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5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.

artículo científico publicado en 2011

A Chinese family carrying novel mutations in SEC23B and HFE2, the genes responsible for congenital dyserythropoietic anaemia II (CDA II) and primary iron overload, respectively

article

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.

artículo científico publicado en 2018

A comparison of self-reported and record-linked blood donation history in an Australian cohort

artículo científico publicado en 2011

A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis.

artículo científico publicado en 2013

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy.

artículo científico publicado en 2013

A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9

artículo científico publicado en 1998

A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development

artículo científico publicado en 2008

A novel mutation in ferroportin implicated in iron overload

scientific article published on 28 February 2007

A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption.

artículo científico publicado en 2003

Accurate assessment of systemic iron status in cystic fibrosis will avoid the hazards of inappropriate iron supplementation.

artículo científico publicado en 2012

Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice.

artículo científico publicado en 2009

Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis

artículo científico publicado en 2011

An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy

artículo científico publicado en 2019

An injectable hexapeptide hydrogel for localized chemotherapy prevents breast cancer recurrence.

artículo científico publicado en 2018

Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population

article

Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition

artículo científico publicado en 2020

Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases.

artículo científico publicado en 2016

Cell-specific location of Hfe: It is the 'cyte that matters

artículo científico publicado en 2008

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux

artículo científico publicado en 2018

Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat

scientific journal article

Characterization of Putative Erythroid Regulators of Hepcidin in Mouse Models of Anemia.

artículo científico publicado en 2017

Circulating gastrin is increased in hemochromatosis

artículo científico publicado en 2006

Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis

artículo científico publicado en 2018

Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes.

artículo científico publicado en 2018

Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins

scientific article published on 01 October 2001

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

artículo científico publicado en 2009

Control of iron absorption.

artículo científico publicado en 1996

Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging

artículo científico publicado en 2011

Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.

artículo científico publicado en 2017

Correction to Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth

artículo científico publicado en 2020

Correlation of serum hepcidin levels with disease progression in hepatitis B virus-related disease assessed by nanopore film based assay

artículo científico publicado en 2016

Current understanding of iron homeostasis.

artículo científico publicado en 2017

Cystic fibrosis: ironing out the problem of infection?

artículo científico publicado en 2008

DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian alagille syndrome patients

artículo científico publicado en 2002

Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency

artículo científico publicado en 2006

Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.

artículo científico publicado en 2004

Desialylated transferrin as a serological marker of chronic excessive alcohol ingestion

scientific article published on 01 June 1987

Dietary iron absorption during early postnatal life

scientific article published on 23 February 2019

Dietary iron depletion at weaning imprints low microbiome diversity and this is not recovered with oral Nano Fe(III).

artículo científico publicado en 2014

Direct evidence for catalase and peroxidase activities of ferritin–platinum nanoparticles

article

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

artículo científico publicado en 2003

Duodenal expression of iron transport molecules in untreated haemochromatosis subjects.

artículo científico publicado en 2003

Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy

artículo científico publicado en 2012

Elevated iron absorption in the neonatal rat reflects high expression of iron transport genes in the distal alimentary tract.

artículo científico publicado en 2007

Elevated metal concentrations in the CF airway correlate with cellular injury and disease severity.

artículo científico publicado en 2013

Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors

artículo científico publicado en 2019

Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 ( BRCA2) Mutation

artículo científico publicado en 2018

Essential but toxic: controlling the flux of iron in the body.

artículo científico publicado en 2012

Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury

artículo científico publicado en 2013

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.

artículo científico publicado en 2015

Ferric iron reduction and iron assimilation in Saccharomyces cerevisiae.

artículo científico publicado en 1992

Ferroportin Is Essential for Iron Absorption During Suckling, But Is Hyporesponsive to the Regulatory Hormone Hepcidin

artículo científico publicado en 2016

Ferroportin mediates the intestinal absorption of iron from a nanoparticulate ferritin core mimetic in mice.

artículo científico publicado en 2014

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

article

Food deprivation increases hepatic hepcidin expression and can overcome the effect of Hfe deletion in male mice

artículo científico publicado en 2018

Functional Analysis of GLRX5 Mutants Reveals Distinct Functionalities of GLRX5 Protein.

