Lista de obras - John G Doench - Dominio Público Uruguay

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels

scientific article published on 13 June 2019

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

article

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

artículo científico publicado en 2019

A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion

artículo científico publicado en 2018

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

artículo científico publicado en 2019

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

artículo científico publicado en 2016

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

artículo científico publicado en 2017

A case of mistaken identity

artículo científico publicado en 2018

A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition

artículo científico publicado en 2022

A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing

artículo científico publicado en 2018

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

artículo científico publicado en 2019

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

scientific article published on 26 May 2020

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

artículo científico publicado en 2015

Am I ready for CRISPR? A user's guide to genetic screens

artículo científico publicado en 2017

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

scientific article published on 30 July 2018

Analysis of microRNA effector functions in vitro

artículo científico publicado en 2007

Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations

artículo científico publicado en 2020

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

scientific article published on 25 July 2019

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

artículo científico publicado en 2022

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

artículo científico publicado en 2016

CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.

artículo científico publicado en 2018

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

artículo científico publicado en 2020

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

scientific article published on 29 November 2019

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

artículo científico publicado en 2019

CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors

artículo científico publicado en 2017

CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation

artículo científico publicado en 2019

CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity

artículo científico publicado en 2016

CRISPR/Cas9 gene editing special issue

artículo científico publicado en 2016

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

scientific article published on 18 May 2020

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

artículo científico publicado en 2021

Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

artículo científico publicado en 2022

Comparison of siRNA-induced off-target RNA and protein effects

artículo científico publicado en 2007

Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

artículo científico publicado en 2020

Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

artículo científico publicado en 2017

Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

artículo científico publicado en 2017

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

artículo científico publicado en 2017

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

scientific article published on 17 February 2020

DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression

scientific article published on 18 May 2020

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

artículo científico publicado en 2015

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells

artículo científico publicado en 2018

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

artículo científico

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

artículo científico publicado en 2020

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

artículo científico publicado en 2017

Design and analysis of CRISPR-Cas experiments

artículo científico publicado en 2020

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

scientific article published on 21 February 2019

Discovering metabolic disease gene interactions by correlated effects on cellular morphology

article

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

artículo científico publicado en 2020

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

artículo científico publicado en 2013

Discovery of a proteinaceous cellular receptor for a norovirus

artículo científico publicado en 2016

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

artículo científico publicado en 2021

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

artículo científico publicado en 2017

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

artículo científico publicado en 2015

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

artículo científico publicado en 2017

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

artículo científico publicado en 2019

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

artículo científico publicado en 2016

Genetic screens and functional genomics using CRISPR/Cas9 technology

artículo científico publicado en 2015

Genetic screens in isogenic mammalian cell lines without single cell cloning

artículo científico publicado en 2020

Genome-scale CRISPR-Cas9 knockout screening in human cells

artículo científico publicado en 2014

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

artículo científico publicado en 2020

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

artículo científico publicado en 2020

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

scientific article published on 17 June 2020

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

scientific article published on 24 January 2020

HDAC5 controls MEF2C-driven sclerostin expression in osteocytes

artículo científico publicado en 2015

High-throughput Phenotyping of Lung Cancer Somatic Mutations

artículo científico publicado en 2016

High-throughput Phenotyping of Lung Cancer Somatic Mutations

artículo científico publicado en 2017

IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening.

artículo científico publicado en 2018

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach

artículo científico publicado en 2012

Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

scientific article published on 01 September 2020

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

artículo científico publicado en 2017

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

artículo científico publicado en 2022

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency

artículo científico publicado en 2015

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

artículo científico publicado en 2020

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

artículo científico publicado en 2017

Kinase requirements in human cells: I. Comparing kinase requirements across various cell types

artículo científico publicado en 2008

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

artículo científico publicado en 2018

MEN1 mutations mediate clinical resistance to menin inhibition

scientific article published on 15 March 2023

MYC Controls the Epstein-Barr Virus Lytic Switch

artículo científico publicado en 2020

Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion ⬇️

artículo científico publicado en 2015

Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

artículo científico publicado en 2020

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

scientific article published on 19 September 2019

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

artículo científico publicado en 2015

Mutational processes shape the landscape of TP53 mutations in human cancer.

artículo científico publicado en 2018

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

artículo científico

Natural variation in arsenic toxicity is explained by differences in branched chain amino acid catabolism

article

Natural variation in arsenic toxicity is explained by differences in branched chain amino acid metabolism

article

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes

artículo científico publicado en 2018

Optimization of AsCas12a for combinatorial genetic screens in human cells

artículo científico publicado en 2020

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

artículo científico publicado en 2018

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

artículo científico publicado en 2016

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.

artículo científico publicado en 2017

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

artículo científico publicado en 2017

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

artículo científico publicado en 2018

Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs

artículo científico publicado en 2018

Progression signature underlies clonal evolution and dissemination of multiple myeloma

artículo científico publicado en 2020

RNA interference of Xenopus NMDAR NR1 in vitro and in vivo

artículo científico publicado en 2005

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

artículo científico publicado en 2014

Recapitulation of short RNA-directed translational gene silencing in vitro

article

Reduced expression of ribosomal proteins relieves microRNA-mediated repression.

artículo científico publicado en 2012

SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas

artículo científico publicado en 2013

Specificity of microRNA target selection in translational repression

artículo científico publicado en 2004

Synergistic interactions with PI3K inhibition that induce apoptosis.

artículo científico publicado en 2017

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

artículo científico publicado en 2016

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

artículo científico publicado en 2014

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

scientific article published on 11 December 2019

The Canonical Wnt Pathway Drives Macropinocytosis in Cancer

artículo científico publicado en 2018

UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages

artículo científico publicado en 2021

Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens.

artículo científico publicado en 2018

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential

scientific article published on 11 July 2018

siRNAs can function as miRNAs

artículo científico publicado en 2003

Lista de obras de John G Doench

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

A case of mistaken identity

A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition

A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

Am I ready for CRISPR? A user's guide to genetic screens

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

Analysis of microRNA effector functions in vitro

Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors

CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation

CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity

CRISPR/Cas9 gene editing special issue

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

Comparison of siRNA-induced off-target RNA and protein effects

Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Design and analysis of CRISPR-Cas experiments

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

Discovering metabolic disease gene interactions by correlated effects on cellular morphology

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

Discovery of a proteinaceous cellular receptor for a norovirus

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

Genetic screens and functional genomics using CRISPR/Cas9 technology

Genetic screens in isogenic mammalian cell lines without single cell cloning

Genome-scale CRISPR-Cas9 knockout screening in human cells

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

HDAC5 controls MEF2C-driven sclerostin expression in osteocytes

High-throughput Phenotyping of Lung Cancer Somatic Mutations

High-throughput Phenotyping of Lung Cancer Somatic Mutations

IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening.

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach

Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

Kinase requirements in human cells: I. Comparing kinase requirements across various cell types

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

MEN1 mutations mediate clinical resistance to menin inhibition