Lista de obras - Edwin R Chapman - Dominio Público Uruguay

A Ca2+ Sensor for Exocytosis

artículo científico publicado en 2018

A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores

artículo científico publicado en 2015

Activation of postsynaptic Ca(2+) stores modulates glutamate receptor cycling in hippocampal neurons

artículo científico publicado en 2005

Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

artículo científico publicado en 2020

An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.

artículo científico publicado en 2015

Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms

scientific journal article

Application of fluorescent probes to study mechanics and dynamics of Ca2+-triggered synaptotagmin C2 domain-membrane interactions

artículo científico publicado en 2003

Atomic force microscope spectroscopy reveals a hemifusion intermediate during soluble N-ethylmaleimide-sensitive factor-attachment protein receptors-mediated membrane fusion

artículo científico publicado en 2007

Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.

artículo científico publicado en 2009

Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen

artículo científico publicado en 2012

Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH

artículo científico publicado en 2012

Botulinum toxin type B micromechanosensor

artículo científico publicado en 2003

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

artículo científico publicado en 2002

CAPS Acts at a Prefusion Step in Dense-Core Vesicle Exocytosis as a PIP2 Binding Protein

artículo científico publicado en 2004

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

artículo científico publicado en 2006

Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

artículo científico publicado en 1995

Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo

artículo científico publicado en 2008

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission

artículo científico publicado en 2012

Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells

artículo científico publicado en 2010

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

artículo científico publicado en 2010

Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin

scientific journal article

Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I.

artículo científico publicado en 2012

Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.

artículo científico publicado en 2019

Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm

artículo científico publicado en 2015

Different domains of synaptotagmin control the choice between kiss-and-run and full fusion.

artículo científico publicado en 2003

Different states of synaptotagmin regulate evoked versus spontaneous release

artículo científico publicado en 2016

Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers ⬇️

artículo científico publicado el 29 de mayo de 1998

Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules

artículo científico publicado en 2014

Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity

artículo científico publicado en 2012

Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.

artículo científico publicado en 2011

Doc2-mediated superpriming supports synaptic augmentation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation

artículo científico publicado en 2000

Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties.

artículo científico publicado en 2018

ENaC subunit-subunit interactions and inhibition by syntaxin 1A

artículo científico publicado en 2004

ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously.

artículo científico publicado en 2010

Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release.

artículo científico publicado en 2018

Exocytotic fusion pores are composed of both lipids and proteins

artículo científico publicado en 2015

Fatty acylation of synaptotagmin in PC12 cells and synaptosomes.

artículo científico publicado en 1996

Fluorescence energy transfer analysis of calmodulin-peptide complexes

artículo científico publicado en 1992

Functional Domains of Neuromodulin and the Interaction of Calmodulin with Target Peptides ⬇️

doctoral thesis by Edwin R. Chapman, 1992

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.

artículo científico publicado en 2016

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

artículo científico publicado en 2004

Fusion pores and fusion machines in Ca2+-triggered exocytosis.

artículo científico publicado en 2006

G.I. Joe

print in the National Gallery of Art (NGA 32639)

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

artículo científico publicado en 2008

Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles

artículo científico publicado en 2012

Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes

artículo científico publicado en 2017

Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells

scientific journal article

Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation

artículo científico publicado en 2016

Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure

artículo científico publicado en 2013

Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons.

artículo científico publicado en 2016

Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

artículo científico publicado en 1999

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission

artículo científico publicado en 2014

Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopy

artículo científico publicado en 1998

Lipid mixing and content release in single-vesicle, SNARE-driven fusion assay with 1-5 ms resolution

artículo científico publicado en 2009

Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.

artículo científico publicado en 2015

MARCKS-ED peptide as a curvature and lipid sensor

artículo científico publicado en 2012

Mechanism and function of synaptotagmin-mediated membrane apposition

artículo científico publicado en 2011

Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo

artículo científico publicado en 2011

Membrane-embedded synaptotagmin penetrates cis or trans target membranes and clusters via a novel mechanism

scientific article published on 01 August 2000

Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder

scientific article published on 21 April 2020

Molecular regulation of membrane resealing in 3T3 fibroblasts.

artículo científico publicado en 2004

Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles

artículo científico publicado en 2013

Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner

artículo científico publicado en 2003

Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission

artículo científico publicado en 2013

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion ⬇️

artículo científico publicado el 4 de octubre de 2010

Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

artículo científico publicado en 2018

Permeation of styryl dyes through nanometer-scale pores in membranes

artículo científico publicado en 2011

Phosphatidylinositol 4,5-bisphosphate drives Ca2+-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β

artículo científico publicado en 2019

Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells.

artículo científico publicado en 2009

Poisoning by botulinum neurotoxin A does not inhibit formation or disassembly of the synaptosomal fusion complex.

artículo científico publicado en 1995

Postsynaptic Neuroligin1 regulates presynaptic maturation

scientific journal article

Productive hemifusion intermediates in fast vesicle fusion driven by neuronal SNAREs.

artículo científico publicado en 2007

Programmable Nanodisc Patterning by DNA Origami

artículo científico publicado en 2020

Pulling force generated by interacting SNAREs facilitates membrane hemifusion.