artículo científico publicado en 2015

GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes.

artículo científico publicado en 2016

Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency

artículo científico publicado en 2011

Gastrins, iron homeostasis and colorectal cancer

artículo científico publicado el 12 de febrero de 2011

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer

artículo científico publicado en 2010

HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity

artículo científico publicado en 2009

HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis

artículo científico publicado en 2010

HFE gene and hemochromatosis.

artículo científico publicado en 2004

HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women

artículo científico publicado en 2017

Haemochromatosis and control of intestinal iron absorption

scientific article published on 01 June 1999

Hemojuvelin (HJV)-associated hemochromatosis: analysis of HJV and HFE mutations and iron overload in three families

scientific article published on 01 February 2005

Hepatic iron metabolism.

artículo científico publicado en 2005

Hepcidin compared with prohepcidin: an absorbing story

scientific article published on 16 December 2008

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

artículo científico publicado en 2002

Hepcidin independent iron recycling in a mouse model of β-thalassaemia intermedia.

artículo científico publicado en 2016

Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease.

artículo científico publicado en 2006

Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response.

artículo científico publicado en 2009

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.

artículo científico publicado en 2016

Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.

artículo científico publicado en 2015

Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice

artículo científico publicado en 2004

Heterozygous missense mutations in the GLRX5 gene cause sideroblastic anemia in a Chinese patient

article

High Dietary Iron Disrupts Iron Homeostasis and Induces Amyloid-β and Phospho-τ Expression in the Hippocampus of Adult Wild-Type and APP/PS1 Transgenic Mice

artículo científico publicado en 2019

How much iron is too much?

artículo científico publicado en 2008

Identification of H- and L-ferritin subunit binding sites on human T and B lymphoid cells

scientific article published on 01 October 1989

Identification of two novel PBGD mutations in acute intermittent porphyria patients accompanying anemia in mainland China

article

Impaired iron transport activity of ferroportin 1 in hereditary iron overload

artículo científico publicado en 2005

Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis

artículo científico publicado en 2004

Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE

artículo científico publicado en 2004

Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis.

artículo científico publicado en 2017

Interacting signals in the control of hepcidin expression.

artículo científico publicado en 2009

Interrelationships between circulating gastrin and iron status in mice and humans

artículo científico publicado en 2008

Intestinal Iron Transport and its Regulation

artículo científico publicado en 2001

Intestinal hephaestin potentiates iron absorption in weanling, adult, and pregnant mice under physiological conditions

artículo científico publicado en 2017

Intestinal iron absorption during suckling in mammals

artículo científico publicado el 26 de febrero de 2011

Intestinal iron absorption.

artículo científico publicado en 2012

Intestinal transferrin receptors and iron absorption in the neonatal rat

scientific article published on 01 February 1991

Iron Wars - The Host Strikes Back

artículo científico publicado en 2018

Iron absorption and metabolism.

artículo científico publicado en 2009

Iron homeostasis: transport, metabolism, and regulation.

artículo científico publicado en 2016

Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression.

artículo científico publicado en 2005

Iron metabolism meets signal transduction

artículo científico publicado en 2006

Iron supplementation has minor effects on gut microbiota composition in overweight and obese women in early pregnancy

artículo científico publicado en 2018

Iron-overload-related disease in HFE hereditary hemochromatosis

artículo científico publicado en 2008

Is there a better way to set population iron recommendations?

artículo científico publicado en 2017

Large scale expression and purification of secreted mouse hephaestin

artículo científico publicado en 2017

Liver-gut axis in the regulation of iron homeostasis.

artículo científico publicado en 2007

Mammalian iron transport.

scientific article published on 31 May 2009

Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse.

artículo científico publicado en 1998

Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism

artículo científico publicado en 2005

Mechanisms of iron loading and toxicity.

artículo científico publicado en 2007

Mechanistic and regulatory aspects of intestinal iron absorption

artículo científico publicado en 2014

Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis

artículo científico publicado en 2019

Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse

artículo científico publicado en 2004

Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase

scientific article published on 24 January 2020

Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism

artículo científico publicado en 2002

Molecular basis of iron-loading disorders.

