Lista de obras - José Neptuno Rodríguez-López

A continuous spectrophotometric method for the determination of monophenolase activity of tyrosinase using 3-methyl-2-benzothiazolinone hydrazone

artículo científico publicado en 1994

A review on spectrophotometric methods for measuring the monophenolase and diphenolase activities of tyrosinase.

artículo científico publicado en 2007

Action mechanism of tyrosinase on meta- and para-hydroxylated monophenols

artículo científico publicado en 2000

Analysis and interpretation of the action mechanism of mushroom tyrosinase on monophenols and diphenols generating highly unstable o-quinones.

artículo científico publicado en 2001

Analysis of cholinesterases in human prostate and sperm: implications in cancer and fertility.

artículo científico publicado en 2010

Antifolates as antimycotics? Connection between the folic acid cycle and the ergosterol biosynthesis pathway in Candida albicans

artículo científico publicado en 2006

Binding of natural and synthetic polyphenols to human dihydrofolate reductase.

artículo científico publicado en 2009

Calculating molar absorptivities for quinones: application to the measurement of tyrosinase activity.

artículo científico publicado en 2006

Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer.

artículo científico publicado en 2008

Catalysis and inactivation of tyrosinase in its action on hydroxyhydroquinone.

artículo científico publicado en 2014

Catalytic oxidation of o-aminophenols and aromatic amines by mushroom tyrosinase

artículo científico publicado en 2011

Comparison of a pair of synthetic tea-catechin-derived epimers: synthesis, antifolate activity, and tyrosinase-mediated activation in melanoma.

artículo científico publicado en 2011

Compound I formation in artichoke (Cynara scolymus L.) peroxidase is modulated by the equilibrium between pentacoordinated and 6-aquo hexacoordinated forms of the heme and by calcium ions.

artículo científico publicado en 2003

Determination and applications of the molar absorptivity of phenolic adducts with captopril and mesna.

artículo científico publicado en 2009

Deuterium isotope effect on the oxidation of monophenols and o-diphenols by tyrosinase.

artículo científico publicado en 2004

Deuterium isotope effect on the suicide inactivation of tyrosinase in its action on o‐diphenols ⬇️

artículo científico publicado el 29 de julio de 2013

Directed phenotype switching as an effective antimelanoma strategy.

artículo científico publicado en 2013

Effect of distal cavity mutations on the binding and activation of oxygen by ferrous horseradish peroxidase

scientific article published on 01 January 1997

Effect of tetrahydropteridines on the monophenolase and diphenolase activities of tyrosinase

artículo científico publicado en 2007

Effects of a synthetic antitumoral catechin and its tyrosinase-processed product on the structural properties of phosphatidylcholine membranes

artículo científico publicado en 2014

Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase.

artículo científico publicado en 2010

Ellagic acid: characterization as substrate of polyphenol oxidase.

artículo científico publicado en 2009

Enzymatic method with polyphenol oxidase for the determination of cysteine and N-acetylcysteine.

artículo científico publicado en 2005

Enzyme inactivation analysis for industrial blanching applications: comparison of microwave, conventional, and combination heat treatments on mushroom polyphenoloxidase activity

scientific article published on 01 November 1999

Factors influencing the antifolate activity of synthetic tea-derived catechins.

artículo científico publicado en 2013

Generation of hydrogen peroxide in the melanin biosynthesis pathway.

artículo científico publicado en 2009

Hydrogen peroxide helps in the identification of monophenols as possible substrates of tyrosinase

scientific article published on 07 December 2013

Hydroxylation of p-substituted phenols by tyrosinase: further insight into the mechanism of tyrosinase activity.

artículo científico publicado en 2012

Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol.

artículo científico publicado en 2013

Inhibition of Stenotrophomonas maltophilia dihydrofolate reductase by methotrexate: a single slow-binding process

artículo científico publicado en 2007

Kinetic characterisation of o-aminophenols and aromatic o-diamines as suicide substrates of tyrosinase ⬇️

artículo científico publicado el 10 de febrero de 2012

Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther.

artículo científico publicado en 2002

Kinetic characterization of the enzymatic and chemical oxidation of the catechins in green tea.

artículo científico publicado en 2008

Kinetic characterization of the oxidation of carbidopa and benserazide by tyrosinase and peroxidase.

