Lista de obras - Don A McClain - Dominio Público Uruguay

A genetic mechanism for Tibetan high-altitude adaptation

artículo científico publicado en 2014

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues

scientific article published on 01 June 1997

Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.

artículo científico publicado en 2003

Adipocyte iron regulates adiponectin and insulin sensitivity

artículo científico publicado en 2012

Adipocyte iron regulates leptin and food intake

artículo científico publicado en 2015

Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

artículo científico publicado en 2002

Analysis of hepatic glycogen-associated proteins.

artículo científico publicado en 2010

Analysis of the stimulation-inhibition paradox exhibited by lymphocytes exposed to concanavalin A ⬇️

artículo científico publicado el 1 de diciembre de 1976

Anti-obesity and pro-diabetic effects of hemochromatosis

artículo científico publicado en 2014

Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.

artículo científico publicado en 2004

Chimeric receptors expressing juxtamembrane sequences of the insulin receptor undergo rapid endocytosis in the absence of receptor tyrosine kinase activity.

artículo científico publicado en 1995

Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes.

artículo científico publicado en 2007

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

artículo científico publicado en 2009

Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism

artículo científico publicado en 2012

Diabetes and hemochromatosis

artículo científico

Dietary iron controls circadian hepatic glucose metabolism through heme synthesis

artículo científico publicado en 2014

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

artículo científico publicado en 1991

Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison.

artículo científico publicado en 2014

Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia

artículo científico publicado en 2000

Further insights into leptin action

artículo científico publicado en 1998

Genetic determinants of Tibetan high-altitude adaptation.

artículo científico publicado en 2011

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease

artículo científico publicado en 2015

Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway

artículo científico publicado en 1993

Hexosamines as mediators of nutrient sensing and regulation in diabetes.

artículo científico publicado en 2002

Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells.

artículo científico publicado en 2005

Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13

artículo científico publicado en 1995

Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis.

artículo científico publicado en 2007

Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway

artículo científico publicado en 2010

Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study.

artículo científico publicado en 2009

Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo

scientific article published on 01 April 1998

Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.

artículo científico publicado en 2003

Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika (Ochotona curzoniae)

artículo científico publicado en 2015

Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.

artículo científico publicado en 2014

Introduction to a mini-forum on "glyconutrients"

artículo científico publicado en 2008

Iron and diabetes risk

artículo científico publicado en 2013

Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB

artículo científico publicado en 2019

Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. ⬇️

artículo científico publicado en 2010

Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.

artículo científico publicado en 2008

Local release of masitinib alters in vivo implantable continuous glucose sensor performance.

artículo científico publicado en 2015

Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion

artículo científico publicado en 2013

Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes.

artículo científico publicado en 2015

Metabolic aspects of high-altitude adaptation in Tibetans.

artículo científico

Metabolic insight into mechanisms of high-altitude adaptation in Tibetans

artículo científico publicado en 2012

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

artículo científico publicado en 2012

Muscle damage and muscle remodeling: no pain, no gain?

artículo científico publicado en 2011

MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.

artículo científico publicado en 2015

Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.

artículo científico publicado en 2009

Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis

artículo científico publicado en 2010

Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.

artículo científico publicado en 2004

PAS kinase is required for normal cellular energy balance

scientific journal article

Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic β-cell function and vascularization.

artículo científico publicado en 2011

Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells

artículo científico publicado en 2008

Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes

artículo científico publicado en 2012

Regulation of Akt signaling by O-GlcNAc in euglycemia.

artículo científico publicado en 2008

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

artículo científico publicado en 2013

Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans

artículo científico publicado en 2014

Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver

artículo científico publicado en 2016

The 3T3-L1 adipocyte glycogen proteome.

artículo científico publicado en 2013

The Utah Center for Clinical and Translational Science: transformation through collaboration

artículo científico publicado en 2012

The effects of sodium metaperiodate on T and B lymphocytes

artículo científico publicado en 1975

The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts

artículo científico publicado en 1990

The role of mPer2 clock gene in glucocorticoid and feeding rhythms.

artículo científico publicado en 2009

Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors ⬇️

artículo científico publicado el 1 de junio de 1992

UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues

artículo científico publicado en 1997

Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux.

scientific article published on 10 December 2008

Lista de obras de Don A McClain

A genetic mechanism for Tibetan high-altitude adaptation

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues

Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.

Adipocyte iron regulates adiponectin and insulin sensitivity

Adipocyte iron regulates leptin and food intake

Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

Analysis of hepatic glycogen-associated proteins.

Analysis of the stimulation-inhibition paradox exhibited by lymphocytes exposed to concanavalin A ⬇️

Anti-obesity and pro-diabetic effects of hemochromatosis

Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.

Chimeric receptors expressing juxtamembrane sequences of the insulin receptor undergo rapid endocytosis in the absence of receptor tyrosine kinase activity.

Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes.

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism

Diabetes and hemochromatosis

Dietary iron controls circadian hepatic glucose metabolism through heme synthesis

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison.

Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia

Further insights into leptin action

Genetic determinants of Tibetan high-altitude adaptation.

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease

Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway

Hexosamines as mediators of nutrient sensing and regulation in diabetes.

Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells.

Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13

Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis.

Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway

Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study.

Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo

Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.

Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika (Ochotona curzoniae)

Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.

Introduction to a mini-forum on "glyconutrients"

Iron and diabetes risk

Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB

Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. ⬇️

Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.

Local release of masitinib alters in vivo implantable continuous glucose sensor performance.

Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion

Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes.

Metabolic aspects of high-altitude adaptation in Tibetans.

Metabolic insight into mechanisms of high-altitude adaptation in Tibetans

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

Muscle damage and muscle remodeling: no pain, no gain?

MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.

Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.

Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis

Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.

PAS kinase is required for normal cellular energy balance

Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic β-cell function and vascularization.

Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells

Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes

Regulation of Akt signaling by O-GlcNAc in euglycemia.

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans

Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver

The 3T3-L1 adipocyte glycogen proteome.

The Utah Center for Clinical and Translational Science: transformation through collaboration

The effects of sodium metaperiodate on T and B lymphocytes

The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts

The role of mPer2 clock gene in glucocorticoid and feeding rhythms.

Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors ⬇️

UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues

Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux.