Lista de obras - Darragh G McArt - Dominio Público Uruguay

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

artículo científico publicado en 2019

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA

artículo científico publicado en 2019

ACE: A Workbench using Evolutionary Genetic Algorithms for analysing association in TCGA Data

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.

artículo científico publicado en 2013

Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression.

artículo científico publicado en 2014

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

scientific article published on 17 December 2018

Automated tumor analysis for molecular profiling in lung cancer

artículo científico publicado en 2015

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

artículo científico publicado en 2018

Building a 'Repository of Science': The importance of integrating biobanks within molecular pathology programmes.

artículo científico publicado en 2016

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification ⬇️

artículo científico publicado en 2017

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

artículo científico publicado en 2016

Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches

artículo científico publicado en 2019

Comet sensitivity in assessing DNA damage and repair in different cell cycle stages.

artículo científico publicado en 2010

Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility.

artículo científico publicado en 2015

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

artículo científico publicado en 2013

Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

artículo científico publicado en 2015

Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression.

artículo científico publicado en 2018

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

artículo científico publicado en 2018

Digital pathology and image analysis in tissue biomarker research

artículo científico publicado en 2014

Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned.

artículo científico

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

artículo científico publicado en 2015

Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer

artículo científico publicado en 2015

Glucose transporter 1 expression as a marker of prognosis in oesophageal adenocarcinoma.

artículo científico publicado en 2018

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

artículo científico publicado en 2017

Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping

artículo científico publicado en 2011

Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

artículo científico publicado en 2016

Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

article

Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

artículo científico publicado en 2017

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

artículo científico publicado en 2016

Modelling the comet assay.

artículo científico publicado en 2009

Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention

artículo científico publicado en 2015

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.

artículo científico

PICan: An integromics framework for dynamic cancer biomarker discovery

artículo científico publicado en 2015

PP28. THERAPEUTIC COMPOUND DISCOVERY AND VALIDATION OF DRUGS TARGETING A RECURRENT GLIOBLASTOMA (GBM) PHENOTYPE USING LINCS COMPOUNDS VIA QUADRATIC ANALYSES.

artículo científico publicado en 2017

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer.

artículo científico publicado en 2013

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

artículo científico publicado en 2018

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

artículo científico publicado en 2016

QuPath: Open source software for digital pathology image analysis

artículo científico publicado en 2017

QuPath: Open source software for digital pathology image analysis

Quantification of HER2 heterogeneity in breast cancer-implications for identification of sub-dominant clones for personalised treatment

artículo científico publicado en 2016

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer.

artículo científico publicado en 2016

Systematic random sampling of the comet assay.

artículo científico publicado en 2009

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities

artículo científico publicado en 2014

The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer

artículo científico publicado en 2014

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

artículo científico publicado en 2015

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

artículo científico publicado en 2018

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

artículo científico publicado en 2016

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

artículo científico publicado en 2018

Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis

artículo científico publicado en 2013

cudaMap: a GPU accelerated program for gene expression connectivity mapping

artículo científico publicado en 2013

p16 as a prognostic indicator in ovarian/tubal high-grade serous carcinoma

artículo científico publicado en 2015

samExploreR: exploring reproducibility and robustness of RNA-seq results based on SAM files.

artículo científico publicado en 2016

Lista de obras de Darragh G McArt

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA

ACE: A Workbench using Evolutionary Genetic Algorithms for analysing association in TCGA Data

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.

Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression.

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

Automated tumor analysis for molecular profiling in lung cancer

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

Building a 'Repository of Science': The importance of integrating biobanks within molecular pathology programmes.

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification ⬇️

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches

Comet sensitivity in assessing DNA damage and repair in different cell cycle stages.

Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility.

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression.

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

Digital pathology and image analysis in tissue biomarker research

Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned.

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer

Glucose transporter 1 expression as a marker of prognosis in oesophageal adenocarcinoma.

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping

Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

Modelling the comet assay.

Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.

PICan: An integromics framework for dynamic cancer biomarker discovery

PP28. THERAPEUTIC COMPOUND DISCOVERY AND VALIDATION OF DRUGS TARGETING A RECURRENT GLIOBLASTOMA (GBM) PHENOTYPE USING LINCS COMPOUNDS VIA QUADRATIC ANALYSES.

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer.

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

QuPath: Open source software for digital pathology image analysis

QuPath: Open source software for digital pathology image analysis

Quantification of HER2 heterogeneity in breast cancer-implications for identification of sub-dominant clones for personalised treatment

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer.

Systematic random sampling of the comet assay.

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities

The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis

cudaMap: a GPU accelerated program for gene expression connectivity mapping

p16 as a prognostic indicator in ovarian/tubal high-grade serous carcinoma

samExploreR: exploring reproducibility and robustness of RNA-seq results based on SAM files.