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A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?

artículo científico publicado en 2016

Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells

artículo científico publicado en 2018

Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure

artículo científico publicado en 2014

Clinical staging: a necessary step in the development of improved animal models of mood disturbance?

artículo científico publicado en 2013

Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus

artículo científico publicado el 28 de mayo de 2012

Cocaine- and Amphetamine-Regulated Transcript (CART) Signaling within the Paraventricular Thalamus Modulates Cocaine-Seeking Behaviour

artículo científico publicado el 23 de septiembre de 2010

Commentary: "Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity".

artículo científico publicado en 2015

Cued Reinstatement of Cocaine but Not Sucrose Seeking Is Dependent on Dopamine Signaling in Prelimbic Cortex and Is Associated with Recruitment of Prelimbic Neurons That Project to Contralateral Nucleus Accumbens Core.

artículo científico publicado en 2017

Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin/hypocretin-1 receptor antagonist in rats

artículo científico publicado en 2018

Differential roles of medial prefrontal subregions in the regulation of drug seeking.

artículo científico publicado en 2014

Do striatal push/pull circuits hold the key to compulsive, relapsing heroin addiction? : A Research Highlight on: Chemogenetic modulation of accumbens direct or indirect pathways bidirectionally alters reinstatement of heroin-seeking in high- but no

scientific article published on 23 January 2020

Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART).

artículo científico publicado en 2014

Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats

artículo científico publicado en 2014

Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats

scientific article published on 07 August 2018

Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system

scientific article published on 14 August 2020

Motivational activation: a unifying hypothesis of orexin/hypocretin function

artículo científico publicado en 2014

New directions for the treatment of depression: Targeting the photic regulation of arousal and mood (PRAM) pathway

artículo científico publicado en 2017

Novelty preference does not predict trait cocaine behaviors in male rats

artículo científico publicado en 2022

Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls

artículo científico publicado en 2014

Orexin-1 Receptor Signaling in Ventral Pallidum Regulates Motivation for the Opioid Remifentanil

artículo científico publicado en 2019

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking.

artículo científico publicado en 2011

Orexin/Hypocretin, Central Amygdala, and Escalation of Cocaine Intake.

artículo científico publicado en 2017

Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner

artículo científico publicado en 2016

Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.

artículo científico publicado en 2016

Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil

scientific article published on 14 September 2019

Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking

artículo científico publicado en 2016

Propensity to 'relapse' following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei.

artículo científico publicado en 2011

Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum.

artículo científico publicado en 2016

Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: why sleep on this any longer?

scientific article published on 27 January 2020

Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders.

artículo científico publicado en 2017

Temporally specific miRNA expression patterns in the dorsal and ventral striatum of addiction-prone rats.

artículo científico publicado en 2017

The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse.

artículo científico publicado en 2016

The number of lateral hypothalamus orexin/hypocretin neurons contributes to individual differences in cocaine demand

artículo científico publicado en 2019

The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task

artículo científico publicado en 2019

The role of orexin-1 receptor signaling in demand for the opioid fentanyl

artículo científico publicado en 2019

What about me…? The PVT: a role for the paraventricular thalamus (PVT) in drug-seeking behavior

artículo científico publicado el 6 de marzo de 2013

mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels.

artículo científico publicado en 2014