artículo científico publicado en 2009

Kinetic characterization of the oxidation of chlorogenic acid by polyphenol oxidase and peroxidase. Characteristics of the o-quinone

artículo científico publicado en 2007

Kinetic characterization of the oxidation of esculetin by polyphenol oxidase and peroxidase

artículo científico publicado en 2007

Kinetic study of the effects of calcium ions on cationic artichoke (Cynara scolymus L.) peroxidase: calcium binding, steady-state kinetics and reactions with hydrogen peroxide.

artículo científico publicado en 2004

Kinetic study of the inactivation of ascorbate peroxidase by hydrogen peroxide.

artículo científico publicado en 2000

Laser Photolysis Behavior of Ferrous Horseradish Peroxidase with Carbon Monoxide and Cyanide: Effects of Mutations in the Distal Heme Pocket ⬇️

artículo científico publicado el 14 de noviembre de 1995

Mechanism of Reaction of Hydrogen Peroxide with Horseradish Peroxidase: Identification of Intermediates in the Catalytic Cycle ⬇️

artículo científico publicado el 5 de diciembre de 2001

Mechanism of dihydrofolate reductase downregulation in melanoma by 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.

artículo científico publicado en 2010

Mechanisms of compound I formation in heme peroxidases.

artículo científico publicado en 2002

Melanogenesis Inhibition Due to NADH ⬇️

artículo científico publicado el 7 de septiembre de 2010

Melanogenesis inhibition by tetrahydropterines.

artículo científico publicado en 2009

Melanoma activation of 3-o-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin to a potent irreversible inhibitor of dihydrofolate reductase.

artículo científico publicado en 2009

Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.

artículo científico publicado en 2012

Method for the determination of molar absorptivities of thiol adducts formed from diphenolic substrates of polyphenol oxidase.

artículo científico publicado en 2002

Michaelis constants of mushroom tyrosinase with respect to oxygen in the presence of monophenols and diphenols

artículo científico publicado en 2002

Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.).

artículo científico publicado en 2005

Mutation of Distal Residues of Horseradish Peroxidase: Influence on Substrate Binding and Cavity Properties†

artículo científico publicado en 1997

Opposite effects of peroxidase in the initial stages of tyrosinase-catalysed melanin biosynthesis.

artículo científico publicado en 2005

Oxidation by mushroom tyrosinase of monophenols generating slightly unstable o-quinones.

artículo científico publicado en 2000

Oxymetric and spectrophotometric study of the ascorbate oxidase activity shown by frog epidermis tyrosinase

scientific article published on 01 August 1996

Persister state-directed transitioning and vulnerability in melanoma

artículo científico publicado en 2022

Promoting E2F1-mediated apoptosis in oestrogen receptor-α-negative breast cancer cells

artículo científico publicado en 2014

Purification and Kinetic Characterization of an Anionic Peroxidase from Melon (Cucumis meloL.) Cultivated under Different Salinity Conditions

scientific article published on 01 May 2000

Purification and characterization of a new cationic peroxidase from fresh flowers of Cynara scolymus L

artículo científico publicado en 2003

Purification and kinetic properties of human recombinant dihydrofolate reductase produced in Bombyx mori chrysalides.

artículo científico publicado en 2010

Quantification of the antioxidant capacity of different molecules and their kinetic antioxidant efficiencies

scientific article published on 01 February 2010

Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.

artículo científico publicado en 2012

Reactivity of horseradish peroxidase compound II toward substrates: kinetic evidence for a two-step mechanism

scientific article published on 01 October 2000

Stereospecific inactivation of tyrosinase by L- and D-ascorbic acid.

artículo científico publicado en 2008

Stopped-flow and steady-state study of the diphenolase activity of mushroom tyrosinase

scientific article published on 01 August 2000

Study of umbelliferone hydroxylation to esculetin catalyzed by polyphenol oxidase

artículo científico publicado en 2013

Suicide inactivation of the diphenolase and monophenolase activities of tyrosinase.

artículo científico publicado en 2010

Suicide inactivation of tyrosinase in its action on tetrahydropterines

artículo científico publicado en 2011

Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate.

artículo científico publicado en 2008

Targeting the epigenetic machinery of cancer cells

artículo científico

Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.

