Lista de obras - Charles P Hart - Dominio Público Uruguay

14-Aminocamptothecins: Their Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment ⬇️

artículo científico publicado el 22 de febrero de 2011

A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.

artículo científico publicado en 2007

ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation.

artículo científico publicado en 2007

Activity of the hypoxia-activated prodrug, TH-302, in preclinical human acute myeloid leukemia models.

artículo científico publicado en 2013

Cognate homeo-box loci mapped on homologous human and mouse chromosomes

artículo científico publicado en 1986

Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models

artículo científico publicado en 2015

Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models.

artículo científico publicado en 2016

DD-02PHARMACODYNAMIC BIOMARKER ASSESSMENTS IN A PHASE I/II TRIAL OF THE HYPOXIA-ACTIVATED PRODRUG TH-302 AND BEVACIZUMAB IN BEVACIZUMAB-REFRACTORY RECURRENT GLIOBLASTOMA

artículo científico publicado en 2014

Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer

artículo científico publicado en 2015

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

artículo científico publicado en 2015

Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer

artículo científico publicado en 2014

Genetic Recombination as a Reporter for Screening Steroid Receptor Agonists and Antagonists ⬇️

artículo científico publicado el 10 de abril de 1998

Genetic linkage analysis of the murine developmental mutant velvet coat (Ve) and the distal chromosome 15 developmental genes Hox-3.1, Rar-g, Wnt-1, and Krt-2

artículo científico publicado el 1 de agosto de 1992

Homeo box genes in murine development.

artículo científico publicado en 1987

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

artículo científico publicado el 29 de octubre de 1992

Hypoxia Imaging With PET Correlates With Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma Models.

artículo científico publicado en 2016

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features ⬇️

artículo científico publicado el 6 de marzo de 2012

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

artículo científico publicado en 2015

Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas

artículo científico publicado en 2015

MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts

artículo científico publicado en 2016

Mammalian homeo box genes

scientific article published on 01 January 1985

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

artículo científico publicado en 2011

Molecular cloning and chromosome assignment of murine N-ras

artículo científico publicado en 1984

Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.

artículo científico publicado en 1984

Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

artículo científico publicado en 2016

Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.

artículo científico publicado en 2008

Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.

artículo científico publicado en 2016

Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

artículo científico publicado en 2014

Reproducible subcellular alterations in hepatocytes resulting from ultrasound

scientific article published on 01 January 1980

Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer.

artículo científico publicado en 2011

Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons.

artículo científico publicado en 1987

Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.

artículo científico publicado en 1986

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging.

artículo científico publicado en 2015

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules.

artículo científico publicado en 2012

Lista de obras de Charles P Hart

14-Aminocamptothecins: Their Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment ⬇️

A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.

ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation.

Activity of the hypoxia-activated prodrug, TH-302, in preclinical human acute myeloid leukemia models.

Cognate homeo-box loci mapped on homologous human and mouse chromosomes

Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models

Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models.

DD-02PHARMACODYNAMIC BIOMARKER ASSESSMENTS IN A PHASE I/II TRIAL OF THE HYPOXIA-ACTIVATED PRODRUG TH-302 AND BEVACIZUMAB IN BEVACIZUMAB-REFRACTORY RECURRENT GLIOBLASTOMA

Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer

Genetic Recombination as a Reporter for Screening Steroid Receptor Agonists and Antagonists ⬇️

Genetic linkage analysis of the murine developmental mutant velvet coat (Ve) and the distal chromosome 15 developmental genes Hox-3.1, Rar-g, Wnt-1, and Krt-2

Homeo box genes in murine development.

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

Hypoxia Imaging With PET Correlates With Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma Models.

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features ⬇️

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas

MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts

Mammalian homeo box genes

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

Molecular cloning and chromosome assignment of murine N-ras

Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.

Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.

Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.

Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

Reproducible subcellular alterations in hepatocytes resulting from ultrasound

Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer.

Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons.

Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging.

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules.