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Lista de obras de Larry Sklar

A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3',5'-Cyclic Adenosine Monophosphate Efflux

artículo científico publicado en 2016

A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry

article

A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions

scientific article published on 22 June 2020

A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients

artículo científico publicado en 2015

A Pan-GTPase Inhibitor as a Molecular Probe

artículo científico publicado en 2015

A Potent and Selective Inhibitor of Cdc42 GTPase

A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling

scientific article published on 06 November 2019

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition

artículo científico publicado en 2012

A crowdsourcing evaluation of the NIH chemical probes

artículo científico publicado en 2009

A high throughput flow cytometric assay platform targeting transporter inhibition

artículo científico publicado en 2014

A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants

artículo científico publicado en 2014

A miniature Couette to generate shear for flow cytometry: studying real-time modulation of intracellular calcium in monocytic cells

artículo científico publicado en 2011

A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system

artículo científico publicado en 2008

A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6

artículo científico publicado en 2012

A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand

artículo científico publicado en 2009

A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging

artículo científico publicado en 2011

A quantitative approach for studying IgE-FcepsilonRI aggregation

artículo científico publicado en 2002

A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry

artículo científico publicado en 2012

A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

artículo científico publicado en 2005

ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle

artículo científico publicado en 2005

Activation of Rho Family GTPases by Small Molecules.

artículo científico publicado en 2018

Advances in multiple analyte profiling.

artículo científico publicado en 2008

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

artículo científico publicado en 2015

Alpha4beta1 integrin affinity changes govern cell adhesion

artículo científico publicado en 2003

An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicans virulence-related proteins

artículo científico publicado en 2014

An interview with Larry Sklar, Ph.D., and Bruce Edwards, Ph.D. Interview by Vicki Glaser

artículo científico publicado en 2010

An investigation of liquid carryover and sample residual for a high-throughput flow cytometer sample delivery system

artículo científico publicado en 2004

Arrestin Variants Display Differential Binding Characteristics for the PhosphorylatedN-Formyl Peptide Receptor Carboxyl Terminus

artículo científico publicado en 2002

Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion.

artículo científico publicado en 2012

Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.

artículo científico publicado en 2011

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

artículo científico publicado en 2018

Badapple: promiscuity patterns from noisy evidence

artículo científico publicado en 2016

Biomimetic Molecular Assemblies on Glass and Mesoporous Silica Microbeads for Biotechnology†

Biomolecular recognition on well-characterized beads packed in microfluidic channels

scientific article published on 01 March 2002

Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform

Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization

artículo científico publicado en 2014

Chapter 11. Subsecond analyses of G-protein coupled-receptor ternary complex dynamics by rapid mix flow cytometry

artículo científico publicado en 2009

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

artículo científico publicado en 2013

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

artículo científico publicado en 2014

Clioquinol: To harm or heal

scientific article published on 18 March 2019

Cluster cytometry for high-capacity bioanalysis.

artículo científico publicado en 2012

Conformational mAb as a tool for integrin ligand discovery

artículo científico publicado en 2009

Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation

artículo científico publicado en 2004

Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia.

artículo científico publicado en 2016

Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system

artículo científico publicado en 2009

Diazo coupling method for covalent attachment of proteins to solid substrates

artículo científico publicado en 2006

Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

Discovery of Very Late Antigen-4 (VLA-4, α4β1 Integrin) Allosteric Antagonists ⬇️

artículo científico publicado el 3 de diciembre de 2010

Discovery of regulators of receptor internalization with high-throughput flow cytometry

artículo científico publicado en 2012

Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30

artículo científico publicado en 2009

Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships

artículo científico publicado en 2005

Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system

artículo científico publicado en 2007

Drug Repurposing from an Academic Perspective

artículo científico publicado en 2011

Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity

scientific article published on 07 February 2020

Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes

artículo científico publicado en 2009

Duplexed, bead-based competitive assay for inhibitors of protein kinases

artículo científico publicado en 2007

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

scientific article published on 01 February 2020

Dynamics of fluorescence dequenching of ostrich-quenched fluorescein biotin: a multifunctional quantitative assay for biotin

artículo científico publicado en 2005

Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

artículo científico publicado en 2004

Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide

artículo científico publicado en 2009

Erratum: A crowdsourcing evaluation of the NIH chemical probes

article

Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

artículo científico publicado en 2008

Evaluating integrin activation with time-resolved flow cytometry

artículo científico publicado en 2018

FRET detection of cellular alpha4-integrin conformational activation.

