Lista de obras - Evripidis Gavathiotis - Dominio Público Uruguay

A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival ⬇️

artículo científico publicado el 21 de septiembre de 2012

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy

artículo científico publicado en 2020

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

artículo científico publicado en 2012

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

artículo científico publicado en 2021

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

artículo científico publicado en 2016

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

artículo científico publicado en 2016

An interconnected hierarchical model of cell death regulation by the BCL-2 family

artículo científico publicado en 2015

BAX activation is initiated at a novel interaction site

artículo científico publicado en 2008

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

artículo científico publicado en 2011

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

artículo científico publicado en 2010

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells

artículo científico publicado en 2019

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

artículo científico publicado en 2021

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

artículo científico publicado en 2021

Chemical genetics: Unraveling cell death mysteries.

artículo científico publicado en 2016

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

artículo científico publicado en 2013

Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study ⬇️

artículo científico publicado el 19 de diciembre de 2001

Correcting mitochondrial fusion by manipulating mitofusin conformations

artículo científico publicado en 2016

Current Insights of BRAF Inhibitors in Cancer.

artículo científico publicado en 2018

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

artículo científico publicado en 2017

Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.

artículo científico publicado en 2014

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

artículo científico publicado en 2017

Direct and selective small-molecule activation of proapoptotic BAX

artículo científico publicado en 2012

Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.

artículo científico publicado en 2014

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

artículo científico publicado en 2003

Editorial overview: Chemical genetics and epigenetics.

artículo científico publicado en 2017

Eltrombopag directly inhibits BAX and prevents cell death

artículo científico publicado en 2021

Erratum: Corrigendum: Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

scholarly article published in Nature Chemical Biology

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

artículo científico publicado en 2010

ICBS 2017 in Shanghai-Illuminating Life with Chemical Innovation.

artículo científico publicado en 2018

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.

artículo científico publicado en 2016

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

artículo científico publicado en 2015

Inhibitors of BRAF dimers using an allosteric site

artículo científico publicado en 2020

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

artículo científico publicado en 2018

Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

artículo científico publicado en 2014

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

artículo científico publicado en 2018

Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3

artículo científico publicado en 2013

New perspectives for targeting RAF kinase in human cancer.

artículo científico publicado en 2017

Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1

scientific article published on 11 January 2019

Pharmacological inhibition of the transcription factor PU.1 in leukemia

artículo científico publicado en 2017

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

artículo científico publicado en 2010

Progress in targeting the BCL-2 family of proteins.

artículo científico publicado en 2017

Pulling the BAX trigger for tumor cell death.

artículo científico publicado en 2018

Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4

scholarly article by Evripidis Gavathiotis et al published 17 December 2001 in Angewandte Chemie International Edition

Self-regulation of BAX-induced cell death.

artículo científico publicado en 2016

Small-molecule allosteric inhibitors of BAX

scientific article published on 04 February 2019

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

artículo científico publicado en 2014

Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations

artículo científico publicado en 2003

Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.

artículo científico publicado en 2015

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

scientific article published on 02 May 2019

The structure of FADD and its mode of interaction with procaspase-8

scientific article published on 01 June 2006

Tracking BAX once its trigger is pulled ⬇️

artículo científico publicado el 15 de marzo de 2011

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Evripidis Gavathiotis

A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival ⬇️

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

An interconnected hierarchical model of cell death regulation by the BCL-2 family

BAX activation is initiated at a novel interaction site

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

Chemical genetics: Unraveling cell death mysteries.

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study ⬇️

Correcting mitochondrial fusion by manipulating mitofusin conformations

Current Insights of BRAF Inhibitors in Cancer.

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

Direct and selective small-molecule activation of proapoptotic BAX

Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

Editorial overview: Chemical genetics and epigenetics.

Eltrombopag directly inhibits BAX and prevents cell death

Erratum: Corrigendum: Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

ICBS 2017 in Shanghai-Illuminating Life with Chemical Innovation.

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Inhibitors of BRAF dimers using an allosteric site

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3

New perspectives for targeting RAF kinase in human cancer.

Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1

Pharmacological inhibition of the transcription factor PU.1 in leukemia

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

Progress in targeting the BCL-2 family of proteins.

Pulling the BAX trigger for tumor cell death.

Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4

Self-regulation of BAX-induced cell death.

Small-molecule allosteric inhibitors of BAX

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations

Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

The structure of FADD and its mode of interaction with procaspase-8

Tracking BAX once its trigger is pulled ⬇️

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)