Lista de obras - Kimberly Stegmaier - Dominio Público Uruguay

A first-generation pediatric cancer dependency map

artículo científico publicado en 2021

A method for high-throughput gene expression signature analysis

artículo científico publicado en 2006

A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia

artículo científico publicado en 2013

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

artículo científico publicado en 2014

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regu

artículo científico publicado en 2005

Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

artículo científico publicado en 2018

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

artículo científico publicado en 2010

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

artículo científico publicado en 2017

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer

artículo científico publicado en 2013

Contributors

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

artículo científico publicado en 2018

EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.

artículo científico publicado en 2018

Erratum: Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia

article

Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia

artículo científico publicado en 2015

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

artículo científico publicado en 2008

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

artículo científico publicado en 2015

Gefitinib induces myeloid differentiation of acute myeloid leukemia

artículo científico publicado en 2005

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

artículo científico publicado en 2006

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

scientific article published on 25 July 2018

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

artículo científico publicado en 2016

Genomic approaches in acute leukemia

artículo científico publicado en 2006

High-throughput gene expression profiling of memory differentiation in primary human T cells

artículo científico publicado en 2008

High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma

artículo científico publicado en 2013

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia

artículo científico publicado en 2017

Identification of AML1-ETO modulators by chemical genomics

artículo científico publicado en 2009

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

artículo científico publicado en 2017

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

scientific article published on 13 June 2013

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

artículo científico publicado en 2015

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia

Leukemia-specific delivery of mutant NOTCH1 targeted therapy.

artículo científico publicado en 2017

Literature Lab: a method of automated literature interrogation to infer biology from microarray analysis

artículo científico publicado en 2007

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis

artículo científico publicado en 2014

MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells

artículo científico publicado en 2013

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

artículo científico publicado en 2014

Mutational heterogeneity in cancer and the search for new cancer-associated genes

artículo científico publicado en 2013

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

artículo científico publicado en 2021

New Approaches to Target T-ALL.

artículo científico publicado en 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group

artículo científico publicado en 2009

Proteomic and genetic approaches identify Syk as an AML target

artículo científico publicado en 2009

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

scientific article published on 18 September 2020

SYK is a critical regulator of FLT3 in acute myeloid leukemia

artículo científico publicado en 2014

Scratching the Surface of Immunotherapeutic Targets in Neuroblastoma

artículo científico publicado en 2017

Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation

artículo científico publicado en 2013

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

artículo científico publicado en 2020

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia

artículo científico publicado en 2016

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

artículo científico publicado en 2017

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer

artículo científico publicado en 2018

Targeted therapy for fusion-driven high-risk acute leukemia

scholarly article by Yana Pikman & Kimberly Stegmaier published 20 September 2018 in Blood

Targeting Csnk1a1 in leukemia

artículo científico publicado en 2014

Targeting MTHFD2 in acute myeloid leukemia

scientific article published on 20 June 2016

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

artículo científico publicado en 2013

Targeting NOTCH1 in hematopoietic malignancy

artículo científico

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

artículo científico publicado en 2016

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

artículo científico publicado en 2017

The genomic landscape of juvenile myelomonocytic leukemia

artículo científico publicado en 2015

The genomic landscape of pediatric Ewing sarcoma

artículo científico publicado en 2014

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia

artículo científico publicado en 2012

Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells

artículo científico publicado en 2019

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

artículo científico publicado en 2014

VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system

artículo científico publicado en 2022

Lista de obras de Kimberly Stegmaier

A first-generation pediatric cancer dependency map

A method for high-throughput gene expression signature analysis

A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regu

Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer

Contributors

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.

Erratum: Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia

Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Gefitinib induces myeloid differentiation of acute myeloid leukemia

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Genomic approaches in acute leukemia

High-throughput gene expression profiling of memory differentiation in primary human T cells

High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia

Identification of AML1-ETO modulators by chemical genomics

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia

Leukemia-specific delivery of mutant NOTCH1 targeted therapy.

Literature Lab: a method of automated literature interrogation to infer biology from microarray analysis

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis

MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

New Approaches to Target T-ALL.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group

Proteomic and genetic approaches identify Syk as an AML target

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

SYK is a critical regulator of FLT3 in acute myeloid leukemia

Scratching the Surface of Immunotherapeutic Targets in Neuroblastoma

Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer

Targeted therapy for fusion-driven high-risk acute leukemia

Targeting Csnk1a1 in leukemia

Targeting MTHFD2 in acute myeloid leukemia

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

Targeting NOTCH1 in hematopoietic malignancy

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

The genomic landscape of juvenile myelomonocytic leukemia

The genomic landscape of pediatric Ewing sarcoma

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia

Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system