection using a Salicylidene acylhydrazide, a potential microbicide

Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.

Red Fluorescent Applied to Live Cell Imaging and Screening for Antibacterial Agents

Removal of Acyl Protective Groups from Glycopeptides: Base Does Not Epimerize Peptide Stereocenters, and beta-Elimination Is Slow

Reversal of the antichlamydial activity of putative type III secretion inhibitors by iron

Salicylanilides are potent inhibitors of type III secretion in Yersinia

Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium

Screening for Inhibitors of Acetaldehyde Dehydrogenase (AdhE) from Enterohemorrhagic Escherichia coli (EHEC)

Screening for inhibition of Vibrio cholerae VipA-VipB interaction identifies small-molecule compounds active against type VI secretion.

Sialic Acid-Containing Glycans as Cellular Receptors for Ocular Human Adenoviruses: Implications for Tropism and Treatment

Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis.

Small-molecule screening using a whole-cell viral replication reporter gene assay identifies 2-{[2-(benzoylamino)benzoyl]amino}-benzoic acid as a novel antiadenoviral compound

Solid-phase synthesis of alpha-Gal epitopes: on-resin analysis of solid-phase oligosaccharide synthesis with 19F NMR spectroscopy

Solid-phase synthesis of serine-based glycosphingolipid analogues for preparation of glycoconjugate arrays

Solving the supply of resveratrol tetramers from Papua New Guinean rainforest anisoptera species that inhibit bacterial type III secretion systems ⬇️

Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia

Statistical molecular design: a tool to follow up hits from small-molecule screening