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2473 Cardiac injury due to Streptococcus pneumoniae invasion during severe pneumococcal pneumonia in a novel nonhuman primate model

: Invasion and Inflammation

scholarly article by Allister J Loughran et al published March 2019 in Microbiology Spectrum

A Non-Human Primate Model of Severe Pneumococcal Pneumonia

artículo científico publicado en 2016

A role for glycosylated serine‐rich repeat proteins in Gram‐positive bacterial pathogenesis

artículo científico publicado el 11 de junio de 2012

Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia

artículo científico publicado en 2009

Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia

artículo científico publicado en 2012

An in vivo atlas of host-pathogen transcriptomes during <i>Streptococcus pneumoniae</i> colonization and disease

artículo científico publicado en 2020

Anatomical Site-Specific Carbohydrate Availability Impacts Streptococcus pneumoniae Virulence and Fitness during Colonization and Disease

scientific article published in 2022

Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge

artículo científico publicado en 2008

Assessment of molecular typing methods to determine invasiveness and to differentiate clones of Streptococcus pneumoniae

artículo científico publicado en 2007

Bacterial Interactions with Mucosal Epithelial Cells

Bacterial Interactions with Mucosal Epithelial Cells

Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia.

artículo científico publicado en 2018

Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera

artículo científico publicado en 2011

CD8(+) T cells specific to a single Yersinia pseudotuberculosis epitope restrict bacterial replication in the liver but fail to provide sterilizing immunity

artículo científico publicado en 2016

Can animal models really teach us anything about pneumonia? Pro

artículo científico publicado en 2020

Cardiotoxicity during invasive pneumococcal disease

artículo científico publicado en 2015

Cell invasion and pyruvate oxidase derived H2O2 are critical for Streptococcus pneumoniae mediated cardiomyocyte killing.

artículo científico publicado en 2017

Cell wall-mediated neuronal damage in early sepsis

artículo científico publicado en 2006

Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

artículo científico publicado en 2011

Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence

artículo científico publicado en 2011

Chromogranin A levels and mortality in patients with severe sepsis

artículo científico publicado en 2015

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

article

Dysregulated inflammation as a risk factor for pneumonia in the elderly

artículo científico publicado el 1 de diciembre de 2011

Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae

artículo científico publicado en 2010

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs

scientific article published on 17 January 2014

Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma

artículo científico publicado en 2009

Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis.

artículo científico publicado en 2016

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

artículo científico publicado en 2012

Future research directions in pneumonia: NHLBI working group report

artículo científico publicado en 2018

High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis

artículo científico publicado en 2017

Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease

artículo científico publicado en 2006

Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia

artículo científico publicado en 2012

In Vitro Adhesion, Invasion, and Transcytosis of Streptococcus pneumoniae with Host Cells

scientific article published on 01 January 2019

Incidence of cardiovascular events after hospital admission for pneumonia.

artículo científico publicado en 2011

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion

artículo científico publicado en 2016

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis

artículo científico publicado en 2020

Interaction between Streptococcus pneumoniae and Staphylococcus aureus Generates ·OH Radicals That Rapidly Kill Staphylococcus aureus Strains

artículo científico publicado en 2019

Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis

artículo científico publicado en 2013

Killing of Serratia marcescens biofilms with chloramphenicol.

artículo científico publicado en 2017

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

artículo científico publicado en 2009

Major Adverse Cardiovascular Events During Invasive Pneumococcal Disease are Serotype Dependent

scientific article published on 22 September 2020

Microarray analysis of pneumococcal gene expression during invasive disease

artículo científico publicado en 2004

Models of pneumococcal disease

NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis

scientific article published on 01 July 2018

Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease

artículo científico publicado en 2020

Necroptotic Cell Death Promotes Adaptive Immunity Against Colonizing Pneumococci

artículo científico publicado en 2019

Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.

artículo científico publicado en 2016

Noninvasive monitoring of pneumococcal meningitis and evaluation of treatment efficacy in an experimental mouse model.

artículo científico publicado en 2005

Omega-3 fatty acids in contrast to omega-6 protect against pneumococcal pneumonia

scientific article published on 16 January 2020

Opening the OPK Assay Gatekeeper: Harnessing Multi-Modal Protection by Pneumococcal Vaccines

artículo científico publicado en 2019

Organ-specific models of Streptococcus pneumoniae disease

artículo científico publicado en 2003

Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.

artículo científico publicado en 2006

Pneumococcal gene complex involved in resistance to extracellular oxidative stress

artículo científico publicado en 2012

Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix.

artículo científico publicado en 2010

Pneumococci Can Become Virulent by Acquiring a New Capsule From Oral Streptococci

scientific article published on 07 September 2019

Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization

artículo científico publicado en 2014

Pneumococci: immunology of the innate host response.

artículo científico publicado en 2010

Poor Man’s Dot-Blot Apparatus

artículo científico publicado el 1 de diciembre de 1997

Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F.

artículo científico publicado en 2017

Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.

artículo científico publicado en 2012

PsrP, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal type

artículo científico publicado en 2010

Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence

artículo científico publicado en 2007

Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia

artículo científico publicado en 2014

Role played by psrP-secY2A2 (accessory region 34) in the invasive disease potential of Streptococcus pneumoniae

scientific article published on 01 October 2009

Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.

artículo científico publicado en 2017

Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent

scientific article published in PLoS ONE

Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease

artículo científico publicado en 2010

Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization

artículo científico publicado en 2013

Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production

artículo científico publicado en 2011

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

artículo científico

Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function

artículo científico publicado en 2014

Streptococcus pneumoniae: Invasion and Inflammation

scholarly article

Streptococcus pneumoniaePstS Production Is Phosphate Responsive and Enhanced during Growth in the Murine Peritoneal Cavity

artículo científico publicado el 1 de diciembre de 2001

The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells

artículo científico publicado en 2009

The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms

artículo científico publicado en 2010

Tissue-specific contributions of pneumococcal virulence factors to pathogenesis

artículo científico publicado en 2004

Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties

artículo científico publicado en 2017

Virulence in Mice of Pneumococcal Clonal Types with Known Invasive Disease Potential in Humans

artículo científico publicado en 2005

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

artículo científico publicado en 2015

YopE specific CD8+ T cells provide protection against systemic and mucosal Yersinia pseudotuberculosis infection

artículo científico publicado en 2017

beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae

artículo científico publicado en 2005

β-Arrestin 1 Participates in Platelet-Activating Factor Receptor-Mediated Endocytosis of Streptococcus pneumoniae.

artículo científico publicado en 2006