artículo científico publicado en 2008

Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans

scientific article published on 03 April 2006

Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinase

artículo científico publicado en 2011

The Distal Cavity Structure of Carbonyl Horseradish Peroxidase As Probed by the Resonance Raman Spectra of His 42 Leu and Arg 38 Leu Mutants†

artículo científico publicado en 1998

The Relationship between the IC<sub>50</sub> Values and the Apparent Inhibition Constant in the Study of Inhibitors of Tyrosinase Diphenolase Activity Helps Confirm the Mechanism of Inhibition

artículo científico publicado en 2022

The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression.

artículo científico publicado en 2008

The antifolate activity of tea catechins.

artículo científico publicado en 2005

The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate.

artículo científico publicado en 2009

The inactivation and catalytic pathways of horseradish peroxidase with m-chloroperoxybenzoic acid. A spectrophotometric and transient kinetic study

artículo científico publicado en 1997

The inactivation of horseradish peroxidase isoenzyme A2 by hydrogen peroxide: an example of partial resistance due to the formation of a stable enzyme intermediate.

artículo científico publicado en 2001

Thermal inactivation of mushroom polyphenoloxidase employing 2450 MHz microwave radiation

scientific article published on 01 August 1999

Tyrosinase-catalyzed hydroxylation of hydroquinone, a depigmenting agent, to hydroxyhydroquinone: A kinetic study

scientific article published on 04 May 2014

Unification for the expression of the monophenolase and diphenolase activities of tyrosinase

artículo científico publicado en 2002

Lista de obras de José Neptuno Rodríguez-López

A continuous spectrophotometric method for the determination of monophenolase activity of tyrosinase using 3-methyl-2-benzothiazolinone hydrazone

A review on spectrophotometric methods for measuring the monophenolase and diphenolase activities of tyrosinase.

Action mechanism of tyrosinase on meta- and para-hydroxylated monophenols

Analysis and interpretation of the action mechanism of mushroom tyrosinase on monophenols and diphenols generating highly unstable o-quinones.

Analysis of cholinesterases in human prostate and sperm: implications in cancer and fertility.

Antifolates as antimycotics? Connection between the folic acid cycle and the ergosterol biosynthesis pathway in Candida albicans

Binding of natural and synthetic polyphenols to human dihydrofolate reductase.

Calculating molar absorptivities for quinones: application to the measurement of tyrosinase activity.

Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer.

Catalysis and inactivation of tyrosinase in its action on hydroxyhydroquinone.

Catalytic oxidation of o-aminophenols and aromatic amines by mushroom tyrosinase

Comparison of a pair of synthetic tea-catechin-derived epimers: synthesis, antifolate activity, and tyrosinase-mediated activation in melanoma.

Compound I formation in artichoke (Cynara scolymus L.) peroxidase is modulated by the equilibrium between pentacoordinated and 6-aquo hexacoordinated forms of the heme and by calcium ions.

Determination and applications of the molar absorptivity of phenolic adducts with captopril and mesna.

Deuterium isotope effect on the oxidation of monophenols and o-diphenols by tyrosinase.

Deuterium isotope effect on the suicide inactivation of tyrosinase in its action on o‐diphenols ⬇️

Directed phenotype switching as an effective antimelanoma strategy.

Effect of distal cavity mutations on the binding and activation of oxygen by ferrous horseradish peroxidase

Effect of tetrahydropteridines on the monophenolase and diphenolase activities of tyrosinase

Effects of a synthetic antitumoral catechin and its tyrosinase-processed product on the structural properties of phosphatidylcholine membranes

Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase.

Ellagic acid: characterization as substrate of polyphenol oxidase.

Enzymatic method with polyphenol oxidase for the determination of cysteine and N-acetylcysteine.

Enzyme inactivation analysis for industrial blanching applications: comparison of microwave, conventional, and combination heat treatments on mushroom polyphenoloxidase activity

Factors influencing the antifolate activity of synthetic tea-derived catechins.

Generation of hydrogen peroxide in the melanin biosynthesis pathway.

Hydrogen peroxide helps in the identification of monophenols as possible substrates of tyrosinase

Hydroxylation of p-substituted phenols by tyrosinase: further insight into the mechanism of tyrosinase activity.

Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol.