artículo científico publicado en 2010

Multi-Copper Ferroxidase-Deficient Mice Have Increased Brain Iron Concentrations and Learning and Memory Deficits.

artículo científico publicado en 2018

Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models

Mutations in the HFE gene can be associated with increased lung disease severity in cystic fibrosis

article

Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans

artículo científico publicado en 2014

Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids.

artículo científico publicado en 2014

Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain

artículo científico publicado en 2017

Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study

artículo científico publicado en 2015

Non-transferrin-bound iron and cellular toxicity

artículo científico publicado en 1999

Polymeric Nanoparticles Enhance the Ability of Deferoxamine To Deplete Hepatic and Systemic Iron

artículo científico publicado en 2018

Postnatal growth restriction and gene expression changes in a mouse model of fetal alcohol syndrome.

artículo científico publicado en 2010

Pumping iron: a potential target for novel therapeutics against schistosomes

artículo científico publicado en 2007

Pyocyanin-induced toxicity in A549 respiratory cells is causally linked to oxidative stress

artículo científico publicado en 2011

Pyrosequencing reveals transient cystic fibrosis lung microbiome changes with intravenous antibiotics.

artículo científico publicado en 2014

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

artículo científico publicado en 2016

Reduced expression of ferroportin-1 mediates hyporesponsiveness of suckling rats to stimuli that reduce iron absorption.

artículo científico publicado en 2011

Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials

artículo científico publicado en 2015

Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial

artículo científico publicado en 2017

Regulation of systemic iron homeostasis: how the body responds to changes in iron demand

artículo científico publicado en 2007

Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption

scientific article published in 2002

Reply

artículo científico publicado en 2017

Reply

artículo científico publicado en 2015

Reply

scientific article published on 15 March 2016

Reply: To PMID 25605615.

artículo científico publicado en 2015

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

artículo científico publicado en 2018

Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats.

artículo científico publicado en 2009

SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis

artículo científico publicado en 2008

Screening for hemochromatosis in asymptomatic subjects with or without a family history

artículo científico publicado en 2006

Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy.

artículo científico publicado en 2018

Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis.

artículo científico publicado en 2009

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin

scientific article published on 23 June 2018

Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron)

artículo científico publicado en 2015

Simple radioimmunoassay for transferrin using insolubilized antitransferrin antibodies: its application to cultured cells

artículo científico publicado en 1986

Small-molecule dissection of BMP signaling

artículo científico publicado en 2008

Specific tissue factor delivery using a tumor-homing peptide for inducing tumor infarction

scientific article published on 15 September 2018

Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression.

artículo científico publicado en 2012

Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis

artículo científico publicado en 2017

Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells.

artículo científico publicado en 2012

Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency

artículo científico publicado en 2003

Systemic regulation of intestinal iron absorption.

artículo científico publicado en 2005

Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice

artículo científico publicado en 2018

Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth

scientific article published on 28 January 2019

Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis.

artículo científico publicado en 2012

The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption.

artículo científico publicado en 2002

The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis

artículo científico publicado en 2006

The fission yeast ferric reductase gene frp1+ is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase.

artículo científico publicado en 1993

The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice

artículo científico publicado en 2014

The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis

artículo científico publicado en 2008

The orchestration of body iron intake: how and where do enterocytes receive their cues?

artículo científico publicado en 2003

The regulation of iron transport.

artículo científico

The role of duodenal cytochrome b in intestinal iron absorption remains unclear.

artículo científico publicado en 2005

Things that go BMP in the liver: bone morphogenetic protein 6 and the control of body iron homeostasis

artículo científico publicado en 2009

Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis.

artículo científico publicado en 2004

Transferrin receptor distribution and regulation in the rat small intestine. Effect of iron stores and erythropoiesis

artículo científico publicado en 1990

Transferrin receptors in hemochromatosis

artículo científico publicado en 1987

Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with β-thalassemia major: a longitudinal study

artículo científico publicado en 2013

pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth

artículo científico publicado en 2015