Lista de obras - Klaus Gerwert - Dominio Público Uruguay

A delocalized proton-binding site within a membrane protein

artículo científico publicado en 2014

A method for the comparison of multi-platform spectral histopathology (SHP) data sets

artículo científico publicado en 2015

A modified infrared spectrometer with high time resolution and its application for investigating fast conformational changes of the GTPase Ras.

artículo científico publicado en 2014

A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein

artículo científico publicado en 2006

Amyloid blood biomarker detects Alzheimer's disease

artículo científico publicado en 2018

Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer's Disease

artículo científico publicado en 2016

An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids

artículo científico publicado en 2015

Biofluids and other techniques: general discussion

artículo científico publicado en 2016

Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy

artículo científico publicado en 2015

Catalytic mechanism of a mammalian Rab⋅RabGAP complex in atomic detail

artículo científico publicado en 2012

Channelrhodopsin reveals its dark secrets

artículo científico publicado en 2017

Clinical Spectroscopy: general discussion

artículo científico publicado en 2016

Colocalization of fluorescence and Raman microscopic images for the identification of subcellular compartments: a validation study

artículo científico publicado en 2015

Coupling of light-induced electron transfer to proton uptake in photosynthesis

artículo científico publicado en 2003

De novo design of conformationally flexible transmembrane peptides driving membrane fusion

scholarly article

Design of an Ultrafast G Protein Switch Based on a Mouse Melanopsin Variant

scientific article published on 18 June 2019

Directional proton transfer in membrane proteins achieved through protonated protein-bound water molecules: a proton diode

artículo científico publicado en 2010

Does different orientation of the methoxy groups of ubiquinone-10 in the reaction centre of Rhodobacter sphaeroides cause different binding at QA and QB?

artículo científico publicado en 2003

Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR).

artículo científico publicado en 2017

Dynamics of water molecules in the bacteriorhodopsin trimer in explicit lipid/water environment

artículo científico publicado en 2004

Early formation of the ion-conducting pore in channelrhodopsin-2.

artículo científico publicado en 2014

Elucidation of Single Hydrogen Bonds in GTPases via Experimental and Theoretical Infrared Spectroscopy

artículo científico publicado en 2017

Exploring the Multidimensional Free Energy Surface of Phosphoester Hydrolysis with Constrained QM/MM Dynamics

artículo científico publicado en 2012

FTIR spectroscopy of biofluids revisited: an automated approach to spectral biomarker identification ⬇️

artículo científico publicado el 28 de mayo de 2013

Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger

artículo científico publicado en 2004

Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy

artículo científico publicado en 2005

Hierarchical deep convolutional neural networks combine spectral and spatial information for highly accurate Raman-microscopy-based cytopathology

scholarly article by Sascha D Krauß et al published 21 May 2018 in Journal of Biophotonics

Histidine is involved in coupling proton uptake to electron transfer in photosynthetic proteins ⬇️

artículo científico publicado el 8 de octubre de 2010

How Does a Membrane Protein Achieve a Vectorial Proton Transfer Via Water Molecules?

IR Spectra of Phosphate Ions in Aqueous Solution: Predictions of a DFT/MM Approach Compared with Observations

article published in 2004

Immunohistochemistry, histopathology and infrared spectral histopathology of colon cancer tissue sections

artículo científico publicado en 2012

In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle

artículo científico publicado en 2012

In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging

artículo científico publicado en 2015

Infrared spectral marker bands characterizing a transient water wire inside a hydrophobic membrane protein

Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach

It's in your blood: spectral biomarker candidates for urinary bladder cancer from automated FTIR spectroscopy

artículo científico publicado en 2014

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells

artículo científico publicado en 2015

Label-free identification of myopathological features with coherent anti-Stokes Raman scattering

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

artículo científico publicado en 2014

Label-free screening of drug-protein interactions by time-resolved Fourier transform infrared spectroscopic assays exemplified by Ras interactions

artículo científico publicado en 2010

Ligand-Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free-Towards a Conformational Activity Screening for Drug Discovery

scientific article published on 03 July 2018

Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy

artículo científico publicado en 2005

Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging

artículo científico publicado en 2015

Monitoring protein-ligand interactions by time-resolved FTIR difference spectroscopy

artículo científico publicado en 2005

Monitoring transient events in infrared spectra using local mode analysis

scientific article published on 29 October 2018

N-Ras forms dimers at POPC membranes

artículo científico publicado en 2012

Prediction of a Ligand-Binding Niche within a Human Olfactory Receptor by Combining Site-Directed Mutagenesis with Dynamic Homology Modeling

article

Prion protein alpha-to-beta transition monitored by time-resolved Fourier transform infrared spectroscopy

artículo científico publicado en 2007

Proteins in action monitored by time-resolved FTIR spectroscopy

artículo científico publicado en 2005

Proton binding within a membrane protein by a protonated water cluster

artículo científico publicado en 2005

Proton transfer via a transient linear water-molecule chain in a membrane protein

artículo científico publicado en 2011

Quantum Cascade Laser-Based Infrared Microscopy for Label-Free and Automated Cancer Classification in Tissue Sections

artículo científico publicado en 2018

Raman Micro-Spectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells.

