Lista de obras - Andrew J Knox - Dominio Público Uruguay

'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators.

artículo científico publicado en 2010

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.

artículo científico publicado en 2007

Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells

scientific article published on 01 October 2008

Considerations in compound database preparation--"hidden" impact on virtual screening results.

artículo científico publicado en 2005

Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells.

artículo científico publicado en 2016

Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.

artículo científico publicado en 2007

Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.

artículo científico publicado en 2010

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

scientific article published on 01 May 2017

Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.

artículo científico publicado en 2010

Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.

artículo científico publicado en 2010

Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.

artículo científico publicado en 2011

On the effects of permuted input on conformational sampling of drug-like molecules: an evaluation of stochastic proximity embedding.

artículo científico publicado en 2007

Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening

scientific article published on 24 December 2019

Permuting input for more effective sampling of 3D conformer space.

artículo científico publicado en 2006

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

artículo científico publicado en 2014

Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.

artículo científico publicado en 2010

Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.

artículo científico publicado en 2011

Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.

artículo científico publicado en 2008

Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening

artículo científico publicado en 2012

Unbiasing scoring functions: a new normalization and rescoring strategy

artículo científico publicado en 2007

Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation.

artículo científico publicado en 2013

Virtual screening of the estrogen receptor.

artículo científico publicado en 2008

β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.

artículo científico publicado en 2014

Lista de obras de Andrew J Knox

'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators.

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.

Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells

Considerations in compound database preparation--"hidden" impact on virtual screening results.

Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells.

Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.

Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.

Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.

Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.

On the effects of permuted input on conformational sampling of drug-like molecules: an evaluation of stochastic proximity embedding.

Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening

Permuting input for more effective sampling of 3D conformer space.

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.

Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.

Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.

Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening

Unbiasing scoring functions: a new normalization and rescoring strategy

Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation.

Virtual screening of the estrogen receptor.

β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.