Lista de obras -

A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ

artículo científico publicado en 2018

A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. ⬇️

artículo científico publicado en 2017

A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

artículo científico publicado en 2017

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

artículo científico publicado en 2017

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs

scientific article published on 03 February 2020

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] cluster

artículo científico publicado en 2018

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

artículo científico publicado en 2016

Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module

artículo científico publicado en 2018

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula

artículo científico publicado en 2004

Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways

artículo científico publicado en 2014

Characterization of the initial enzymatic steps of barbamide biosynthesis

artículo científico publicado en 2006

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

artículo científico publicado en 2017

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria ⬇️

artículo científico publicado en 2015

Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics

artículo científico publicado en 2020

Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes

artículo científico publicado en 2020

Conformational switch triggered by -ketoglutarate in a halogenase of curacin A biosynthesis

artículo científico publicado en 2010

Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases

artículo científico publicado en 2020

Correction to “Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Terrestrial Fungus Aspergillus amoenus: Biogenetic Implications” ⬇️

artículo científico publicado en 2017

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

artículo científico publicado en 2010

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching

artículo científico publicado en 2007

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

artículo científico publicado en 2013

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

artículo científico publicado en 2016

Engineered Production of Hapalindole Alkaloids in the Cyanobacterium Synechococcus sp. UTEX 2973

scientific article published on 19 July 2019

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units

scientific article published on 24 January 2019

Enzyme evolution in fungal indole alkaloid biosynthesis

artículo científico publicado en 2020

Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows ⬇️

artículo científico publicado en 2015

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

scientific article published on 05 September 2019

Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

artículo científico publicado en 2017

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase

artículo científico publicado en 2019

GNAT-like strategy for polyketide chain initiation

artículo científico publicado en 2007

Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product

artículo científico publicado en 2012

Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.

artículo científico publicado en 2017

Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair

artículo científico publicado en 2006

Metamorphic enzyme assembly in polyketide diversification

artículo científico publicado en 2009

Minimum Information about a Biosynthetic Gene cluster.

artículo científico publicado en 2015

Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway

scientific article published on 16 January 2020

Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway

artículo científico publicado en 2020

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria

artículo científico publicado en 2009

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

artículo científico publicado en 2019

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis

artículo científico publicado en 2009

Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

artículo científico publicado en 2017

Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis

scientific article published on 27 November 2019

Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.

artículo científico publicado en 2017

Stereoselective Synthesis of Baulamycin A

artículo científico publicado en 2020

Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase

artículo científico publicado en 2015

Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways

artículo científico publicado en 2012

Structural Basis of Polyketide Synthase O-Methylation

artículo científico publicado en 2018

Structure and activity of DmmA, a marine haloalkane dehalogenase ⬇️

artículo científico publicado el 4 de enero de 2012

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect

artículo científico publicado en 2011

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

artículo científico publicado en 2011

The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide

artículo científico publicado en 2015

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

artículo científico publicado en 2002

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

artículo científico publicado en 2010

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity

artículo científico publicado en 2016

Lista de obras de

A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ

A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. ⬇️

A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] cluster

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula

Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways

Characterization of the initial enzymatic steps of barbamide biosynthesis

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria ⬇️

Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics

Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes

Conformational switch triggered by -ketoglutarate in a halogenase of curacin A biosynthesis

Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases

Correction to “Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Terrestrial Fungus Aspergillus amoenus: Biogenetic Implications” ⬇️

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

Engineered Production of Hapalindole Alkaloids in the Cyanobacterium Synechococcus sp. UTEX 2973

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units

Enzyme evolution in fungal indole alkaloid biosynthesis

Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows ⬇️

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase

GNAT-like strategy for polyketide chain initiation

Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product

Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.

Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair

Metamorphic enzyme assembly in polyketide diversification

Minimum Information about a Biosynthetic Gene cluster.

Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway

Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis

Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis

Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.

Stereoselective Synthesis of Baulamycin A

Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase

Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways

Structural Basis of Polyketide Synthase O-Methylation

Structure and activity of DmmA, a marine haloalkane dehalogenase ⬇️

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity