Lista de obras - Luis Miguel Ruiz-Pérez - Dominio Público Uruguay

1,2-Diphenoxiethane salts as potent antiplasmodial agents.

artículo científico publicado en 2018

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments

scientific article published on 01 July 1996

A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.

artículo científico publicado en 2004

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

scientific article published on 01 July 2006

Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.

artículo científico publicado en 2011

Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms.

artículo científico publicado en 2018

Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli

artículo científico publicado en 1999

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

artículo científico publicado en 2003

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

artículo científico publicado en 2016

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei ⬇️

artículo científico publicado el 14 de octubre de 2013

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei

artículo científico publicado en 2016

Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

artículo científico publicado en 2000

Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

artículo científico publicado en 2002

Co-existence of circular and multiple linear amplicons in methotrexate-resistantLeishmania ⬇️

artículo científico publicado el 11 de agosto de 1995

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major

artículo científico publicado en 2007

Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.

artículo científico publicado en 2008

Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

artículo científico publicado en 2008

Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.

artículo científico publicado en 1997

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.

artículo científico publicado en 2008

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.

artículo científico publicado en 2006

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

artículo científico publicado en 2016

Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase

artículo científico publicado en 2007

Effect of interferon on the infectivity of Trypanosoma cruzi in cultured heLa cells

artículo científico publicado en 1985

Effect of poly-l-lysine and neuraminidase on the infectivity of Trypanosoma cruzi in cultured HeLa cells

artículo científico publicado en 1985

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

artículo científico publicado en 2012

Evaluation of azasterols as anti-parasitics.

artículo científico publicado en 2006

Evidence for a wide occurrence of proton-translocating pyrophosphatase genes in parasitic and free-living protozoa

scientific article published on 01 June 2002

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

artículo científico publicado en 2010

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

artículo científico publicado en 2015

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

artículo científico publicado en 2006

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

artículo científico publicado en 2014

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.

artículo científico publicado en 2009

In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives

artículo científico publicado en 2014

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

artículo científico publicado en 2012

Inhibition of lysosomal fusion by Trypanosoma cruzi in peritoneal macrophages

artículo científico publicado en 1986

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.

artículo científico publicado en 2017

Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

artículo científico publicado en 2008

Isolation and purification of amastigotes of Trypanosoma cruzi from cultured Vero cells

artículo científico publicado en 1985

Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.

artículo científico publicado en 2011

Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.

artículo científico publicado en 2008

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

artículo científico publicado en 2002

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

artículo científico publicado en 2009

MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii

artículo científico publicado en 2014

MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353

artículo científico publicado en 2018

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

artículo científico publicado en 2014

New Antiparasitic Agents

artículo científico publicado en 1988

New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

artículo científico publicado en 2006

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

artículo científico publicado en 2004

Novel inhibitors of Leishmanial dihydrofolate reductase.

artículo científico publicado en 2001

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

artículo científico publicado en 2001

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

artículo científico publicado en 2005

Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives

artículo científico publicado en 2007

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

artículo científico publicado en 2010

Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics.

artículo científico publicado en 2005

Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.

artículo científico publicado en 2000

Purification of a glycoprotein excreted by Trypanosomacruzi to increase the permeability of the host-cell membrane

scientific article published on 01 January 1990

Purification of metacyclic forms of Trypanosoma cruzi by Percoll discontinuous gradient centrifugation

artículo científico publicado en 1984

Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.

artículo científico publicado en 2012

Resistance to reinfection of HeLa cells parasitized by Trypanosoma cruzi

artículo científico publicado en 1984

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

artículo científico publicado en 2010

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

artículo científico publicado en 2012

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

scientific journal article

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

artículo científico publicado en 1999

Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents ⬇️

artículo científico publicado el 29 de octubre de 2011

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

artículo científico publicado en 2012

dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

artículo científico publicado en 2005

Lista de obras de Luis Miguel Ruiz-Pérez

1,2-Diphenoxiethane salts as potent antiplasmodial agents.

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments

A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.

Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms.

Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei ⬇️

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei

Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

Co-existence of circular and multiple linear amplicons in methotrexate-resistantLeishmania ⬇️

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major

Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.

Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase

Effect of interferon on the infectivity of Trypanosoma cruzi in cultured heLa cells

Effect of poly-l-lysine and neuraminidase on the infectivity of Trypanosoma cruzi in cultured HeLa cells

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

Evaluation of azasterols as anti-parasitics.

Evidence for a wide occurrence of proton-translocating pyrophosphatase genes in parasitic and free-living protozoa

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.

In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

Inhibition of lysosomal fusion by Trypanosoma cruzi in peritoneal macrophages

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.

Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

Isolation and purification of amastigotes of Trypanosoma cruzi from cultured Vero cells

Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.

Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii

MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

New Antiparasitic Agents

New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

Novel inhibitors of Leishmanial dihydrofolate reductase.

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics.

Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.

Purification of a glycoprotein excreted by Trypanosomacruzi to increase the permeability of the host-cell membrane

Purification of metacyclic forms of Trypanosoma cruzi by Percoll discontinuous gradient centrifugation

Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.

Resistance to reinfection of HeLa cells parasitized by Trypanosoma cruzi

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents ⬇️

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.