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'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing

artículo científico publicado en 2018

A new experimental polytrauma model in rats: molecular characterization of the early inflammatory response

artículo científico publicado en 2012

A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsis

artículo científico publicado en 2013

A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages

artículo científico publicado en 2013

Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury

artículo científico publicado en 2017

Acute lung injury induced by lipopolysaccharide is independent of complement activation

artículo científico publicado en 2008

Adrenergic regulation of complement-induced acute lung injury

artículo científico publicado en 2008

Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils

artículo científico publicado en 2007

Alteration of complement hemolytic activity in different trauma and sepsis models

artículo científico publicado en 2012

Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis

artículo científico publicado en 2002

Anti-complement Strategies in Experimental Sepsis ⬇️

artículo científico publicado el 1 de enero de 2003

Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury ⬇️

artículo científico publicado el 1 de marzo de 2013

Association of Kidney Tissue Barrier Disrupture and Renal Dysfunction in Resuscitated Murine Septic Shock

artículo científico publicado en 2016

Association of adiponectin levels and insulin demand in critically ill patients ⬇️

artículo científico publicado el 26 de enero de 2011

Association of child maltreatment subtypes and long-term physical health in a German representative sample

article

Associations of adverse childhood experiences and bullying on physical pain in the general population of Germany

article

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development

artículo científico publicado en 2019

Author Correction: A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing.

artículo científico publicado en 2018

Autophagy and ATP-induced anti-apoptosis in antigen presenting cells (APC) follows the cytokine storm in patients after major trauma ⬇️

artículo científico publicado el 13 de enero de 2011

Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions

artículo científico publicado en 2017

Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100% O2.

artículo científico publicado en 2015

Bride and groom in systemic inflammation – The bells ring for complement and Toll in cooperation ⬇️

artículo científico publicado el 1 de noviembre de 2012

C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing

scientific article published on 26 October 2016

C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing

artículo científico publicado en 2011

C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10

scholarly article by Yvonne Mödinger et al published December 2018 in Journal of Cellular and Molecular Medicine

Cardiac and metabolic effects of hypothermia and inhaled hydrogen sulfide in anesthetized and ventilated mice

artículo científico publicado en 2010

Catecholamines and the septic heart: opening Pandora's box?

artículo científico publicado en 2013

Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box?

artículo científico publicado en 2008

Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro.

artículo científico publicado en 2012

Challenge to the Intestinal Mucosa During Sepsis

Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans ⬇️

artículo científico publicado el 11 de marzo de 2013

Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans

artículo científico publicado en 2005

Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.

artículo científico publicado en 2019

Combined hemorrhage/trauma models in pigs-current state and future perspectives

artículo científico

Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis

artículo científico publicado en 2015

Complement After Trauma: Suturing Innate and Adaptive Immunity

Complement C3 and C5 deficiency affects fracture healing

artículo científico publicado en 2013

Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β.

artículo científico publicado en 2011

Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock.

artículo científico publicado en 2018

Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects

artículo científico publicado en 2017

Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation

artículo científico publicado en 2017

Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro

artículo científico publicado en 2016

Complement in Human Disease ⬇️

artículo científico publicado el 17 de enero de 2013

Complement in Pancreatic Disease-Perpetrator or Savior?

artículo científico publicado en 2017

Complement in Sepsis - when Science meets Clinics

artículo científico publicado en 2020

Complement in lung disease

artículo científico publicado en 2006

Complement involvement in bone homeostasis and bone disorders

artículo científico publicado en 2018

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

artículo científico publicado en 2017

Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation - closing Pandora's box?

artículo científico publicado en 2016

Complement-coagulation crosstalk on cellular and artificial surfaces

artículo científico publicado en 2016

Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction

artículo científico publicado en 2017

Complement-induced activation of the cardiac NLRP3 inflammasome in sepsis

artículo científico publicado en 2016

Complement-induced impairment of innate immunity during sepsis

artículo científico publicado en 2002

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

artículo científico publicado en 2015

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F Osuchowski et al published October 2018 in Infection

Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

scientific article published on 03 May 2019

Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways

artículo científico publicado en 2009

Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma

artículo científico publicado en 2015

Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

artículo científico publicado en 2016

Deceleration during 'real life' motor vehicle collisions - a sensitive predictor for the risk of sustaining a cervical spine injury?

artículo científico publicado en 2009

Designed azolopyridinium salts block protective antigen pores in vitro and protect cells from anthrax toxin

artículo científico publicado en 2013

Diet-Induced Obesity Affects Muscle Regeneration After Murine Blunt Muscle Trauma-A Broad Spectrum Analysis.

artículo científico publicado en 2018

Different patient case mix by applying the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions instead of the 1992 ACCP/SCCM sepsis definitions in surgical patients: a retrospective observational study

artículo científico publicado en 2009

Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis ⬇️

artículo científico publicado el 30 de diciembre de 2011

Does complement play a role in bone development and regeneration?

artículo científico

Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice

artículo científico publicado en 2014

Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma

artículo científico publicado en 2015

Early complementopathy after multiple injuries in humans

artículo científico publicado en 2012

Early structural changes of the heart after experimental polytrauma and hemorrhagic shock

artículo científico publicado en 2017

Effects and sustainability of trainings for the oral and practical part of the German final exam in medicine

artículo científico publicado en 2013

Effects of Prior Psychosocial Trauma on Subsequent Immune Response After Experimental Thorax Trauma

artículo científico

Effects of intrarenal administration of the calcium antagonist nimodipine during porcine aortic occlusion-induced ischemia/reperfusion injury

artículo científico publicado en 2008

Effects of intrarenal administration of the cox-2 inhibitor parecoxib during porcine suprarenal aortic cross-clamping

artículo científico publicado en 2005

Epinephrine kinetics in septic shock--a means to understand variable catecholamine efficiency?

artículo científico publicado en 2009

Erratum to: Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis

artículo científico publicado en 2016

Evaluation of Gut-Blood Barrier (GBB) dysfunction in various models of trauma, haemorrhagic shock and burn injury

artículo científico publicado en 2017

Experimental blunt chest trauma-induced myocardial inflammation and alteration of gap-junction protein connexin 43.

artículo científico publicado en 2017

Expression and function of the C5a receptor in rat alveolar epithelial cells

scientific journal article

Extracellular Vesicles: Packages Sent With Complement

artículo científico publicado en 2018

Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a.

artículo científico publicado en 2012

Functional immune monitoring in severely injured patients-A pilot study

scientific article published on 03 November 2019

Functional roles for C5a receptors in sepsis

artículo científico publicado en 2008

Functions of the complement components C3 and C5 during sepsis

artículo científico publicado en 2008

Generation of C5a by phagocytic cells

artículo científico publicado en 2002

Generation of murine sympathoadrenergic progenitor-like cells from embryonic stem cells and postnatal adrenal glands

artículo científico publicado en 2013

Granzyme B: a new crossroad of complement and apoptosis

artículo científico

Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma

artículo científico publicado en 2017

How do German medical students perceive role models during clinical placements ("Famulatur")? An empirical study.

artículo científico publicado en 2019

How many general and inflammatory variables need to be fulfilled when defining sepsis due to the 2003 SCCM/ESICM/ACCP/ATS/SIS definitions in critically ill surgical patients: a retrospective observational study ⬇️

artículo científico publicado el 21 de diciembre de 2010

How to treat esophageal perforations when determinants and predictors of mortality are considered

artículo científico publicado en 2009

Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells

artículo científico publicado en 2008

Hypercapnic Conditions After Experimental Blunt Chest Trauma Increase Efferocytosis of Alveolar Macrophages and Reduce Local Inflammation

artículo científico publicado en 2016

Hyperoxia in Septic Shock: Crafty Therapeutic Weapon or Double-Edged Sword?

artículo científico publicado en 2017

IKK2/NF-κB signaling protects neurons after traumatic brain injury

artículo científico publicado en 2017

IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration

artículo científico publicado en 2015

Immunodesign of experimental sepsis by cecal ligation and puncture

scientific article published on January 2009

Immunopathophysiology of trauma-related acute kidney injury

scientific article published on 21 September 2020

Immunostimulatory functions of adoptively transferred MDSCs in experimental blunt chest trauma.

artículo científico publicado en 2019

In-Depth Characterization of the Effects of Cigarette Smoke Exposure on the Acute Trauma Response and Hemorrhage in Mice

artículo científico publicado en 2018

Inflammatory Effects of Hypothermia and Inhaled H2S During Resuscitated, Hyperdynamic Murine Septic Shock ⬇️

artículo científico publicado el 1 de abril de 2011

Inflammatory and apoptotic alterations in serum and injured tissue after experimental polytrauma in mice: distinct early response compared with single trauma or "double-hit" injury

artículo científico publicado en 2013

Inhaled Hydrogen Sulfide Induces Suspended Animation, But Does Not Alter the Inflammatory Response After Blunt Chest Trauma ⬇️

artículo científico publicado el 1 de febrero de 2012

Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis

artículo científico publicado en 2009

Innate immune responses to trauma

artículo científico publicado en 2018

Interaction between the coagulation and complement system

artículo científico publicado en 2008

Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis

artículo científico publicado en 2016

MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses

artículo científico publicado en 2017

Medusa's Head: The Complement System in Traumatic Brain and Spinal Cord Injury

artículo científico publicado en 2017

Mesenchymal Stem Cells after Polytrauma: Actor and Target

artículo científico publicado en 2016

Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release

artículo científico publicado en 2008

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F. Osuchowski et al published 14 August 2018 in Infection

