Lista de obras - Hagit Eldar-Finkelman - Dominio Público Uruguay

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

artículo científico publicado en 2016

Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment

artículo científico publicado en 2003

Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth

artículo científico publicado en 2014

Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue

artículo científico publicado en 2008

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors

artículo científico publicado en 2013

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

artículo científico publicado en 2020

Distinct molecular regulation of glycogen synthase kinase-3alpha isozyme controlled by its N-terminal region: functional role in calcium/calpain signaling

artículo científico publicado en 2011

Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor

artículo científico publicado en 2011

Exploiting substrate recognition for selective inhibition of protein kinases

artículo científico publicado en 2012

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS ⬇️

artículo científico publicado el 31 de octubre de 2011

GSK-3 and lysosomes meet in Alzheimer's disease

artículo científico publicado en 2013

GSK-3 inhibition: achieving moderate efficacy with high selectivity

artículo científico

GSK-3β Inhibition Affects Singing Behavior and Neurogenesis in Adult Songbirds

artículo científico publicado en 2015

GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer

artículo científico publicado en 2010

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.

artículo científico publicado en 2010

Glycogen synthase kinase 3: an emerging therapeutic target

artículo científico publicado en 2002

Glycogen synthase kinase-3--a promising therapeutic target: Dr Hagit Eldar-Finkelman interviewed by Emma Quigley

artículo científico publicado en 2006

Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3.

artículo científico publicado en 2010

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

artículo científico publicado en 2012

Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition

artículo científico publicado en 2006

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice

artículo científico publicado en 2003

Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

artículo científico publicado en 2012

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc

artículo científico publicado en 2002

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.

artículo científico publicado en 2003

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

artículo científico publicado en 2017

Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.

artículo científico publicado en 2016

Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha

artículo científico publicado en 2004

Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle

artículo científico publicado en 2005

Monitor and Molecules

artículo científico publicado en 2001

New insights into the autoinhibition mechanism of glycogen synthase kinase-3beta

artículo científico publicado en 2008

Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner.

artículo científico publicado en 2008

PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase

artículo científico publicado en 2004

Peptide inhibitors targeting protein kinases

artículo científico publicado en 2009

Peptides targeting protein kinases: strategies and implications

artículo científico publicado en 2006

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action ⬇️

artículo científico publicado el 2 de septiembre de 1997

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

artículo científico publicado en 2004

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

artículo científico publicado en 2013

Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.

artículo científico publicado en 2006

Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor

artículo científico publicado en 2016

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

scholarly article by Lina Tsaadon Alon published in March 2011

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

artículo científico publicado en 2007

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling

artículo científico publicado en 2004

Structure-based optimization of oxadiazole-based GSK-3 inhibitors

artículo científico publicado en 2012

Substrate competitive GSK-3 inhibitors - strategy and implications

artículo científico publicado en 2009

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.

artículo científico publicado en 2011

The SIL gene is essential for mitotic entry and survival of cancer cells.

artículo científico publicado en 2007

The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes

artículo científico publicado en 2002

Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition

artículo científico publicado en 2016

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

artículo científico publicado en 2011

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Hagit Eldar-Finkelman

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment

Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth

Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

Distinct molecular regulation of glycogen synthase kinase-3alpha isozyme controlled by its N-terminal region: functional role in calcium/calpain signaling

Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor

Exploiting substrate recognition for selective inhibition of protein kinases

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS ⬇️

GSK-3 and lysosomes meet in Alzheimer's disease

GSK-3 inhibition: achieving moderate efficacy with high selectivity

GSK-3β Inhibition Affects Singing Behavior and Neurogenesis in Adult Songbirds

GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.

Glycogen synthase kinase 3: an emerging therapeutic target

Glycogen synthase kinase-3--a promising therapeutic target: Dr Hagit Eldar-Finkelman interviewed by Emma Quigley

Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3.

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice

Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.

Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha

Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle

Monitor and Molecules

New insights into the autoinhibition mechanism of glycogen synthase kinase-3beta

Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner.

PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase

Peptide inhibitors targeting protein kinases

Peptides targeting protein kinases: strategies and implications

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action ⬇️

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.

Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling

Structure-based optimization of oxadiazole-based GSK-3 inhibitors

Substrate competitive GSK-3 inhibitors - strategy and implications

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.

The SIL gene is essential for mitotic entry and survival of cancer cells.

The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes

Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)