artículo científico publicado en 2018

Raman-mikrospektroskopischer Nachweis für den Metabolismus eines Tyrosinkinase-Inhibitors, Neratinib, in Krebszellen

Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations

artículo científico publicado en 2012

Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy

artículo científico publicado en 2014

Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations

artículo científico publicado en 2007

Secondary structure of lipidated Ras bound to a lipid bilayer

artículo científico publicado en 2008

Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site

artículo científico publicado en 2008

Single cell analysis/data handling: general discussion

artículo científico publicado en 2016

Spectral Pathology: general discussion

artículo científico publicado en 2016

Spectral histopathology of colon cancer tissue sections by Raman imaging with 532 nm excitation provides label free annotation of lymphocytes, erythrocytes and proliferating nuclei of cancer cells

artículo científico publicado en 2013

Spectroscopic investigation of the reaction mechanism of CopB-B, the catalytic fragment from an archaeal thermophilic ATP-driven heavy metal transporter

artículo científico publicado en 2009

Structural basis of slow activation gating in the cardiac I Ks channel complex

artículo científico publicado en 2011

Structural changes of membrane-anchored native PrP(C)

artículo científico publicado en 2008

Surface-Attached Polyhistidine-Tag Proteins Characterized by FTIR Difference Spectroscopy

artículo científico publicado en 2012

Systematic approach to group-specific isotopic labeling of proteins for vibrational spectroscopy

article

The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

artículo científico publicado en 2008

The Ras dimer structure

artículo científico publicado en 2021

The assignment of the different infrared continuum absorbance changes observed in the 3000-1800-cm(-1) region during the bacteriorhodopsin photocycle

artículo científico publicado en 2004

The dynamics of the catalytic site in small GTPases, variations on a common motif

artículo científico

The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations

artículo científico publicado en 2012

The role of protein-bound water molecules in microbial rhodopsins

artículo científico publicado en 2014

The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays ⬇️

artículo científico publicado el 21 de octubre de 2011

Theoretical IR spectroscopy based on QM/MM calculations provides changes in charge distribution, bond lengths, and bond angles of the GTP ligand induced by the Ras-protein

artículo científico publicado en 2005

Time-resolved FTIR spectroscopy for monitoring protein dynamics exemplified by functional studies of Ras protein bound to a lipid bilayer

article

Time-resolved FTIR studies provide activation free energy, activation enthalpy and activation entropy for GTPase reactions

Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle

artículo científico publicado en 2012

Tyr39 of ran preserves the Ran.GTP gradient by inhibiting GTP hydrolysis

artículo científico publicado en 2010

Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2

scientific article published on 19 April 2019

Unraveling the Phosphocholination Mechanism of the Legionella pneumophila Enzyme AnkX.

artículo científico publicado en 2016

Unravelling the mechanism of dual-specificity GAPs

artículo científico publicado en 2010

Water dynamics simulation as a tool for probing proton transfer pathways in a heptahelical membrane protein

artículo científico publicado en 2005

What vibrations tell us about GTPases

artículo científico publicado en 2015

Zeitaufgelöst und markerfrei gemessene ligandeninduzierte Konformationsänderungen von HSP90 - hin zu einem Konformationsaktivitätsscreening für die Wirkstoffentwicklung

pKa calculations suggest storage of an excess proton in a hydrogen-bonded water network in bacteriorhodopsin

artículo científico publicado en 2001

Lista de obras de Klaus Gerwert

A delocalized proton-binding site within a membrane protein

A method for the comparison of multi-platform spectral histopathology (SHP) data sets

A modified infrared spectrometer with high time resolution and its application for investigating fast conformational changes of the GTPase Ras.

