Filtros de búsqueda

Lista de obras de

,-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

artículo científico publicado en 2018

2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild type and Cyp27a1-/- Cyp46a1-/- mice with deficiency in the oxysterol production

artículo científico publicado en 2020

7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier.

artículo científico publicado en 2013

A simple and rapid method to measure cholesterol binding to P450s and other proteins

artículo científico publicado en 2005

Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis

artículo científico publicado en 2012

Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

scientific journal article

An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and p450scc (CYP11A1)

artículo científico publicado en 1999

Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1

artículo científico publicado en 2013

Assessment of cholesterol homeostasis in the living human brain

artículo científico publicado en 2022

Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1: UNUSUAL FEATURES AND SPECTRAL RESPONSE

artículo científico publicado en 2013

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain

artículo científico publicado en 2003

CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice

scientific article published on 01 July 2019

CYP46A1-dependent and independent effects of efavirenz treatment

artículo científico publicado en 2020

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

artículo científico publicado en 2003

Chemical modification of adrenocortical cytochrome P-450scc with tetranitromethane

scientific article published on 01 November 1984

Chemical modification of rabbit IgG with N-dansylaziridine. Investigation of the properties of dansylated antibodies

artículo científico publicado en 1991

Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. ⬇️

artículo científico publicado en 2011

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

scientific article published on 01 July 2019

Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis

artículo científico publicado en 2005

Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols

artículo científico publicado en 2015

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis

artículo científico publicado en 2015

Cholesterol in the retina: the best is yet to come.

artículo científico publicado en 2014

Cholesterol-metabolizing cytochromes P450

artículo científico publicado en 2006

Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering

scientific article published on 01 November 2008

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease.

artículo científico publicado en 2017

Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase

scientific article published on 10 January 2009

Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells

artículo científico publicado en 2011

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

artículo científico publicado en 2008

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum

artículo científico publicado en 2017

Cytochromes p450: roles in diseases

artículo científico publicado en 2013

Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies

scientific article published on 01 April 2006

Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo

artículo científico publicado en 2017

Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain.

artículo científico publicado en 2014

Escherichia coli flavodoxin sepharose as an affinity resin for cytochromes P450 and use to identify a putative cytochrome P450c17/3beta-hydroxysteroid dehydrogenase interaction

artículo científico publicado en 1997

Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications

artículo científico publicado en 2004

Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).

artículo científico publicado en 1997

Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.

artículo científico publicado en 2011

Genetically engineered bacterial cells and applications.

artículo científico publicado en 1995

Histone H3 Ser57 and Thr58 phosphorylation in the brain of 5XFAD mice.

artículo científico publicado en 2015

In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine

artículo científico publicado en 2012

In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds

scientific article published on 03 November 2019

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

artículo científico publicado en 2017

Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents

artículo científico publicado en 2012

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1

artículo científico publicado en 2011

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

artículo científico publicado en 2020

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

artículo científico publicado en 2016

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation

artículo científico publicado en 2011

Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters

artículo científico publicado en 2010

Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy

artículo científico publicado en 2015

Mass spectrometry detection of isolevuglandin adduction to specific protein residues

artículo científico publicado en 2015

Mass spectrometry quantification of PICALM and AP180 in human frontal cortex and neural retina

artículo científico publicado en 2013

Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)

artículo científico publicado en 2002

Mechanisms that minimize retinal impact of apolipoprotein E absence

artículo científico publicado en 2018

Membrane binding and substrate access merge in cytochrome P450 7A1, a key enzyme in degradation of cholesterol

artículo científico publicado en 2001

Membrane-protein interactions contribute to efficient 27-hydroxylation of cholesterol by mitochondrial cytochrome P450 27A1.

artículo científico publicado en 2002

Metabolism of 4 beta -hydroxycholesterol in humans.

artículo científico publicado en 2002

Metabolism of a novel side chain modified Delta8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1.

artículo científico publicado en 2008

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid.

artículo científico publicado en 2007

Novel sterols synthesized via the CYP27A1 metabolic pathway.

artículo científico publicado en 2003

On the importance of albumin binding for the flux of 7α-hydroxy-3-oxo-4-cholestenoic acid in the brain

artículo científico publicado en 2016

Optimizing the conditions of a multiple reaction monitoring assay for membrane proteins: quantification of cytochrome P450 11A1 and adrenodoxin reductase in bovine adrenal cortex and retina

artículo científico publicado en 2010

Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments

artículo científico publicado en 2014

Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice

artículo científico publicado en 2013

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1.

artículo científico publicado en 2004

Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1

artículo científico publicado en 2013

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

artículo científico publicado en 2013

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

artículo científico publicado en 2013

Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1

artículo científico publicado en 2001

Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain

artículo científico publicado en 2010

Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain

artículo científico publicado en 2015

Retinal Cholesterol Content is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol

artículo científico publicado en 2018

Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells

artículo científico publicado en 2016

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal

scientific article published on 16 November 2018

Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.

artículo científico publicado en 2014

Sample prefractionation for mass spectrometry quantification of low-abundance membrane proteins

artículo científico publicado en 2012

Selective chemical modification of cytochrome P-450SCC lysine residues. Identification of lysines involved in the interaction with adrenodoxin

artículo científico publicado en 1989

Spatial distribution of the pathways of cholesterol homeostasis in human retina

artículo científico publicado en 2012

Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry

scientific article published on May 2009

Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

artículo científico publicado en 2011

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

artículo científico publicado en 2010

Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain

artículo científico publicado en 2010

Studies of ApoD-/- and ApoD-/-ApoE-/- mice uncover the APOD significance for retinal metabolism, function, and status of chorioretinal blood vessels

artículo científico publicado en 2020

Studies of distant members of the P450 superfamily (P450scc and P450c27) by random chimeragenesis.

artículo científico publicado en 1996

Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1

artículo científico publicado en 2008

The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina

scientific article published on 12 December 2019

The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection

artículo científico publicado en 2009

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

artículo científico publicado en 2009

The tertiary structure of full-length bovine adrenodoxin suggests functional dimers

artículo científico publicado en 2000

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).

artículo científico publicado en 2017

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

artículo científico publicado en 2008

[Chemical modification of cholesterol-hydroxylating cytochrome P450 from bovine adrenal cortex mitochondria by acetylimidazole]

scientific article published on 01 October 1987

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda