Lista de obras - Shehab A Ismail - Dominio Público Uruguay

A GDI/GDF-like system for sorting and shuttling ciliary proteins

artículo científico publicado en 2016

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

artículo científico publicado en 2017

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB.

artículo científico publicado en 2017

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition

artículo científico publicado en 2018

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

artículo científico publicado en 2021

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

artículo científico publicado en 2011

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site

artículo científico publicado en 2016

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

artículo científico publicado en 2015

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

artículo científico publicado en 2018

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

artículo científico publicado en 2019

Identification of pyrazolopyridazinones as PDEδ inhibitors

artículo científico publicado en 2016

Maintaining protein composition in cilia

artículo científico publicado en 2017

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

artículo científico publicado en 2016

Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives

artículo científico publicado en 2014

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

artículo científico publicado en 2017

Shuttling and sorting lipid-modified cargo into the cilia.

artículo científico publicado en 2016

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

artículo científico publicado en 2013

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

artículo científico publicado en 2008

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

artículo científico publicado en 2012

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site

artículo científico publicado en 2014

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK

artículo científico publicado en 2018

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

artículo científico publicado en 2011

The N- and C-terminal ends of RPGR can bind to PDE6δ.

artículo científico publicado en 2015

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

artículo científico publicado en 2013

The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism

artículo científico publicado en 2010

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

artículo científico publicado en 2017

Lista de obras de Shehab A Ismail

A GDI/GDF-like system for sorting and shuttling ciliary proteins

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB.

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

Identification of pyrazolopyridazinones as PDEδ inhibitors

Maintaining protein composition in cilia

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Shuttling and sorting lipid-modified cargo into the cilia.

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

The N- and C-terminal ends of RPGR can bind to PDE6δ.

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.