Inhibition of Stenotrophomonas maltophilia dihydrofolate reductase by methotrexate: a single slow-binding process

Kinetic characterisation of o-aminophenols and aromatic o-diamines as suicide substrates of tyrosinase ⬇️

Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther.

Kinetic characterization of the enzymatic and chemical oxidation of the catechins in green tea.

Kinetic characterization of the oxidation of carbidopa and benserazide by tyrosinase and peroxidase.

Kinetic characterization of the oxidation of chlorogenic acid by polyphenol oxidase and peroxidase. Characteristics of the o-quinone

Kinetic characterization of the oxidation of esculetin by polyphenol oxidase and peroxidase

Kinetic study of the effects of calcium ions on cationic artichoke (Cynara scolymus L.) peroxidase: calcium binding, steady-state kinetics and reactions with hydrogen peroxide.

Kinetic study of the inactivation of ascorbate peroxidase by hydrogen peroxide.

Laser Photolysis Behavior of Ferrous Horseradish Peroxidase with Carbon Monoxide and Cyanide: Effects of Mutations in the Distal Heme Pocket ⬇️

Mechanism of Reaction of Hydrogen Peroxide with Horseradish Peroxidase: Identification of Intermediates in the Catalytic Cycle ⬇️

Mechanism of dihydrofolate reductase downregulation in melanoma by 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.

Mechanisms of compound I formation in heme peroxidases.

Melanogenesis Inhibition Due to NADH ⬇️

Melanogenesis inhibition by tetrahydropterines.

Melanoma activation of 3-o-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin to a potent irreversible inhibitor of dihydrofolate reductase.

Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.

Method for the determination of molar absorptivities of thiol adducts formed from diphenolic substrates of polyphenol oxidase.

Michaelis constants of mushroom tyrosinase with respect to oxygen in the presence of monophenols and diphenols

Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.).

Mutation of Distal Residues of Horseradish Peroxidase: Influence on Substrate Binding and Cavity Properties†

Opposite effects of peroxidase in the initial stages of tyrosinase-catalysed melanin biosynthesis.

Oxidation by mushroom tyrosinase of monophenols generating slightly unstable o-quinones.

Oxymetric and spectrophotometric study of the ascorbate oxidase activity shown by frog epidermis tyrosinase

Persister state-directed transitioning and vulnerability in melanoma

Promoting E2F1-mediated apoptosis in oestrogen receptor-α-negative breast cancer cells

Purification and Kinetic Characterization of an Anionic Peroxidase from Melon (Cucumis meloL.) Cultivated under Different Salinity Conditions

Purification and characterization of a new cationic peroxidase from fresh flowers of Cynara scolymus L

Purification and kinetic properties of human recombinant dihydrofolate reductase produced in Bombyx mori chrysalides.

Quantification of the antioxidant capacity of different molecules and their kinetic antioxidant efficiencies

Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.

Reactivity of horseradish peroxidase compound II toward substrates: kinetic evidence for a two-step mechanism

Stereospecific inactivation of tyrosinase by L- and D-ascorbic acid.

Stopped-flow and steady-state study of the diphenolase activity of mushroom tyrosinase

Study of umbelliferone hydroxylation to esculetin catalyzed by polyphenol oxidase

Suicide inactivation of the diphenolase and monophenolase activities of tyrosinase.

Suicide inactivation of tyrosinase in its action on tetrahydropterines

Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate.

Targeting the epigenetic machinery of cancer cells

Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.

Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans

Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinase

The Distal Cavity Structure of Carbonyl Horseradish Peroxidase As Probed by the Resonance Raman Spectra of His 42 Leu and Arg 38 Leu Mutants†

The Relationship between the IC<sub>50</sub> Values and the Apparent Inhibition Constant in the Study of Inhibitors of Tyrosinase Diphenolase Activity Helps Confirm the Mechanism of Inhibition

The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression.

The antifolate activity of tea catechins.

The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate.

The inactivation and catalytic pathways of horseradish peroxidase with m-chloroperoxybenzoic acid. A spectrophotometric and transient kinetic study

The inactivation of horseradish peroxidase isoenzyme A2 by hydrogen peroxide: an example of partial resistance due to the formation of a stable enzyme intermediate.

Thermal inactivation of mushroom polyphenoloxidase employing 2450 MHz microwave radiation