Lista de obras - Zhiwei Chen - Dominio Público Uruguay

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

artículo científico publicado en 2022

A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.

artículo científico publicado en 2015

A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination.

artículo científico publicado en 2009

A replicating modified vaccinia tiantan strain expressing an avian-derived influenza H5N1 hemagglutinin induce broadly neutralizing antibodies and cross-clade protective immunity in mice

artículo científico publicado en 2013

AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34 Progenitor Cell Engraftment in Humanized Mice

artículo científico publicado en 2018

Acute infection of Chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B' envelope.

artículo científico publicado en 2010

Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1.

artículo científico publicado en 2002

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

artículo científico publicado en 2022

Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.

artículo científico publicado en 2009

Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

article

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

artículo científico publicado en 2006

Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells.

artículo científico publicado en 2015

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

scientific article published on 17 April 2020

Brain Invasion by CD4(+) T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice

artículo científico publicado en 2016

Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents.

artículo científico publicado en 2008

Chemical resolution of +/- -calanolide A, +/- -cordatolide A and their 11-demethyl analogues

artículo científico publicado en 2007

Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1

artículo científico publicado en 1998

Chronic Δ(9)-Tetrahydrocannabinol Administration Reduces IgE(+)B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin.

artículo científico publicado en 2016

Closing the door to human immunodeficiency virus ⬇️

artículo científico publicado el 12 de marzo de 2013

Community-Based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong

artículo científico publicado en 2015

Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma

artículo científico publicado en 2021

Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody

artículo científico publicado en 2008

Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'.

artículo científico publicado en 2008

Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

artículo científico publicado en 2022

Enhanced infectivity of an R5-tropic simian/human immunodeficiency virus carrying human immunodeficiency virus type 1 subtype C envelope after serial passages in pig-tailed macaques (Macaca nemestrina).

artículo científico publicado en 2000

Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques ⬇️

artículo científico publicado el 2 de febrero de 2011

F18, a novel small-molecule nonnucleoside reverse transcriptase inhibitor, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis.

artículo científico publicado en 2011

Genetic characterization of diverse HIV-1 strains in an immigrant population living in New York City.

artículo científico publicado en 2006

Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mang

artículo científico publicado en 1996

Gut-homing Δ42PD1(+)Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.

artículo científico publicado en 2017

HIV-1 subtype B’ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China ⬇️

artículo científico publicado el 21 de noviembre de 2003

HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN{gamma} signaling.

artículo científico publicado en 2009

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

artículo científico publicado en 2017

Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus.

artículo científico publicado en 2007

High Prevalence of HIV Infection Among Women and Their Children in Henan Province, China

article

High neutralizing antibody titer in intensive care unit patients with COVID-19

artículo científico publicado en 2020

High prevalence of four novel astrovirus genotype species identified from rodents in China

artículo científico publicado en 2017

Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain.

artículo científico publicado en 2005

Human genital epithelial cells capture cell-free human immunodeficiency virus type 1 and transmit the virus to CD4+ Cells: implications for mechanisms of sexual transmission.

artículo científico publicado en 2003

Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.

artículo científico publicado en 1997

Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model

artículo científico publicado en 2016

Imbalances of gut-homing CD4+ T-cell subsets in HIV-1-infected Chinese patients.

artículo científico publicado en 2013

In vitro selection of HIV-1 CRF08_BC variants resistant to reverse transcriptase inhibitors.

artículo científico publicado en 2015

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

artículo científico publicado en 2022

Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa.

artículo científico publicado en 1995

Lignosulfonic acid exhibits broadly anti-HIV-1 activity--potential as a microbicide candidate for the prevention of HIV-1 sexual transmission

artículo científico publicado en 2012

Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus.

artículo científico publicado en 2006

Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china

scientific article published on December 2004

Monkey Models and HIV Vaccine Research

article

Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis.

artículo científico publicado en 2015

Mucosal immunization induces a higher level of lasting neutralizing antibody response in mice by a replication-competent smallpox vaccine: vaccinia Tiantan strain

artículo científico publicado en 2011

Multiple-site DNA vaccination enhances immune responses in mice

artículo científico publicado en 2005

Mycobacterium tuberculosis infection and vaccine development.

artículo científico publicado en 2016

Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.

artículo científico publicado en 1998

Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virus

artículo científico publicado en 1998

Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.

artículo científico publicado en 1998

Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC ⬇️

artículo científico publicado el 17 de febrero de 2012

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

artículo científico publicado en 2020

Potentiating functional antigen-specific CD8⁺ T cell immunity by a novel PD1 isoform-based fusion DNA vaccine.

artículo científico publicado en 2013

Primary SIVsm Isolates Use the CCR5 Coreceptor from Sooty Mangabeys Naturally Infected in West Africa: A Comparison of Coreceptor Usage of Primary SIVsm, HIV-2, and SIVmac ⬇️

artículo científico publicado el 20 de junio de 1998

Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System

artículo científico publicado en 2016

Reactivity of a new Pan-B monoclonal antibody (MA6) against human leukaemias

artículo científico publicado en 1989

Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region.

