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Lista de obras de Darren J Kelly

3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.

artículo científico publicado en 2013

3′,4′-Dihydroxyflavonol Antioxidant Attenuates Diastolic Dysfunction and Cardiac Remodeling in Streptozotocin-Induced Diabetic m(Ren2)27 Rats ⬇️

artículo científico publicado el 28 de julio de 2011

A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction

artículo científico publicado en 2012

A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat

artículo científico publicado en 2012

Adrenaline cells of the rat adrenal cortex and medulla contain renin and prorenin

scientific article published on 01 May 1996

Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?

artículo científico publicado en 2007

Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart

artículo científico publicado en 2011

Angiotensin II-induced proteinuria and expression of the podocyte slit pore membrane protein, nephrin

artículo científico publicado en 2004

Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes

artículo científico publicado en 2000

Atrial Remodeling in an Ovine Model of Anthracycline-Induced Nonischemic Cardiomyopathy: Remodeling of the Same Sort

artículo científico publicado en 2011

Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing

artículo científico publicado en 2013

Atrial protective effects of n-3 polyunsaturated fatty acids: a long-term study in ovine chronic heart failure

artículo científico publicado en 2010

Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011

artículo científico publicado en 2012

BK virus RNA can be detected in archival renal transplant biopsies using the reverse trancription polymerase chain reaction.

artículo científico

COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity

artículo científico publicado en 2003

Cannabinoid receptor 2 expression in human proximal tubule cells is regulated by albumin independent of ERK1/2 signaling

artículo científico publicado en 2013

Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart

artículo científico publicado en 2015

Cardiac fibrosis in the ageing heart: contributors and mechanisms.

artículo científico publicado en 2017

Cells expressing the stem cell factor receptor, c-kit, contribute to neoangiogenesis in diabetes

artículo científico publicado en 2005

Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model

artículo científico publicado en 2010

Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis

scientific article published on 13 January 2015

Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats

artículo científico publicado en 2016

Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy.

artículo científico publicado en 2010

Clinically relevant models of diabetic cardiac complications

scientific article published on 01 September 2007

Contribution of microRNA to pathological fibrosis in cardio-renal syndrome: impact of uremic toxins

artículo científico publicado en 2015

Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism

artículo científico publicado en 2010

Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels

artículo científico publicado en 2012

Differences in myocardial structure and coronary microvasculature between men and women with coronary artery disease

scientific article published on 06 December 2010

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

artículo científico publicado en 2021

Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo

scientific article published on 10 November 2011

Early and delayed tranilast treatment reduces pathological fibrosis following myocardial infarction.

artículo científico publicado en 2012

Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction.

artículo científico publicado en 2009

Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat

scientific article published on 01 May 2000

Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy

scientific article published on 23 May 2007

Elevated cannabinoid receptor 1 and G protein-coupled receptor 55 expression in proximal tubule cells and whole kidney exposed to diabetic conditions.

artículo científico publicado en 2015

Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates

artículo científico publicado en 2009

Expression, localization, and function of the thioredoxin system in diabetic nephropathy

artículo científico publicado en 2009

FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy

artículo científico publicado en 2015

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy

artículo científico publicado en 2012

FT23, an orally active antifibrotic compound, attenuates structural and functional abnormalities in an experimental model of diabetic cardiomyopathy

artículo científico publicado en 2012

Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: attenuation with renin-angiotensin blockade

artículo científico publicado en 2004

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease

artículo científico publicado en 2015

Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat

artículo científico publicado en 2007

High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.

artículo científico publicado en 2008

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

artículo científico publicado en 2014

High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism

artículo científico publicado en 2007

High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1.

artículo científico publicado en 2007

Hypertension and atrial fibrillation: evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model

artículo científico publicado en 2010

Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease

artículo científico publicado en 2011

Impaired cardiac anti-oxidant activity in diabetes: human and correlative experimental studies

artículo científico publicado en 2014

In vivo visualization of albumin degradation in the proximal tubule

artículo científico publicado en 2008

Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy

artículo científico publicado en 2004

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

artículo científico publicado en 2005

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

scientific article published on 10 February 2009

Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy ⬇️

artículo científico publicado el 1 de agosto de 2011

Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy

scientific article published on 01 January 2003

Macrophage infiltration and cellular proliferation in the non-ischemic kidney and heart following prolonged unilateral renal ischemia

scientific article published on 15 June 2007

Mast cell infiltration and chemokine expression in progressive renal disease

artículo científico publicado en 2003

Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome

artículo científico publicado en 2012

Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis

artículo científico publicado en 2004

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

artículo científico publicado en 2018

Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation

artículo científico publicado en 2012

PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis.

artículo científico publicado en 2001

Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats.

artículo científico publicado en 2008

Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo.

artículo científico publicado en 2004

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

artículo científico publicado en 2003

Protein kinase C β inhibition ameliorates experimental mesangial proliferative glomerulonephritis.

artículo científico publicado en 2011

Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease

artículo científico publicado en 2009

Protein kinase Cbeta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy

artículo científico publicado en 2005

Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.

artículo científico publicado en 2011

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

artículo científico publicado en 2008

Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy

artículo científico publicado en 2006

Renal expression of transforming growth factor-β inducible gene-h3 (βig-h3) in normal and diabetic rats11See Editorial by Border and Noble, p. 1390

article

Renin inhibition: new potential for an old therapeutic target

artículo científico publicado en 2005

Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells

artículo científico publicado en 2008

Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions

artículo científico publicado en 2007

Role of the eNOS-NO system in regulating the antiproteinuric effects of VEGF receptor 2 inhibition in diabetes

artículo científico publicado en 2013

SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity

scientific journal article

Short-term hypertension is associated with the development of atrial fibrillation substrate: a study in an ovine hypertensive model.

artículo científico publicado en 2009

Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction

artículo científico publicado en 2012

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction

artículo científico publicado en 2010

Targeting Fibrosis for the Treatment of Heart Failure: A Role for Transforming Growth Factor‐β ⬇️

artículo científico publicado el 23 de septiembre de 2010

The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes

scientific article published on 01 September 2013

The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1.

artículo científico

The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-γ in the regulation of macrophage inflammatory protein-3α at early onset of diabetes ⬇️

artículo científico publicado el 23 de noviembre de 2010

The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction

artículo científico publicado en 2013

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway.

artículo científico publicado en 2016

Thioredoxin-interacting protein: a potential therapeutic target for treatment of progressive fibrosis in diabetic nephropathy.

artículo científico publicado en 2015

Tranilast ameliorates experimental mesangial proliferative glomerulonephritis

artículo científico publicado en 2008

Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta

artículo científico publicado en 2005

Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy

scientific article published on 24 August 2007

Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model

artículo científico publicado en 2004

Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy.

artículo científico publicado en 2010

Transforming growth factor-beta in human diabetic nephropathy: effects of ACE inhibition.

artículo científico publicado en 2006

Vasoactive renal factors and the progression of diabetic nephropathy.

artículo científico publicado en 2004

Vitamin D(2) supplementation induces the development of aortic stenosis in rabbits: interactions with endothelial function and thioredoxin-interacting protein.

artículo científico publicado en 2008

Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model

artículo científico publicado en 2017

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