artículo científico publicado en 2009

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

artículo científico publicado en 2020

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion

scientific journal article

Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.

artículo científico publicado en 2011

Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.

artículo científico publicado en 2004

Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells

scientific journal article

Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores

scientific article published on 13 January 2020

Retargeted clostridial neurotoxins as novel agents for treating chronic diseases.

artículo científico publicado en 2011

SNAP-23 functions in docking/fusion of granules at low Ca2+.

artículo científico publicado en 2004

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion

artículo científico publicado en 2001

SV2 is the protein receptor for botulinum neurotoxin A.

artículo científico publicado en 2006

Sar1 GTPase Activity Is Regulated by Membrane Curvature.

artículo científico publicado en 2015

Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9.

artículo científico publicado en 2015

Single molecule mechanical probing of the SNARE protein interactions

artículo científico publicado en 2006

Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR

artículo científico publicado en 2018

Structural basis of cell surface receptor recognition by botulinum neurotoxin B

artículo científico publicado en 2006

Structural elements that underlie Doc2β function during asynchronous synaptic transmission.

artículo científico publicado en 2015

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin

artículo científico publicado en 2019

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

artículo científico publicado en 2019

Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment

scientific journal article

Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis

artículo científico publicado en 2008

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

artículo científico publicado en 2008

Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules.

artículo científico publicado en 2017

Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion

artículo científico publicado en 2005

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.

artículo científico publicado en 2016

Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation

scientific article published on 17 November 2005

Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release

scientific journal article

Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

scientific journal article

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells ⬇️

artículo científico publicado el 22 de septiembre de 2003

Syntaxin Requirement for Ca2+-Triggered Exocytosis in Neurons and Endocrine Cells Demonstrated with an Engineered Neurotoxin ⬇️

artículo científico publicado el 18 de marzo de 2011

Targeting of neuromodulin (GAP-43) fusion proteins to growth cones in cultured rat embryonic neurons ⬇️

artículo científico publicado el 1 de marzo de 1991

The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

artículo científico publicado en 2017

The fusion pores of Ca2+ -triggered exocytosis

artículo científico publicado en 2008

The neuronal exocytotic fusion machine: some new developments.

artículo científico publicado en 1995

The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion.

artículo científico publicado en 2018

The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.

artículo científico publicado en 2001

Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis.

artículo científico publicado en 2005

Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.

artículo científico publicado en 2004

Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity.

artículo científico publicado en 2016

Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.

artículo científico publicado en 2011

Visualization of synaptotagmin I oligomers assembled onto lipid monolayers.

artículo científico publicado en 2003

Lista de obras de Edwin R Chapman

A Ca2+ Sensor for Exocytosis

A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores

Activation of postsynaptic Ca(2+) stores modulates glutamate receptor cycling in hippocampal neurons

Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.

Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms

Application of fluorescent probes to study mechanics and dynamics of Ca2+-triggered synaptotagmin C2 domain-membrane interactions

Atomic force microscope spectroscopy reveals a hemifusion intermediate during soluble N-ethylmaleimide-sensitive factor-attachment protein receptors-mediated membrane fusion

Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.

Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen

Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH

Botulinum toxin type B micromechanosensor

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

CAPS Acts at a Prefusion Step in Dense-Core Vesicle Exocytosis as a PIP2 Binding Protein

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission

Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin

Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I.

Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.

Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm

Different domains of synaptotagmin control the choice between kiss-and-run and full fusion.

Different states of synaptotagmin regulate evoked versus spontaneous release

Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers ⬇️

Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules

Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity

Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.

Doc2-mediated superpriming supports synaptic augmentation

Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation

Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties.

ENaC subunit-subunit interactions and inhibition by syntaxin 1A

ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously.

Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release.

Exocytotic fusion pores are composed of both lipids and proteins

Fatty acylation of synaptotagmin in PC12 cells and synaptosomes.

Fluorescence energy transfer analysis of calmodulin-peptide complexes

Functional Domains of Neuromodulin and the Interaction of Calmodulin with Target Peptides ⬇️

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

Fusion pores and fusion machines in Ca2+-triggered exocytosis.

G.I. Joe

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles

Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes

Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells

Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation

Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure

Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons.

Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission

Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopy

Lipid mixing and content release in single-vesicle, SNARE-driven fusion assay with 1-5 ms resolution

Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.

MARCKS-ED peptide as a curvature and lipid sensor

Mechanism and function of synaptotagmin-mediated membrane apposition

Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo

Membrane-embedded synaptotagmin penetrates cis or trans target membranes and clusters via a novel mechanism

Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder

Molecular regulation of membrane resealing in 3T3 fibroblasts.

Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles

Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner

Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion ⬇️

Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

Permeation of styryl dyes through nanometer-scale pores in membranes

Phosphatidylinositol 4,5-bisphosphate drives Ca2+-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β

Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells.

Poisoning by botulinum neurotoxin A does not inhibit formation or disassembly of the synaptosomal fusion complex.

Postsynaptic Neuroligin1 regulates presynaptic maturation

Productive hemifusion intermediates in fast vesicle fusion driven by neuronal SNAREs.

Programmable Nanodisc Patterning by DNA Origami

Pulling force generated by interacting SNAREs facilitates membrane hemifusion.

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion

Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.

Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.