artículo científico publicado en 2005

Repressive effect of primary virus replication on superinfection correlated with gut-derived central memory CD4(+) T cells in SHIV-infected Chinese rhesus macaques

artículo científico publicado en 2013

SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus.

artículo científico publicado en 2005

Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain.

artículo científico publicado en 2005

Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques.

artículo científico publicado en 2015

Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice.

artículo científico publicado en 2018

The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1.

artículo científico publicado en 2016

The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes.

artículo científico publicado en 2007

The development of an AIDS mucosal vaccine.

artículo científico publicado en 2010

The development of anti-HIV-1 drugs.

artículo científico publicado en 2010

The function of simian chemokine receptors in the replication of SIV ⬇️

artículo científico publicado el 1 de junio de 1998

The route of inoculation determines the tissue tropism of modified vaccinia Tiantan expressing the spike glycoprotein of SARS-CoV in mice.

artículo científico publicado en 2010

Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy.

artículo científico publicado en 2016

Vaccine-elicited CD8+ T cells cure mesothelioma by overcoming tumor-induced immunosuppressive environment.

artículo científico publicado en 2014

Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice

artículo científico publicado en 2019

Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression

artículo científico publicado en 2018

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

scientific article published on 28 August 2020

α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by TGFβ1 during HIV-1 infection.

artículo científico publicado en 2018

Lista de obras de Zhiwei Chen

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.

A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination.

A replicating modified vaccinia tiantan strain expressing an avian-derived influenza H5N1 hemagglutinin induce broadly neutralizing antibodies and cross-clade protective immunity in mice

AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34 Progenitor Cell Engraftment in Humanized Mice

Acute infection of Chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B' envelope.

Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1.

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.

Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells.

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

Brain Invasion by CD4(+) T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice

Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents.

Chemical resolution of +/- -calanolide A, +/- -cordatolide A and their 11-demethyl analogues

Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1

Chronic Δ(9)-Tetrahydrocannabinol Administration Reduces IgE(+)B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin.

Closing the door to human immunodeficiency virus ⬇️

Community-Based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong

Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma

Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody

Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'.

Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

Enhanced infectivity of an R5-tropic simian/human immunodeficiency virus carrying human immunodeficiency virus type 1 subtype C envelope after serial passages in pig-tailed macaques (Macaca nemestrina).

Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques ⬇️

F18, a novel small-molecule nonnucleoside reverse transcriptase inhibitor, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis.

Genetic characterization of diverse HIV-1 strains in an immigrant population living in New York City.

Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mang

Gut-homing Δ42PD1(+)Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.

HIV-1 subtype B’ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China ⬇️

HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN{gamma} signaling.

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus.

High Prevalence of HIV Infection Among Women and Their Children in Henan Province, China

High neutralizing antibody titer in intensive care unit patients with COVID-19

High prevalence of four novel astrovirus genotype species identified from rodents in China

Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain.

Human genital epithelial cells capture cell-free human immunodeficiency virus type 1 and transmit the virus to CD4+ Cells: implications for mechanisms of sexual transmission.

Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.

Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model

Imbalances of gut-homing CD4+ T-cell subsets in HIV-1-infected Chinese patients.

In vitro selection of HIV-1 CRF08_BC variants resistant to reverse transcriptase inhibitors.

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa.

Lignosulfonic acid exhibits broadly anti-HIV-1 activity--potential as a microbicide candidate for the prevention of HIV-1 sexual transmission

Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus.

Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china

Monkey Models and HIV Vaccine Research

Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis.

Mucosal immunization induces a higher level of lasting neutralizing antibody response in mice by a replication-competent smallpox vaccine: vaccinia Tiantan strain

Multiple-site DNA vaccination enhances immune responses in mice

Mycobacterium tuberculosis infection and vaccine development.

Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.

Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virus

Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.

Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC ⬇️

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

Potentiating functional antigen-specific CD8⁺ T cell immunity by a novel PD1 isoform-based fusion DNA vaccine.

Primary SIVsm Isolates Use the CCR5 Coreceptor from Sooty Mangabeys Naturally Infected in West Africa: A Comparison of Coreceptor Usage of Primary SIVsm, HIV-2, and SIVmac ⬇️

Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System

Reactivity of a new Pan-B monoclonal antibody (MA6) against human leukaemias

Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region.

Repressive effect of primary virus replication on superinfection correlated with gut-derived central memory CD4(+) T cells in SHIV-infected Chinese rhesus macaques

SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus.

Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain.

Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques.

Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice.

The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1.

The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes.

The development of an AIDS mucosal vaccine.

The development of anti-HIV-1 drugs.

The function of simian chemokine receptors in the replication of SIV ⬇️

The route of inoculation determines the tissue tropism of modified vaccinia Tiantan expressing the spike glycoprotein of SARS-CoV in mice.

Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy.

Vaccine-elicited CD8+ T cells cure mesothelioma by overcoming tumor-induced immunosuppressive environment.

Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice

Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target