A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein

Amyloid blood biomarker detects Alzheimer's disease

Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer's Disease

An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids

Biofluids and other techniques: general discussion

Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy

Catalytic mechanism of a mammalian Rab⋅RabGAP complex in atomic detail

Channelrhodopsin reveals its dark secrets

Clinical Spectroscopy: general discussion

Colocalization of fluorescence and Raman microscopic images for the identification of subcellular compartments: a validation study

Coupling of light-induced electron transfer to proton uptake in photosynthesis

De novo design of conformationally flexible transmembrane peptides driving membrane fusion

Design of an Ultrafast G Protein Switch Based on a Mouse Melanopsin Variant

Directional proton transfer in membrane proteins achieved through protonated protein-bound water molecules: a proton diode

Does different orientation of the methoxy groups of ubiquinone-10 in the reaction centre of Rhodobacter sphaeroides cause different binding at QA and QB?

Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR).

Dynamics of water molecules in the bacteriorhodopsin trimer in explicit lipid/water environment

Early formation of the ion-conducting pore in channelrhodopsin-2.

Elucidation of Single Hydrogen Bonds in GTPases via Experimental and Theoretical Infrared Spectroscopy

Exploring the Multidimensional Free Energy Surface of Phosphoester Hydrolysis with Constrained QM/MM Dynamics

FTIR spectroscopy of biofluids revisited: an automated approach to spectral biomarker identification ⬇️

Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger

Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy

Hierarchical deep convolutional neural networks combine spectral and spatial information for highly accurate Raman-microscopy-based cytopathology

Histidine is involved in coupling proton uptake to electron transfer in photosynthetic proteins ⬇️

How Does a Membrane Protein Achieve a Vectorial Proton Transfer Via Water Molecules?

IR Spectra of Phosphate Ions in Aqueous Solution: Predictions of a DFT/MM Approach Compared with Observations

Immunohistochemistry, histopathology and infrared spectral histopathology of colon cancer tissue sections

In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle

In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging

Infrared spectral marker bands characterizing a transient water wire inside a hydrophobic membrane protein

Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach

It's in your blood: spectral biomarker candidates for urinary bladder cancer from automated FTIR spectroscopy

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells

Label-free identification of myopathological features with coherent anti-Stokes Raman scattering

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

Label-free screening of drug-protein interactions by time-resolved Fourier transform infrared spectroscopic assays exemplified by Ras interactions

Ligand-Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free-Towards a Conformational Activity Screening for Drug Discovery

Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy

Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging

Monitoring protein-ligand interactions by time-resolved FTIR difference spectroscopy

Monitoring transient events in infrared spectra using local mode analysis

N-Ras forms dimers at POPC membranes

Prediction of a Ligand-Binding Niche within a Human Olfactory Receptor by Combining Site-Directed Mutagenesis with Dynamic Homology Modeling

Prion protein alpha-to-beta transition monitored by time-resolved Fourier transform infrared spectroscopy

Proteins in action monitored by time-resolved FTIR spectroscopy

Proton binding within a membrane protein by a protonated water cluster

Proton transfer via a transient linear water-molecule chain in a membrane protein

Quantum Cascade Laser-Based Infrared Microscopy for Label-Free and Automated Cancer Classification in Tissue Sections

Raman Micro-Spectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells.

Raman-mikrospektroskopischer Nachweis für den Metabolismus eines Tyrosinkinase-Inhibitors, Neratinib, in Krebszellen

Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations

Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy

Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations

Secondary structure of lipidated Ras bound to a lipid bilayer

Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site

Single cell analysis/data handling: general discussion

Spectral Pathology: general discussion

Spectral histopathology of colon cancer tissue sections by Raman imaging with 532 nm excitation provides label free annotation of lymphocytes, erythrocytes and proliferating nuclei of cancer cells

Spectroscopic investigation of the reaction mechanism of CopB-B, the catalytic fragment from an archaeal thermophilic ATP-driven heavy metal transporter

Structural basis of slow activation gating in the cardiac I Ks channel complex

Structural changes of membrane-anchored native PrP(C)

Surface-Attached Polyhistidine-Tag Proteins Characterized by FTIR Difference Spectroscopy

Systematic approach to group-specific isotopic labeling of proteins for vibrational spectroscopy

The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

The Ras dimer structure

The assignment of the different infrared continuum absorbance changes observed in the 3000-1800-cm(-1) region during the bacteriorhodopsin photocycle

The dynamics of the catalytic site in small GTPases, variations on a common motif

The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations

The role of protein-bound water molecules in microbial rhodopsins

The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays ⬇️

Theoretical IR spectroscopy based on QM/MM calculations provides changes in charge distribution, bond lengths, and bond angles of the GTP ligand induced by the Ras-protein

Time-resolved FTIR spectroscopy for monitoring protein dynamics exemplified by functional studies of Ras protein bound to a lipid bilayer

Time-resolved FTIR studies provide activation free energy, activation enthalpy and activation entropy for GTPase reactions

Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle

Tyr39 of ran preserves the Ran.GTP gradient by inhibiting GTP hydrolysis