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

Modeling traumatic-hemorrhagic shock--nothing is simple and easy

artículo científico publicado en 2012

Molecular events in the cardiomyopathy of sepsis

artículo científico publicado en 2008

Molecular intercommunication between the complement and coagulation systems

artículo científico publicado en 2010

Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"? ⬇️

artículo científico publicado el 30 de noviembre de 2011

Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses

artículo científico publicado en 2018

Neutrophil heterogeneity and its role in infectious complications after severe trauma.

artículo científico publicado en 2019

Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin.

artículo científico publicado en 2018

New Insights into the Role of Peroxisome Proliferator-Activated Receptors in Regulating the Inflammatory Response after Tissue Injury ⬇️

artículo científico publicado el 29 de febrero de 2012

New insights of an old defense system: structure, function, and clinical relevance of the complement system

artículo científico publicado en 2010

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing

artículo científico publicado en 2017

Oxygen in the Heart: How Much is too Much?

artículo científico publicado en 2016

Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system

artículo científico publicado en 2013

PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma.

artículo científico publicado en 2018

Pathophysiology of septic encephalopathy--an unsolved puzzle

artículo científico publicado en 2010

Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock ⬇️

artículo científico publicado el 12 de enero de 2011

Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma

artículo científico publicado en 2015

Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock

Pyrosequencing-based strategy for a successful SNP detection in two hypervariable regions: HV-I/HV-II of the human mitochondrial displacement loop

artículo científico publicado en 2010

Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation

artículo científico publicado en 2006

Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease?

artículo científico publicado en 2017

Relationship of acute lung inflammatory injury to Fas/FasL system

artículo científico publicado en 2005

Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo

artículo científico publicado en 2017

Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI).

artículo científico publicado en 2016

Role of Complement in Multiorgan Failure ⬇️

artículo científico publicado el 20 de diciembre de 2012

Role of Complement on Broken Surfaces After Trauma

artículo científico

Role of Hemorrhagic Shock in Experimental Polytrauma

artículo científico publicado en 2017

Role of alveolar macrophages in the inflammatory response after trauma

artículo científico

Role of extracellular histones in the cardiomyopathy of sepsis.

artículo científico publicado en 2015

Role of the Purinergic Receptor P2XR4 After Blunt Chest Trauma in Cigarette Smoke-Exposed Mice

artículo científico publicado en 2016

Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients

artículo científico publicado en 2010

Sepsis-Induced Adipokine Change with regard to Insulin Resistance ⬇️

artículo científico publicado el 9 de enero de 2012

Structure-function relationships of human C5a and C5aR.

artículo científico publicado en 2003

Systemic recovery and therapeutic effects of transplanted allogenic and xenogenic mesenchymal stromal cells in a rat blunt chest trauma model

artículo científico publicado en 2017

Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option?

artículo científico publicado en 2019

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

Temperature and cell-type dependency of sulfide effects on mitochondrial respiration

artículo científico publicado en 2012

The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock.

artículo científico publicado en 2019

The Role of Cystathionine-γ-Lyase In Blunt Chest Trauma in Cigarette Smoke Exposed Mice

artículo científico publicado en 2016

The Role of Troponin in Blunt Cardiac Injury After Multiple Trauma in Humans

artículo científico publicado en 2016

The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro

artículo científico publicado en 2011

The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis

scientific journal article

The dual role of academic surgeons as clinicians and researchers - an attempt to square the circle?

artículo científico publicado en 2011

The immune response after fracture trauma is different in old compared to young patients

artículo científico publicado en 2014

The impact of a dedicated training program for oral examiners at a medical school in Germany: a survey among participants from operative and non-operative disciplines ⬇️

artículo científico publicado el 3 de julio de 2013

The molecular fingerprint of lung inflammation after blunt chest trauma

artículo científico publicado en 2015

The neuroprotective effect of ethanol intoxication in TBI is associated with the suppression of ErbB signaling in PV-positive interneurons.

artículo científico publicado en 2018

The obesity paradox revisited: does increased body mass protect against circulatory shock?

artículo científico publicado en 2014

The role of complement in bone healing: Fracture healing in C3 and C5-deficient mice

scholarly article by Christian M. Ehrnthaller et al published November 2012 in Immunobiology

The role of complement in trauma and fracture healing

artículo científico

The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome

artículo científico publicado en 2006

Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure

Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis

artículo científico publicado en 2020

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

artículo científico publicado en 2017

Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response

artículo científico publicado en 2009

Visions and reality: the idea of competence-oriented assessment for German medical students is not yet realised in licensing examinations

artículo científico publicado en 2017

Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system ⬇️

artículo científico publicado el 5 de abril de 2013

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