artículo científico publicado en 2003

FRET detection of lymphocyte function-associated antigen-1 conformational extension.

artículo científico publicado en 2014

Far away from the lamppost

artículo científico publicado en 2018

Flow Cytometry: Impact on Early Drug Discovery

artículo científico publicado en 2015

Flow cytometric analysis of ligand-receptor interactions and molecular assemblies

artículo científico publicado en 2001

Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis

artículo científico publicado en 2012

Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening

artículo científico publicado en 2007

Flow cytometry for high-throughput, high-content screening

artículo científico publicado en 2004

Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases

artículo científico publicado en 2008

Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters

artículo científico publicado en 2013

Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia

artículo científico publicado en 2018

Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins

artículo científico publicado en 2003

GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone

scientific article published on 17 January 2011

GPR30: A G protein-coupled receptor for estrogen

artículo científico publicado en 2007

GPR30: a novel therapeutic target in estrogen-related disease

artículo científico publicado en 2008

Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion

artículo científico publicado en 2008

Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH.

artículo científico publicado en 2006

High throughput flow cytometry based yeast two-hybrid array approach for large-scale analysis of protein-protein interactions

artículo científico publicado en 2011

High-Throughput Flow Cytometry

High-Throughput Flow Cytometry Drug Combination Discovery with Novel Synergy Analysis Software, SynScreen

scientific article published on 29 May 2018

High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL

article

High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems.

artículo científico publicado en 2018

High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining

article published in 2018

High-content screening: flow cytometry analysis

artículo científico publicado en 2009

High-throughput cytotoxicity screening by propidium iodide staining

artículo científico publicado en 2007

High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors

artículo científico publicado en 2012

High-throughput flow cytometry compatible biosensor based on fluorogen activating protein technology

artículo científico publicado en 2013

High-throughput flow cytometry for drug discovery

artículo científico publicado en 2007

High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters

artículo científico publicado en 2008

High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening

artículo científico publicado en 2004

High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors

artículo científico publicado en 2010

High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry

artículo científico publicado en 2011

High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent

artículo científico publicado en 2008

High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands

artículo científico publicado en 2005

Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

artículo científico publicado en 2010

High‐throughput flow cytometry: Validation in microvolume bioassays ⬇️

artículo científico publicado el 1 de mayo de 2003

Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p

artículo científico publicado en 2009

Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity

artículo científico publicado en 2011

Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay

artículo científico publicado en 2009

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

artículo científico publicado en 2012

Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry

artículo científico publicado en 2009

Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening

artículo científico publicado en 2014

Immobilized stromal cell-derived factor-1alpha triggers rapid VLA-4 affinity increases to stabilize lymphocyte tethers on VCAM-1 and subsequently initiate firm adhesion

artículo científico publicado en 2007

In vivo effects of a GPR30 antagonist

artículo científico publicado en 2009

Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents

artículo científico publicado en 2010

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

artículo científico publicado en 2016

Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins

artículo científico publicado en 2005

Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p).

artículo científico publicado en 2012

Integration of virtual and physical screening

Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists

artículo científico publicado en 2005

Is prolonged stem cell mobilization detrimental for hematopoiesis?

artículo científico publicado en 2011

Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.

artículo científico publicado en 2003

Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates.

artículo científico publicado en 2006

Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide

artículo científico publicado en 2009

Microbial efflux pump inhibition: tactics and strategies

artículo científico publicado en 2011

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

artículo científico publicado en 2006

Microsphere‐Based Flow Cytometry Protease Assays for Use in Protease Activity Detection and High‐Throughput Screening ⬇️

artículo científico publicado el 1 de octubre de 2010

N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity

artículo científico publicado en 2002

Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion

artículo científico publicado en 2011

Novel ABCG2 Antagonists Reverse Topotecan-Mediated Chemotherapeutic Resistance in Ovarian Carcinoma Xenografts

artículo científico publicado en 2016

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

artículo científico publicado en 2015

Nozzle design parameters and their effects on rapid sample delivery in flow cytometry.

