Lista de obras - Satoshi Obika - Dominio Público Uruguay

1,3,9-Triaza-2-oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self-Base Pairs with Three AgI Ions in a Duplex

scientific article published on 10 April 2019

2'-O,4'-C-Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex

scientific article published on 18 October 2018

2′‐O,4′‐C‐Aminomethylene‐Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH ⬇️

artículo científico publicado el 24 de enero de 2011

A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma

artículo científico publicado en 2019

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

scientific article published on 20 May 2019

A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes ⬇️

artículo científico publicado el 27 de septiembre de 2010

Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication

scientific article published on 10 December 2020

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease

artículo científico publicado en 2019

Antisense Drug Discovery and Development ⬇️

artículo científico publicado el 1 de marzo de 2011

Bridged nucleic acid conjugates at 6′-thiol: synthesis, hybridization properties and nuclease resistances ⬇️

artículo científico publicado el 3 de junio de 2011

Chemical modification of triplex-forming oligonucleotide to promote pyrimidine motif triplex formation at physiological pH ⬇️

artículo científico publicado el 9 de enero de 2012

Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth

scientific article published on 15 January 2019

Cleavage of Oligonucleotides Containing a P3’→N5’ Phosphoramidate Linkage Mediated by Single-Stranded Oligonucleotide Templates ⬇️

artículo científico publicado el 20 de diciembre de 2011

Construction of a tri-chromatic reporter cell line for the rapid and simple screening of splice-switching oligonucleotides targeting DMD exon 51 using high content screening.

artículo científico publicado en 2018

Correction: Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1

article

DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences

scientific article published on 11 December 2020

Design, Synthesis, and Properties of Boat-Shaped Glucopyranosyl Nucleic Acid ⬇️

artículo científico publicado el 17 de octubre de 2011

Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1

article

Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides.

artículo científico publicado en 2019

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe])

artículo científico publicado en 2018

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

artículo científico publicado en 2019

High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives

scientific article published on 07 January 2019

Hybridization and Mismatch Discrimination Abilities of 2',4'-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase

scientific article published on 24 January 2019

Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides.

artículo científico publicado en 2017

Increased Expression of Periostin in Vitreous and Fibrovascular Membranes Obtained from Patients with Proliferative Diabetic Retinopathy ⬇️

artículo científico publicado el 29 de julio de 2011

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

artículo científico publicado en 2019

Interrupted 2′-O,4′-C-Aminomethylene Bridged Nucleic Acid Modification Enhances Pyrimidine Motif Triplex-Forming Ability and Nuclease Resistance Under Physiological Condition ⬇️

artículo científico publicado el 1 de enero de 2011

Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties

artículo científico publicado en 2019

Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido([18F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction ⬇️

artículo científico publicado el 19 de noviembre de 2010

Study on Suitability of KOD DNA Polymerase for Enzymatic Production of Artificial Nucleic Acids Using Base/Sugar Modified Nucleoside Triphosphates ⬇️

artículo científico publicado el 12 de noviembre de 2010

Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

scientific article published on 09 April 2020

Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle.

artículo científico publicado en 2016

Synthesis and Properties of Oligonucleotides Having Ethynylphosphonate Linkages

artículo científico publicado en 2020

Synthesis and Properties of a Bridged Nucleic Acid with a Perhydro-1,2-oxazin-3-one Ring ⬇️

artículo científico publicado el 15 de noviembre de 2011

Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure ⬇️

artículo científico publicado el 22 de mayo de 2012

Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides

artículo científico publicado en 2020

Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base.

artículo científico publicado en 2017

Synthesis of 2'-C,4'-C-Methyleneoxy-Bridged Thymidine Derivatives and Properties of Modified Oligonucleotides

artículo científico publicado en 2019

Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base

artículo científico publicado en 2019

Synthetic Method for 2'-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction.

artículo científico publicado en 2018

Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA

artículo científico publicado en 2020

Thioamide-Bridged Nucleic Acid (thioAmNA) Containing Thymine or 2-Thiothymine: Duplex-Forming Ability, Base Discrimination, and Enzymatic Stability

scientific article published on 04 March 2019

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.

artículo científico publicado en 2016

Lista de obras de Satoshi Obika

1,3,9-Triaza-2-oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self-Base Pairs with Three AgI Ions in a Duplex

2'-O,4'-C-Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex

2′‐O,4′‐C‐Aminomethylene‐Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH ⬇️

A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes ⬇️

Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease

Antisense Drug Discovery and Development ⬇️

Bridged nucleic acid conjugates at 6′-thiol: synthesis, hybridization properties and nuclease resistances ⬇️

Chemical modification of triplex-forming oligonucleotide to promote pyrimidine motif triplex formation at physiological pH ⬇️

Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth

Cleavage of Oligonucleotides Containing a P3’→N5’ Phosphoramidate Linkage Mediated by Single-Stranded Oligonucleotide Templates ⬇️

Construction of a tri-chromatic reporter cell line for the rapid and simple screening of splice-switching oligonucleotides targeting DMD exon 51 using high content screening.

Correction: Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1

DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences

Design, Synthesis, and Properties of Boat-Shaped Glucopyranosyl Nucleic Acid ⬇️

Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1

Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides.

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe])

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives

Hybridization and Mismatch Discrimination Abilities of 2',4'-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase

Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides.

Increased Expression of Periostin in Vitreous and Fibrovascular Membranes Obtained from Patients with Proliferative Diabetic Retinopathy ⬇️

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

Interrupted 2′-O,4′-C-Aminomethylene Bridged Nucleic Acid Modification Enhances Pyrimidine Motif Triplex-Forming Ability and Nuclease Resistance Under Physiological Condition ⬇️

Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties

Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido([18F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction ⬇️

Study on Suitability of KOD DNA Polymerase for Enzymatic Production of Artificial Nucleic Acids Using Base/Sugar Modified Nucleoside Triphosphates ⬇️

Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle.

Synthesis and Properties of Oligonucleotides Having Ethynylphosphonate Linkages

Synthesis and Properties of a Bridged Nucleic Acid with a Perhydro-1,2-oxazin-3-one Ring ⬇️

Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure ⬇️

Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides

Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base.

Synthesis of 2'-C,4'-C-Methyleneoxy-Bridged Thymidine Derivatives and Properties of Modified Oligonucleotides

Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base

Synthetic Method for 2'-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction.

Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA

Thioamide-Bridged Nucleic Acid (thioAmNA) Containing Thymine or 2-Thiothymine: Duplex-Forming Ability, Base Discrimination, and Enzymatic Stability

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.