artículo científico publicado en 2002

Open, reconfigurable cytometric acquisition system: ORCAS.

artículo científico publicado en 2007

Overview: assays for studying integrin-dependent cell adhesion.

artículo científico

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

artículo científico publicado en 2012

Pharos: Collating protein information to shed light on the druggable genome

artículo científico publicado en 2016

Post-high-throughput screening analysis: an empirical compound prioritization scheme

artículo científico publicado en 2005

Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.

artículo científico publicado en 2008

Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway

artículo científico publicado en 2013

Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

artículo científico publicado en 2020

Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein.

artículo científico publicado en 2015

Quantum Dots for Quantitative Flow Cytometry ⬇️

artículo científico publicado el 1 de enero de 2011

R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis

artículo científico publicado en 2015

Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides

artículo científico publicado en 2007

Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation

artículo científico publicado en 2009

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction

artículo científico publicado en 2004

Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.

artículo científico publicado en 2011

Real-time analysis of very late antigen-4 affinity modulation by shear

artículo científico publicado en 2004

Real-time detection of protein trafficking with high-throughput flow cytometry (HTFC) and fluorogen-activating protein (FAP) base biosensor

artículo científico publicado en 2014

Real-time partitioning of octadecyl rhodamine B into bead-supported lipid bilayer membranes revealing quantitative differences in saturable binding sites in DOPC and 1:1:1 DOPC/SM/cholesterol membranes

artículo científico publicado en 2010

Recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: Toward the development of high-throughput screening flow cytometry assays

artículo científico publicado en 2010

Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin

artículo científico publicado en 2007

Regulation of human basophil adhesion to endothelium under flow conditions: Different very late antigen 4 regulation on umbilical cord blood-derived and peripheral blood basophils.

artículo científico publicado en 2002

Relationship between molecular and cellular dissociation rates for VLA-4/VCAM-1 interaction in the absence of shear stress

artículo científico publicado en 2004

Relationship of light scatter change and Cdc42-regulated actin status.

artículo científico publicado en 2015

Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

artículo científico publicado en 2003

Retraction Notice to: ATP Hydrolysis-Dependent Disassembly of the 26S Proteasome Is Part of the Catalytic Cycle

artículo científico publicado en 2018

Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3.

artículo científico publicado en 2006

Selective Bcl-2 Inhibitor Probes

artículo científico publicado en 2013

Selective Efflux Inhibition of ATP-binding Cassette Sub-family G Member 2

artículo científico publicado en 2013

Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries

artículo científico publicado en 2013

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance

artículo científico publicado en 2014

Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples.

artículo científico publicado en 2011

Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus

artículo científico publicado en 2014

Small-volume rapid-mix device for subsecond kinetic analysis in flow cytometry

artículo científico publicado en 2005

Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads

artículo científico publicado en 2007

Spectroscopic characterization of streptavidin functionalized quantum dots

artículo científico publicado en 2007

Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands

artículo científico

Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.

artículo científico publicado en 2010

Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.

artículo científico publicado en 2007

TIN-X: target importance and novelty explorer

artículo científico

Targeting efflux pumps to overcome antifungal drug resistance

artículo científico publicado en 2016

Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy

artículo científico publicado en 2012

Techniques: GPCR assembly, pharmacology and screening by flow cytometry.

artículo científico publicado en 2004

The University of New Mexico Center for Molecular Discovery

artículo científico publicado en 2014

The development of quantum dot calibration beads and quantitative multicolor bioassays in flow cytometry and microscopy

artículo científico publicado en 2007

The evaluation of thioridazine as a hematopoietic progenitor cell mobilizing agent in healthy human subjects

artículo científico publicado en 2015

The ins and outs of GPR30: a transmembrane estrogen receptor

artículo científico publicado en 2008

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates

artículo científico publicado en 2011

The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures.

artículo científico publicado en 2011

Three small molecule pan activator families of Ras-related GTPases

Unexplored therapeutic opportunities in the human genome

scientific article published on 23 March 2018

Unexplored therapeutic opportunities in the human genome.

artículo científico publicado en 2018

Virtual and <i>In Vitro</i> Antiviral Screening Revive Therapeutic Drugs for COVID-19

artículo científico publicado en 2020

Virtual and biomolecular screening converge on a selective agonist for GPR30.

artículo científico publicado en 2006

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